A closer look at nerve growth factor: From biology to clinical trials in ophthalmology

Flavio Mantelli, Marta Sacchetti, Gianluca Scuderi, Alessandro Lambiase

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: Nerve growth factor (NGF) is a pleiotropic neurotrophin that extends its biological activity from the CNS and peripheral nervous system to the immune, endocrine and visual systems. A recombinant human NGF (rhNGF) was developed for systemic administration in diabetic and HIV-related neuropathy but it did not reach the market due to the failure of a Phase III study. More recently, experimental and clinical data showed that NGF eye drop treatment may be effective in several ophthalmic diseases, and clinical trials with a new rhNGF eye drops are currently ongoing.Areas covered: rhNGF produced in Escherichia coli was approved in Europe and in the United States for use in clinical trials in ophthalmic diseases. A Phase I study showed that rhNGF eye drops are safe and well tolerated. rhNGF has recently obtained Orphan Drug Designation for retinitis pigmentosa (RP) and neurotrophic keratopathy and Phase II clinical trials on these conditions are currently ongoing. The authors examine preclinical, pharmacokinetic, safety and efficacy data from the studies using topical ocular NGF.Expert opinion: Results from preclinical, clinical and safety studies have indicated that rhNGF eye drops represent a promising treatment for ophthalmic diseases currently lacking an effective therapy such as neurotrophic keratitis, RP, dry eye and glaucoma.

Original languageEnglish
Pages (from-to)329-341
Number of pages13
JournalExpert Opinion on Orphan Drugs
Volume3
Issue number3
DOIs
Publication statusPublished - Mar 1 2015

Keywords

  • Drug development
  • Nerve growth factor
  • Neurotrophic keratitis
  • Neurotrophin
  • Retinitis pigmentosa

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Health Policy
  • Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

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