A clinicopathologic study of primary hepatic carcinoid tumors

S. Andreola, L. Lombardi, R. A. Audisio, V. Mazzaferro, D. Koukouras, R. Doci, L. Gennari, L. Makowka, T. E. Starzl, D. H. Van Thiel

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Abstract

Six cases of primary hepatic carcinoid tumors were studied with combined immunocytochemical and electron microscopic techniques. Positive tumor immunostaining with PHE5, LK2H10, neuron-specific enolase (NSE), serotonin, gastrin, and insulin antibodies was observed. At the ultrastructural level, cytoplasmic dense granules were seen in all the cases tested. This finding supports a putative origin of these carcinoids found in the liver from a pluripotential stem cell. The clinical course and follow-up of these cases suggests that this unusual hepatic neoplasm has a more favorable prognosis than other forms of hepatic cancer.

Original languageEnglish
Pages (from-to)1211-1218
Number of pages8
JournalCancer
Volume65
Issue number5
Publication statusPublished - 1990

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Carcinoid Tumor
Liver Neoplasms
Insulin Antibodies
Cytoplasmic Granules
Phosphopyruvate Hydratase
Liver
Gastrins
Serotonin
Stem Cells
Electrons
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Andreola, S., Lombardi, L., Audisio, R. A., Mazzaferro, V., Koukouras, D., Doci, R., ... Van Thiel, D. H. (1990). A clinicopathologic study of primary hepatic carcinoid tumors. Cancer, 65(5), 1211-1218.

A clinicopathologic study of primary hepatic carcinoid tumors. / Andreola, S.; Lombardi, L.; Audisio, R. A.; Mazzaferro, V.; Koukouras, D.; Doci, R.; Gennari, L.; Makowka, L.; Starzl, T. E.; Van Thiel, D. H.

In: Cancer, Vol. 65, No. 5, 1990, p. 1211-1218.

Research output: Contribution to journalArticle

Andreola, S, Lombardi, L, Audisio, RA, Mazzaferro, V, Koukouras, D, Doci, R, Gennari, L, Makowka, L, Starzl, TE & Van Thiel, DH 1990, 'A clinicopathologic study of primary hepatic carcinoid tumors', Cancer, vol. 65, no. 5, pp. 1211-1218.
Andreola S, Lombardi L, Audisio RA, Mazzaferro V, Koukouras D, Doci R et al. A clinicopathologic study of primary hepatic carcinoid tumors. Cancer. 1990;65(5):1211-1218.
Andreola, S. ; Lombardi, L. ; Audisio, R. A. ; Mazzaferro, V. ; Koukouras, D. ; Doci, R. ; Gennari, L. ; Makowka, L. ; Starzl, T. E. ; Van Thiel, D. H. / A clinicopathologic study of primary hepatic carcinoid tumors. In: Cancer. 1990 ; Vol. 65, No. 5. pp. 1211-1218.
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