A class of non-selective cation channels in human fibroblasts

Luis J V Galietta, Teresa Mastrocola, Mario Nobile

Research output: Contribution to journalArticlepeer-review


Non-selective cation channels were detected in membrane patches of cultured human fibroblasts. The channels had a unitary conductance which ranged from 14 to 25 pS in symmetrical 130 mM NACl and were permeable to both sodium and potassium ions. Open channel probability was dependent either on the membrane potential and the Ca2+ concentration on the intracellular side of the membrane. High Ca2+ concentrations in the millimolar range were needed to keep the channel active.

Original languageEnglish
Pages (from-to)43-46
Number of pages4
JournalFEBS Letters
Issue number1-2
Publication statusPublished - Aug 14 1989


  • (Human fibroblast)
  • Cation channel
  • Patch-clamp technique

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology
  • Cell Biology
  • Genetics
  • Structural Biology


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