A chimpanzee-derived chromosome-specific alpha satellite DNA sequence conserved between chimpanzee and human

Antonio Baldini, Dorothy A. Miller, Orlando J. Miller, Oliver A. Ryder, Arthur R. Mitchell

Research output: Contribution to journalArticlepeer-review

Abstract

We describe a cloned 2.7 kb alpha satellite sequence, Pan-3, from the pygmy chimpanzee (Pan paniscus) that specifically hybridizes in situ to chromosome 19 in the pygmy chimpanzee and to the homeologous human chromosome, no. 17. Using high stringency conditions of hybridization on Southern blots, this sequence hybridized to DNA from both species of chimpanzee (P. paniscus and P. troglodytes) and from human but not to DNA from gorilla (Gorilla gorilla) or orangutan (Pongo pygmaeus). Partial sequence analysis showed that Pan-3 and a previously described human chromosome 17-specific clone have up to 91% sequence identity. To our knowledge this is the highest sequence similarity reported between alphoid subsets from human and any other primate.

Original languageEnglish
Pages (from-to)156-161
Number of pages6
JournalChromosoma
Volume100
Issue number3
DOIs
Publication statusPublished - Mar 1991

ASJC Scopus subject areas

  • Genetics

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