A clinical prediction model for estimating the risk of developing uveitis in patients with juvenile idiopathic arthritis

Paediatric Rheumatology International Trials Organisation (PRINTO), Joeri W. Van Straalen, Gabriella Giancane, Yasmine Amazrhar, Nikolay Tzaribachev, Calin Lazar, Yosef Uziel, Albena Telcharova-Mihaylovska, Claudio A. Len, Angela Miniaci, Alina L. Boteanu, Giovanni Filocamo, Mariel V. Mastri, Thaschawee Arkachaisri, Maria G. Magnolia, Esther Hoppenreijs, Sytze De Roock, Nico M. Wulffraat, Nicolino Ruperto, Joost F. Swart

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To build a prediction model for uveitis in children with JIA for use in current clinical practice. Methods: Data from the international observational Pharmachild registry were used. Adjusted risk factors as well as predictors for JIA-associated uveitis (JIA-U) were determined using multivariable logistic regression models. The prediction model was selected based on the Akaike information criterion. Bootstrap resampling was used to adjust the final prediction model for optimism. Results: JIA-U occurred in 1102 of 5529 JIA patients (19.9%). The majority of patients that developed JIA-U were female (74.1%), ANA positive (66.0%) and had oligoarthritis (59.9%). JIA-U was rarely seen in patients with systemic arthritis (0.5%) and RF positive polyarthritis (0.2%). Independent risk factors for JIA-U were ANA positivity [odds ratio (OR): 1.88 (95% CI: 1.54, 2.30)] and HLA-B27 positivity [OR: 1.48 (95% CI: 1.12, 1.95)] while older age at JIA onset was an independent protective factor [OR: 0.84 (9%% CI: 0.81, 0.87)]. On multivariable analysis, the combination of age at JIA onset [OR: 0.84 (95% CI: 0.82, 0.86)], JIA category and ANA positivity [OR: 2.02 (95% CI: 1.73, 2.36)] had the highest discriminative power among the prediction models considered (optimism-adjusted area under the receiver operating characteristic curve = 0.75). Conclusion: We developed an easy to read model for individual patients with JIA to inform patients/parents on the probability of developing uveitis.

Original languageEnglish
Pages (from-to)2896-2905
Number of pages10
JournalRheumatology (United Kingdom)
Volume60
Issue number6
DOIs
Publication statusPublished - Jun 1 2021

Keywords

  • confounders
  • JIA
  • prediction model
  • risk factors
  • uveitis

ASJC Scopus subject areas

  • Rheumatology
  • Pharmacology (medical)

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