A checkpoint in the cell cycle progression as a therapeutic target to inhibit HIV replication

Andrea Foli, Maria Angela Maiocchi, Julianna Lisziewicz, Franco Lori

Research output: Contribution to journalArticlepeer-review

Abstract

Human immunodeficiency virus (HIV) expression is boosted after T lymphocyte stimulation. It is not known, however, in which phase(s) of the cell cycle HIV is maximally expressed. We demonstrate here that cell activation induces limited HIV expression and that progression to cell proliferation is required for optimal HIV replication. We also show that the G1/S cell cycle transition is a critical checkpoint in this process and that limiting progression at this step with antiproliferative drugs suppresses HIV replication. These results identify a specific phase of the cell cycle progression that is critical for HIV expression and suggest a new discrete target for anti-HIV treatment.

Original languageEnglish
Pages (from-to)1409-1415
Number of pages7
JournalJournal of Infectious Diseases
Volume196
Issue number9
DOIs
Publication statusPublished - Nov 1 2007

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

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