TY - JOUR
T1 - A challenging diagnosis of reversible “vascular” dementia
T2 - Cerebral amyloid angiopathy-related inflammation
AU - Poli, L.
AU - De Giuli, V.
AU - Piazza, F.
AU - Volonghi, I.
AU - Bigliardi, G.
AU - Vallone, S.
AU - Nichelli, P. F.
AU - Gasparotti, R.
AU - Zini, A.
AU - Padovani, A.
AU - Pezzini, A.
PY - 2020/1/15
Y1 - 2020/1/15
N2 - Cerebral amyloid angiopathy-related inflammation (CAA-ri) is a rare and treatable variant of CAA likely due to an autoimmune response directed toward beta-amyloid deposits. Cognitive and behavioral manifestations are the most common symptoms, followed by focal neurological signs, headache and seizures, associated with characteristics neuroradiological features on brain magnetic resonance imaging (MRI). We describe the clinical course, radiological features and therapeutic approach of two patients with probable CAA-ri with the aim of emphasizing the importance of an early diagnosis of this potentially reversible disease in different neurological settings, such as memory clinics and stroke units.
AB - Cerebral amyloid angiopathy-related inflammation (CAA-ri) is a rare and treatable variant of CAA likely due to an autoimmune response directed toward beta-amyloid deposits. Cognitive and behavioral manifestations are the most common symptoms, followed by focal neurological signs, headache and seizures, associated with characteristics neuroradiological features on brain magnetic resonance imaging (MRI). We describe the clinical course, radiological features and therapeutic approach of two patients with probable CAA-ri with the aim of emphasizing the importance of an early diagnosis of this potentially reversible disease in different neurological settings, such as memory clinics and stroke units.
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U2 - 10.1016/j.jneuroim.2019.577109
DO - 10.1016/j.jneuroim.2019.577109
M3 - Article
C2 - 31715460
AN - SCOPUS:85074765708
VL - 338
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
SN - 0165-5728
M1 - 577109
ER -