A cell cycle study of the effects of Con A on synchronized mouse embryo fibroblasts: Arrest and dissociation between uptake of thymidine and DNA synthesis

L. Mallucci, M. Dunn, V. Wells, D. Delia

Research output: Contribution to journalArticle

Abstract

We have examined the effects of 50 μg ml-1 of Con A added to synchronized mouse embryo fibroblasts at different times during the cell cycle. We found that Con A caused arrest of growth not solely by preventing G1-G0 cells from entering the S-phase but also by exerting a G2 block. We also found that Con A, which prevented commencement of S-phase, did not arrest cells already in S from reaching the G2 stage but inhibited the S-phase associated process of thymidine uptake. The inhibition was greater when the Con A receptors were extensively clustered.

Original languageEnglish
Pages (from-to)353-363
Number of pages11
JournalJournal of Cell Science
VolumeVOL.46
Publication statusPublished - 1980

ASJC Scopus subject areas

  • Cell Biology

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