Abstract
In this study, we introduce a centenarian-only approach to the assessment of gene-gene interaction that contributes to human longevity. This approach corresponds to the non-traditional case-only method in the genetic study of gene and disease associations. We first describe how the method can be implemented to screen for gene-gene interaction in human longevity. Then we apply the method to centenarian data collected from an Italian centenarian study in order to detect the interactions between the REN gene and the mitochondrial haplotypes. A significant interaction between REN gene allele 10 and the mitochondrial H haplotype, which may favour longevity, was found. Important features of the application in human longevity studies are highlighted and discussed. Since centenarians constitute a special population representing successful ageing, the centenarian-only approach will be an important tool in the search for major genes that contribute to human longevity.
| Original language | English |
|---|---|
| Pages (from-to) | 119-124 |
| Number of pages | 6 |
| Journal | European Journal of Human Genetics |
| Volume | 10 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2002 |
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Keywords
- Centenarian-only approach
- Gene-gene interaction
- Longevity
ASJC Scopus subject areas
- Genetics(clinical)
Cite this
A centenarian-only approach for assessing gene - Gene interaction in human longevity. / Tan, Qihua; De Benedictis, Giovanna; Ukraintseva, Svetlana V.; Franceschi, Claudio; Vaupel, James W.; Yashin, Anatoli I.
In: European Journal of Human Genetics, Vol. 10, No. 2, 2002, p. 119-124.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A centenarian-only approach for assessing gene - Gene interaction in human longevity
AU - Tan, Qihua
AU - De Benedictis, Giovanna
AU - Ukraintseva, Svetlana V.
AU - Franceschi, Claudio
AU - Vaupel, James W.
AU - Yashin, Anatoli I.
PY - 2002
Y1 - 2002
N2 - In this study, we introduce a centenarian-only approach to the assessment of gene-gene interaction that contributes to human longevity. This approach corresponds to the non-traditional case-only method in the genetic study of gene and disease associations. We first describe how the method can be implemented to screen for gene-gene interaction in human longevity. Then we apply the method to centenarian data collected from an Italian centenarian study in order to detect the interactions between the REN gene and the mitochondrial haplotypes. A significant interaction between REN gene allele 10 and the mitochondrial H haplotype, which may favour longevity, was found. Important features of the application in human longevity studies are highlighted and discussed. Since centenarians constitute a special population representing successful ageing, the centenarian-only approach will be an important tool in the search for major genes that contribute to human longevity.
AB - In this study, we introduce a centenarian-only approach to the assessment of gene-gene interaction that contributes to human longevity. This approach corresponds to the non-traditional case-only method in the genetic study of gene and disease associations. We first describe how the method can be implemented to screen for gene-gene interaction in human longevity. Then we apply the method to centenarian data collected from an Italian centenarian study in order to detect the interactions between the REN gene and the mitochondrial haplotypes. A significant interaction between REN gene allele 10 and the mitochondrial H haplotype, which may favour longevity, was found. Important features of the application in human longevity studies are highlighted and discussed. Since centenarians constitute a special population representing successful ageing, the centenarian-only approach will be an important tool in the search for major genes that contribute to human longevity.
KW - Centenarian-only approach
KW - Gene-gene interaction
KW - Longevity
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UR - http://www.scopus.com/inward/citedby.url?scp=0036229132&partnerID=8YFLogxK
U2 - 10.1038/sj/ejhg/5200770
DO - 10.1038/sj/ejhg/5200770
M3 - Article
C2 - 11938442
VL - 10
SP - 119
EP - 124
JO - European Journal of Human Genetics
JF - European Journal of Human Genetics
SN - 1018-4813
IS - 2
ER -