A clinical study of the pineal gland activity in oncologic patients

P. Lissoni, S. Viviani, E. Bajetta, R. Buzzoni, A. Barreca, R. Mauri, M. Resentini, F. Morabito, D. Esposti, G. Esposti

Research output: Contribution to journalArticlepeer-review


It has been known for many years that the pineal gland is involved in regulating tumor growth. In order to evaluate the functional activity of the pineal gland in neoplastic diseases, melatonin serum levels and its light/dark rhythm have been determined with the RIA method in patients affected by various forms of tumor. Irrespectively of the type of the tumor and of its localization, existence of two subpopulations has been observed within the oncologic patients, the former with normal levels of melatonin, and the latter with high ones. The light/dark rhythm of melatonin was anomalous in some cases. An evident decrease of serum melatonin values was seen after chemotherapy. It might be interesting to establish whether melatonin levels may conditionate the prognosis of patients with cancer.

Original languageEnglish
Pages (from-to)837-842
Number of pages6
Issue number4
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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