Abstract
Chronic liver disease is not often reported in patients with haemophilia. Although a high incidence of abnormal liver function tests has been reported, the clinical significance of these findings and their relation to chronic liver disease cannot be established without a liver biopsy. The results of this procedure, carried out in 11 patients with severe haemophilia A and B, in whom SGOT had been persistently raised for three years, are reported. Five patients had chronic active hepatitis, four had chronic persistent hepatitis, one had cirrhosis, and one alcoholic hepatitis. No haemorrhagic complication followed the biopsy procedure, which was carried out in patients given prophylactic clotting factor concentrates. These results suggest that duration of abnormal liver function tests is likely to represent liver disease in haemophiliacs, and that biopsy should be considered to establish the diagnosis and plan a suitable therapeutic program.
| Original language | English |
|---|---|
| Pages (from-to) | 779-783 |
| Number of pages | 5 |
| Journal | Journal of Clinical Pathology |
| Volume | 31 |
| Issue number | 8 |
| Publication status | Published - 1978 |
Fingerprint
ASJC Scopus subject areas
- Pathology and Forensic Medicine
Cite this
A clinicopathological study of liver disease in haemophiliacs. / Mannucci, P. M.; Ronchi, G.; Rota, L.; Colombo, M.
In: Journal of Clinical Pathology, Vol. 31, No. 8, 1978, p. 779-783.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A clinicopathological study of liver disease in haemophiliacs
AU - Mannucci, P. M.
AU - Ronchi, G.
AU - Rota, L.
AU - Colombo, M.
PY - 1978
Y1 - 1978
N2 - Chronic liver disease is not often reported in patients with haemophilia. Although a high incidence of abnormal liver function tests has been reported, the clinical significance of these findings and their relation to chronic liver disease cannot be established without a liver biopsy. The results of this procedure, carried out in 11 patients with severe haemophilia A and B, in whom SGOT had been persistently raised for three years, are reported. Five patients had chronic active hepatitis, four had chronic persistent hepatitis, one had cirrhosis, and one alcoholic hepatitis. No haemorrhagic complication followed the biopsy procedure, which was carried out in patients given prophylactic clotting factor concentrates. These results suggest that duration of abnormal liver function tests is likely to represent liver disease in haemophiliacs, and that biopsy should be considered to establish the diagnosis and plan a suitable therapeutic program.
AB - Chronic liver disease is not often reported in patients with haemophilia. Although a high incidence of abnormal liver function tests has been reported, the clinical significance of these findings and their relation to chronic liver disease cannot be established without a liver biopsy. The results of this procedure, carried out in 11 patients with severe haemophilia A and B, in whom SGOT had been persistently raised for three years, are reported. Five patients had chronic active hepatitis, four had chronic persistent hepatitis, one had cirrhosis, and one alcoholic hepatitis. No haemorrhagic complication followed the biopsy procedure, which was carried out in patients given prophylactic clotting factor concentrates. These results suggest that duration of abnormal liver function tests is likely to represent liver disease in haemophiliacs, and that biopsy should be considered to establish the diagnosis and plan a suitable therapeutic program.
UR - http://www.scopus.com/inward/record.url?scp=0018071620&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018071620&partnerID=8YFLogxK
M3 - Article
C2 - 690243
AN - SCOPUS:0018071620
VL - 31
SP - 779
EP - 783
JO - Journal of Clinical Pathology - Clinical Molecular Pathology
JF - Journal of Clinical Pathology - Clinical Molecular Pathology
SN - 0021-9746
IS - 8
ER -