A checklist for critical appraisal of studies of biological variation

William A. Bartlett, Federica Braga, Anna Carobene, Abdurrahman Coşkun, Richard Prusa, Pilar Fernandez-Calle, Thomas Røraas, Neils Jonker, Sverre Sandberg

Research output: Contribution to journalArticlepeer-review


Data on biological variation are used for many purposes in laboratory medicine but concern exists over the validity of the data reported in some studies. A critical appraisal checklist has been produced by a working group established by the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) to enable standardised assessment of existing and future publications of biological variation data. The checklist identifies key elements to be reported in studies to enable safe accurate and effective transport of biological variation data sets across healthcare systems. The checklist is mapped to the domains of a minimum data set required to enable this process.

Original languageEnglish
Pages (from-to)879-885
Number of pages7
JournalClinical Chemistry and Laboratory Medicine
Issue number6
Publication statusPublished - May 1 2015


  • biological variation
  • checklist
  • critical appraisal
  • reference values

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical


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