Abstract
Piperacillin, unlike other antibiotics, rarely causes immediate allergic reactions. Only two cases related to occupational exposure are reported in the literature. Objectives: Adoption of new methods for diagnosis of occupational allergy to drugs. An atopic nurse, aged 30 years, was referred to our hospital for an allergic work-related reaction to piperacillin. The patient had suffered two successive episodes with immediate cutaneous reaction, angioedema and dyspnoea after preparing piperacillin. Almost four years previously she had suffered from similar symptoms after taking amoxicillin. She was submitted to a clinical examination and a routine allergic test, performing also specific IgE (Phadia Pharmacia ImmunoCap) and BAT (Basophil Activation Test) for Beta-lactam antibiotics. A positive response to piperacillin was observed in our case using BAT a new non-invasive and safe method, that proved useful for diagnosis of allergy. Moreover, we observed a change from an allergic reaction for therapeutic use of amoxicillin to a work-related adverse reaction to another beta-lactam, piperacillin. In previous clinical cases cutaneous and specific challenge tests were performed for diagnosis. At present, availability of an in vitro test, such as BAT may provide new diagnostic opportunities, and a useful tool for studying clinical cases other than, in perspective, monitoring exposed workers. Preventive measures were taken in the workplace to lower the risk of sensitization and allergic response. The nurse was transferred to a well controlled job.
| Original language | Italian |
|---|---|
| Pages (from-to) | 434-439 |
| Number of pages | 6 |
| Journal | Medicina del Lavoro |
| Volume | 104 |
| Issue number | 6 |
| Publication status | Published - 2013 |
Fingerprint
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
Cite this
Utilizzo del test di attivazione dei basofili (BAT) per la diagnosi di reazione allergica a piperacillina in ambito professionale : descrizione di un caso clinico. / Marraccini, P.; Digiesi, G.; Pignatti, Patrizia; Bordini, L.; Previdi, M.
In: Medicina del Lavoro, Vol. 104, No. 6, 2013, p. 434-439.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Utilizzo del test di attivazione dei basofili (BAT) per la diagnosi di reazione allergica a piperacillina in ambito professionale
T2 - descrizione di un caso clinico.
AU - Marraccini, P.
AU - Digiesi, G.
AU - Pignatti, Patrizia
AU - Bordini, L.
AU - Previdi, M.
PY - 2013
Y1 - 2013
N2 - Piperacillin, unlike other antibiotics, rarely causes immediate allergic reactions. Only two cases related to occupational exposure are reported in the literature. Objectives: Adoption of new methods for diagnosis of occupational allergy to drugs. An atopic nurse, aged 30 years, was referred to our hospital for an allergic work-related reaction to piperacillin. The patient had suffered two successive episodes with immediate cutaneous reaction, angioedema and dyspnoea after preparing piperacillin. Almost four years previously she had suffered from similar symptoms after taking amoxicillin. She was submitted to a clinical examination and a routine allergic test, performing also specific IgE (Phadia Pharmacia ImmunoCap) and BAT (Basophil Activation Test) for Beta-lactam antibiotics. A positive response to piperacillin was observed in our case using BAT a new non-invasive and safe method, that proved useful for diagnosis of allergy. Moreover, we observed a change from an allergic reaction for therapeutic use of amoxicillin to a work-related adverse reaction to another beta-lactam, piperacillin. In previous clinical cases cutaneous and specific challenge tests were performed for diagnosis. At present, availability of an in vitro test, such as BAT may provide new diagnostic opportunities, and a useful tool for studying clinical cases other than, in perspective, monitoring exposed workers. Preventive measures were taken in the workplace to lower the risk of sensitization and allergic response. The nurse was transferred to a well controlled job.
AB - Piperacillin, unlike other antibiotics, rarely causes immediate allergic reactions. Only two cases related to occupational exposure are reported in the literature. Objectives: Adoption of new methods for diagnosis of occupational allergy to drugs. An atopic nurse, aged 30 years, was referred to our hospital for an allergic work-related reaction to piperacillin. The patient had suffered two successive episodes with immediate cutaneous reaction, angioedema and dyspnoea after preparing piperacillin. Almost four years previously she had suffered from similar symptoms after taking amoxicillin. She was submitted to a clinical examination and a routine allergic test, performing also specific IgE (Phadia Pharmacia ImmunoCap) and BAT (Basophil Activation Test) for Beta-lactam antibiotics. A positive response to piperacillin was observed in our case using BAT a new non-invasive and safe method, that proved useful for diagnosis of allergy. Moreover, we observed a change from an allergic reaction for therapeutic use of amoxicillin to a work-related adverse reaction to another beta-lactam, piperacillin. In previous clinical cases cutaneous and specific challenge tests were performed for diagnosis. At present, availability of an in vitro test, such as BAT may provide new diagnostic opportunities, and a useful tool for studying clinical cases other than, in perspective, monitoring exposed workers. Preventive measures were taken in the workplace to lower the risk of sensitization and allergic response. The nurse was transferred to a well controlled job.
UR - http://www.scopus.com/inward/record.url?scp=84899966625&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84899966625&partnerID=8YFLogxK
M3 - Articolo
C2 - 24640830
AN - SCOPUS:84899966625
VL - 104
SP - 434
EP - 439
JO - Medicina del Lavoro
JF - Medicina del Lavoro
SN - 0025-7818
IS - 6
ER -