A cell division-active protein from E. coli

Alfredo Caprioli, Giantranco Donelli, Vincenzo Falbo, Roberta Possenti, L. Giorgio Roda, Gianna Roscetti, Franco M. Ruggeri

Research output: Contribution to journalArticlepeer-review

Abstract

A purification procedure for a protein obtained from an pathogenic strain of E. coli is described. The protein - called CNF - is active in inhibiting the duplication of cultured mammalian cells. Since nuclei division is apparently normal, treatment of cultured cells with CNF leads to the formation of gigantic, polynucleated cells. The purified protein is chromatographically and electrophoretically homogeneous. A partial characterization of CNF protein is also given.

Original languageEnglish
Pages (from-to)587-593
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume118
Issue number2
DOIs
Publication statusPublished - Jan 30 1984

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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