A clinical, electrophysiological, morphological and immunological study of chronic sensory neuropathy with ataxia and paraesthesia

A. Mamoli, R. Nemni, M. Camerlingo, A. Quattrini, L. Casto, I. Lorenzetti, N. Canal

Research output: Contribution to journalArticlepeer-review

Abstract

We have observed 9 patients (8 men and 1 woman), 58 to 77 years of age with neuropathy with only sensory symptoms and insidious onset. Five of them (4 men and 1 woman) aged 65 to 77 years, had normal serum electrophoreticprofiles, while the others (all men), 58 to 74 years, had IgM monoclonal gammopathy of undetermined significance (MGUS). Clinical data were consistent with a sensory neuropathy affecting predominantly the kinesthetic sense (position and vibration sensation). The electrophysiological data indicated predominant sensory axonal neuropathy. Morphological data confirmed the primary axonal damage. Western immunoblot showed that the IgG from a patient without MGUS reacted with a 55 kD protein of dorsal root ganglion homogenate. Three of four patients with IgM MGUS were serum reactive against chondroitin sulfate C (ChS-C) in double immunodiffusion. After absorption with ChS-C the monoclonal peak completely disappeared from two patients and was decreased in the third patient. Our data indicate that immunological abnormalities are part of the pathogenesis for a subgroup of chronic neuropathy with only sensory symptoms.

Original languageEnglish
Pages (from-to)110-115
Number of pages6
JournalActa Neurologica Scandinavica
Volume85
Issue number2
Publication statusPublished - 1992

Keywords

  • autoimmunity
  • chondroitin sulfate C
  • monoclonal gammopathy
  • sensory neuropathy

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Fingerprint Dive into the research topics of 'A clinical, electrophysiological, morphological and immunological study of chronic sensory neuropathy with ataxia and paraesthesia'. Together they form a unique fingerprint.

Cite this