Abstract
We report a case of pancreatic tumour metastatic to the liver in a patient with insulin-treated diabetes, anaemia, cheilitis, necrolytic migratory erythema, hypokalemia and chronic watery diarrhea, a picture suggesting combined glucagonoma and VIPoma syndromes. Immunocytochemistry of a biopsied hepatic metastatic nodule revealed both glucagon and vasoactive intestinal peptide (VIP) positive cells. Increased plasma glucagon and VIP levels were detected (values of 900 pmol/l and 277 pmol/l respectively). This is the first reported case showing not only immunocytochemical, but also clinical evidence of the combined secretion of these hormones.
Original language | English |
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Pages (from-to) | 2576-2579 |
Number of pages | 4 |
Journal | Cancer |
Volume | 62 |
Issue number | 12 |
Publication status | Published - 1988 |
ASJC Scopus subject areas
- Cancer Research
- Oncology