A CD30-positive T cell line established from an aggressive anaplastic large cell lymphoma, originally diagnosed as Hodgkin's disease

Annarosa Del Mistro, Anna Leszl, Roberta Bertorelle, Maria Luisa Calabro, Marina Panozzo, Chiara Menin, Emma D'Andrea, Luigi Chieco-Bianchi

Research output: Contribution to journalArticlepeer-review

Abstract

Ten months following the diagnosis of Hodgkin's disease (HD), a 46-year-old woman presented cutaneous and leukemic involvement by CD30+ anaplastic large cells, from which a continuously growing, exogenous growth factor-independent T cell line was established. The cultured cells are phenotypically and genotypically T cell in type, negative for EBV, HTLV-I and HTLV-II viral sequences, and release soluble CD30 into the supernatant. Karyotype analysis disclosed several chromosomal abnormalities, but none on chromosome 5q. The involvement of the short arm of chromosome 17 prompted us to investigate the TP53 gene by means of the polymerase chain reaction single-strand conformation polymorphism (PCR-SSCP) analysis, but no alterations were found in exons 5-8.

Original languageEnglish
Pages (from-to)1214-1219
Number of pages6
JournalLeukemia
Volume8
Issue number7
Publication statusPublished - Jul 1994

ASJC Scopus subject areas

  • Hematology
  • Cancer Research

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