A clinical overview of bone marrow edema

Maria Manara, M. Varenna

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Bone marrow edema (BME) is a descriptive term which identifies a specific magnetic resonance imaging (MRI) pattern that can be observed in a number of clinical entities, which are often characterized by pain as their main symptom, but show significant differences in terms of histopathological findings, causal mechanisms and prognosis. Bone marrow lesions in the subchondral bone of subjects with knee osteoarthritis (OA) seem to be associated with pain and progression of cartilage damage over time. Some histopathological studies of advanced OA have shown a prevalent fibrosis and bone marrow necrosis. BME of the subchondral bone in rheumatoid arthritis is associated with an infiltrate of inflammatory cells and osteoclasts and has a predictive value of further development of erosions. In spondyloarthritis, BME of the sacroiliac joints identifies an active sacroiliitis and is associated with histological inflammation and radiographic progression, whereas the relationship between BME lesions of the spine and syndesmophyte development is still controversial. BME syndromes (BMES), such as transient osteoporosis of the hip, regional migratory osteoporosis, and transient post-traumatic BMES, are characterized by a BME pattern on MRI and a self-limiting course. The potential evolution of BMES toward osteonecrosis is still controversial.

Original languageEnglish
Pages (from-to)184-196
Number of pages13
JournalReumatismo
Volume66
Issue number2
DOIs
Publication statusPublished - 2014

Fingerprint

Edema
Bone Marrow
Osteonecrosis
Osteoporosis
Magnetic Resonance Imaging
Sacroiliitis
Sacroiliac Joint
Bone and Bones
Pain
Knee Osteoarthritis
Osteoclasts
Osteoarthritis
Cartilage
Hip
Rheumatoid Arthritis
Spine
Fibrosis
Inflammation

Keywords

  • Bone marrow edema
  • Magnetic resonance imaging
  • Osteoarthritis

ASJC Scopus subject areas

  • Rheumatology

Cite this

A clinical overview of bone marrow edema. / Manara, Maria; Varenna, M.

In: Reumatismo, Vol. 66, No. 2, 2014, p. 184-196.

Research output: Contribution to journalArticle

Manara, Maria ; Varenna, M. / A clinical overview of bone marrow edema. In: Reumatismo. 2014 ; Vol. 66, No. 2. pp. 184-196.
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