A chart of failure risk for noninvasive ventilation in patients with COPD exacerbation

M. Confalonieri, G. Garuti, M. S. Cattaruzza, J. F. Osborn, M. Antonelli, G. Conti, M. Kodric, O. Resta, S. Marchese, C. Gregoretti, A. Rossi, A. Bellone, R. Della Porta, A. LoCoco, M. Demsar, G. Gadaleta, M. Moretti, P. Parigi, G. Pinelli, M. PiattellaA. Potena, F. Turati, A. Vianello, M. Vitacca

Research output: Contribution to journalArticlepeer-review


Knowing the likelihood of failure of noninvasive positive pressure ventilation (NPPV) in patients with exacerbation of chronic obstructive pulmonary disease (COPD) could indicate the best choice between NPPV and endotracheal intubation instituted earlier. For this purpose, two risk charts were designed (at admission and after 2 h of NPPV) that included all relevant measurable clinical prognostic indicators derived from a population representing the patients seen routinely in clinical practice. Risk stratification of NPPV failure was assessed in 1,033 consecutive patients admitted to experienced hospital units, including two intensive care units, six respiratory intermediate care units, and five general wards. NPPV was successful in 797 patients. Patients with a Glasgow Coma Score -1 and pH at admission 70%. A pH 90%). The risk charts were validated on an independent group of 145 consecutive COPD patients treated with NPPV due to an acute ventilatory failure episode. To identify patients with a probability of failure >50%, the sensitivity and specificity were 33% and 96.7% on admission and 52.9% and 94.1% after 2 h of NPPV, respectively. The prediction chart, based on data from the current study, can function as a simple tool to predict the risk of failure of noninvasive positive pressure ventilation and thus improve clinical management of patients tailoring medical intervention.

Original languageEnglish
Pages (from-to)348-355
Number of pages8
JournalEuropean Respiratory Journal
Issue number2
Publication statusPublished - Feb 2005


  • Chronic obstructive pulmonary disease
  • Endotracheal intubation
  • Noninvasive ventilation
  • Respiratory failure

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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