TY - JOUR
T1 - A collaborative case-control study of nutrient intake and pancreatic cancer within the search programme
AU - Howe, G. R.
AU - Ghadirian, P.
AU - Bueno De Mesquita, H. B.
AU - Zatonski, W. A.
AU - Baghurst, P. A.
AU - Miller, A. B.
AU - Simard, A.
AU - Baillargeon, J.
AU - De Waard, F.
AU - Przewozniak, K.
AU - McMichael, A. J.
AU - Jain, M.
AU - Hsieh, C. C.
AU - Maisonneuve, P.
AU - Boyle, P.
AU - Walker, A. M.
PY - 1992
Y1 - 1992
N2 - Case-control studies of pancreatic cancer were conducted in 5 populations with moderate to high rates and differing dietary practices, using a common protocol and questionnaire. Comprehensive diet histories were completed for a total of 802 cases and 1669 controls identified in Adelaide (Australia), Montreal and Toronto (Canada), Utrecht (The Netherlands) and Opole (Poland). Positive associations were observed with intake of carbohydrates and cholesterol, and inverse associations with dietary fiber and vitamin C. These relationships were generally consistent among the 5 studies, and showed statistically significant and generally monotonic dose-response relationships. The relative risks for highest vs. lowest quintile of intake were estimated for carbohydrates to be 2.57 (95% confidence interval 1.64-4.03), cholesterol 2.68 (1.72-4.17), dietary fiber 0.45 (0.30-0.63), and vitamin C 0.53 (0.38-0.76). The consistency, strength, and specificity of these associations provides evidence for the hypothesis that some or all of these dietary factors may alter the risk of pancreatic cancer.
AB - Case-control studies of pancreatic cancer were conducted in 5 populations with moderate to high rates and differing dietary practices, using a common protocol and questionnaire. Comprehensive diet histories were completed for a total of 802 cases and 1669 controls identified in Adelaide (Australia), Montreal and Toronto (Canada), Utrecht (The Netherlands) and Opole (Poland). Positive associations were observed with intake of carbohydrates and cholesterol, and inverse associations with dietary fiber and vitamin C. These relationships were generally consistent among the 5 studies, and showed statistically significant and generally monotonic dose-response relationships. The relative risks for highest vs. lowest quintile of intake were estimated for carbohydrates to be 2.57 (95% confidence interval 1.64-4.03), cholesterol 2.68 (1.72-4.17), dietary fiber 0.45 (0.30-0.63), and vitamin C 0.53 (0.38-0.76). The consistency, strength, and specificity of these associations provides evidence for the hypothesis that some or all of these dietary factors may alter the risk of pancreatic cancer.
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U2 - 10.1002/ijc.2910510306
DO - 10.1002/ijc.2910510306
M3 - Article
C2 - 1317361
AN - SCOPUS:0026647091
VL - 51
SP - 365
EP - 372
JO - International Journal of Cancer
JF - International Journal of Cancer
SN - 0020-7136
IS - 3
ER -