A class of non-selective cation channels in human fibroblasts

Luis J V Galietta, Teresa Mastrocola, Mario Nobile

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Non-selective cation channels were detected in membrane patches of cultured human fibroblasts. The channels had a unitary conductance which ranged from 14 to 25 pS in symmetrical 130 mM NACl and were permeable to both sodium and potassium ions. Open channel probability was dependent either on the membrane potential and the Ca2+ concentration on the intracellular side of the membrane. High Ca2+ concentrations in the millimolar range were needed to keep the channel active.

Original languageEnglish
Pages (from-to)43-46
Number of pages4
JournalFEBS Letters
Volume253
Issue number1-2
DOIs
Publication statusPublished - Aug 14 1989

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Intracellular Membranes
Fibroblasts
Membrane Potentials
Cations
Potassium
Sodium
Ions
Membranes

Keywords

  • (Human fibroblast)
  • Cation channel
  • Patch-clamp technique

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology
  • Cell Biology
  • Genetics
  • Structural Biology

Cite this

A class of non-selective cation channels in human fibroblasts. / Galietta, Luis J V; Mastrocola, Teresa; Nobile, Mario.

In: FEBS Letters, Vol. 253, No. 1-2, 14.08.1989, p. 43-46.

Research output: Contribution to journalArticle

Galietta, Luis J V ; Mastrocola, Teresa ; Nobile, Mario. / A class of non-selective cation channels in human fibroblasts. In: FEBS Letters. 1989 ; Vol. 253, No. 1-2. pp. 43-46.
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