Abstract
Human immunodeficiency virus (HIV) expression is boosted after T lymphocyte stimulation. It is not known, however, in which phase(s) of the cell cycle HIV is maximally expressed. We demonstrate here that cell activation induces limited HIV expression and that progression to cell proliferation is required for optimal HIV replication. We also show that the G1/S cell cycle transition is a critical checkpoint in this process and that limiting progression at this step with antiproliferative drugs suppresses HIV replication. These results identify a specific phase of the cell cycle progression that is critical for HIV expression and suggest a new discrete target for anti-HIV treatment.
| Original language | English |
|---|---|
| Pages (from-to) | 1409-1415 |
| Number of pages | 7 |
| Journal | Journal of Infectious Diseases |
| Volume | 196 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - Nov 1 2007 |
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ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
- Immunology
Cite this
A checkpoint in the cell cycle progression as a therapeutic target to inhibit HIV replication. / Foli, Andrea; Maiocchi, Maria Angela; Lisziewicz, Julianna; Lori, Franco.
In: Journal of Infectious Diseases, Vol. 196, No. 9, 01.11.2007, p. 1409-1415.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A checkpoint in the cell cycle progression as a therapeutic target to inhibit HIV replication
AU - Foli, Andrea
AU - Maiocchi, Maria Angela
AU - Lisziewicz, Julianna
AU - Lori, Franco
PY - 2007/11/1
Y1 - 2007/11/1
N2 - Human immunodeficiency virus (HIV) expression is boosted after T lymphocyte stimulation. It is not known, however, in which phase(s) of the cell cycle HIV is maximally expressed. We demonstrate here that cell activation induces limited HIV expression and that progression to cell proliferation is required for optimal HIV replication. We also show that the G1/S cell cycle transition is a critical checkpoint in this process and that limiting progression at this step with antiproliferative drugs suppresses HIV replication. These results identify a specific phase of the cell cycle progression that is critical for HIV expression and suggest a new discrete target for anti-HIV treatment.
AB - Human immunodeficiency virus (HIV) expression is boosted after T lymphocyte stimulation. It is not known, however, in which phase(s) of the cell cycle HIV is maximally expressed. We demonstrate here that cell activation induces limited HIV expression and that progression to cell proliferation is required for optimal HIV replication. We also show that the G1/S cell cycle transition is a critical checkpoint in this process and that limiting progression at this step with antiproliferative drugs suppresses HIV replication. These results identify a specific phase of the cell cycle progression that is critical for HIV expression and suggest a new discrete target for anti-HIV treatment.
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UR - http://www.scopus.com/inward/citedby.url?scp=38449104765&partnerID=8YFLogxK
U2 - 10.1086/521832
DO - 10.1086/521832
M3 - Article
VL - 196
SP - 1409
EP - 1415
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 9
ER -