A collaborative case-control study of nutrient intake and pancreatic cancer within the search programme

G. R. Howe; P. Ghadirian; H. B. Bueno De Mesquita; W. A. Zatonski; P. A. Baghurst; A. B. Miller; A. Simard; J. Baillargeon; F. De Waard; K. Przewozniak; A. J. McMichael; M. Jain; C. C. Hsieh; P. Maisonneuve; P. Boyle; A. M. Walker

doi:10.1002/ijc.2910510306

A collaborative case-control study of nutrient intake and pancreatic cancer within the search programme

G. R. Howe, P. Ghadirian, H. B. Bueno De Mesquita, W. A. Zatonski, P. A. Baghurst, A. B. Miller, A. Simard, J. Baillargeon, F. De Waard, K. Przewozniak, A. J. McMichael, M. Jain, C. C. Hsieh, P. Maisonneuve, P. Boyle, A. M. Walker

Istituto Europeo di Oncologia

Research output: Contribution to journal › Article › peer-review

Abstract

Case-control studies of pancreatic cancer were conducted in 5 populations with moderate to high rates and differing dietary practices, using a common protocol and questionnaire. Comprehensive diet histories were completed for a total of 802 cases and 1669 controls identified in Adelaide (Australia), Montreal and Toronto (Canada), Utrecht (The Netherlands) and Opole (Poland). Positive associations were observed with intake of carbohydrates and cholesterol, and inverse associations with dietary fiber and vitamin C. These relationships were generally consistent among the 5 studies, and showed statistically significant and generally monotonic dose-response relationships. The relative risks for highest vs. lowest quintile of intake were estimated for carbohydrates to be 2.57 (95% confidence interval 1.64-4.03), cholesterol 2.68 (1.72-4.17), dietary fiber 0.45 (0.30-0.63), and vitamin C 0.53 (0.38-0.76). The consistency, strength, and specificity of these associations provides evidence for the hypothesis that some or all of these dietary factors may alter the risk of pancreatic cancer.

Original language	English
Pages (from-to)	365-372
Number of pages	8
Journal	International Journal of Cancer
Volume	51
Issue number	3
DOIs	https://doi.org/10.1002/ijc.2910510306
Publication status	Published - 1992

ASJC Scopus subject areas

Cancer Research
Oncology

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Howe, G. R., Ghadirian, P., Bueno De Mesquita, H. B., Zatonski, W. A., Baghurst, P. A., Miller, A. B., Simard, A., Baillargeon, J., De Waard, F., Przewozniak, K., McMichael, A. J., Jain, M., Hsieh, C. C., Maisonneuve, P., Boyle, P., & Walker, A. M. (1992). A collaborative case-control study of nutrient intake and pancreatic cancer within the search programme. International Journal of Cancer, 51(3), 365-372. https://doi.org/10.1002/ijc.2910510306

A collaborative case-control study of nutrient intake and pancreatic cancer within the search programme. / Howe, G. R.; Ghadirian, P.; Bueno De Mesquita, H. B.; Zatonski, W. A.; Baghurst, P. A.; Miller, A. B.; Simard, A.; Baillargeon, J.; De Waard, F.; Przewozniak, K.; McMichael, A. J.; Jain, M.; Hsieh, C. C.; Maisonneuve, P.; Boyle, P.; Walker, A. M.

In: International Journal of Cancer, Vol. 51, No. 3, 1992, p. 365-372.

Research output: Contribution to journal › Article › peer-review

Howe, GR, Ghadirian, P, Bueno De Mesquita, HB, Zatonski, WA, Baghurst, PA, Miller, AB, Simard, A, Baillargeon, J, De Waard, F, Przewozniak, K, McMichael, AJ, Jain, M, Hsieh, CC, Maisonneuve, P, Boyle, P & Walker, AM 1992, 'A collaborative case-control study of nutrient intake and pancreatic cancer within the search programme', International Journal of Cancer, vol. 51, no. 3, pp. 365-372. https://doi.org/10.1002/ijc.2910510306

Howe, G. R. ; Ghadirian, P. ; Bueno De Mesquita, H. B. ; Zatonski, W. A. ; Baghurst, P. A. ; Miller, A. B. ; Simard, A. ; Baillargeon, J. ; De Waard, F. ; Przewozniak, K. ; McMichael, A. J. ; Jain, M. ; Hsieh, C. C. ; Maisonneuve, P. ; Boyle, P. ; Walker, A. M. / A collaborative case-control study of nutrient intake and pancreatic cancer within the search programme. In: International Journal of Cancer. 1992 ; Vol. 51, No. 3. pp. 365-372.

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abstract = "Case-control studies of pancreatic cancer were conducted in 5 populations with moderate to high rates and differing dietary practices, using a common protocol and questionnaire. Comprehensive diet histories were completed for a total of 802 cases and 1669 controls identified in Adelaide (Australia), Montreal and Toronto (Canada), Utrecht (The Netherlands) and Opole (Poland). Positive associations were observed with intake of carbohydrates and cholesterol, and inverse associations with dietary fiber and vitamin C. These relationships were generally consistent among the 5 studies, and showed statistically significant and generally monotonic dose-response relationships. The relative risks for highest vs. lowest quintile of intake were estimated for carbohydrates to be 2.57 (95% confidence interval 1.64-4.03), cholesterol 2.68 (1.72-4.17), dietary fiber 0.45 (0.30-0.63), and vitamin C 0.53 (0.38-0.76). The consistency, strength, and specificity of these associations provides evidence for the hypothesis that some or all of these dietary factors may alter the risk of pancreatic cancer.",

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