Abstract
We report a case of pancreatic tumour metastatic to the liver in a patient with insulin-treated diabetes, anaemia, cheilitis, necrolytic migratory erythema, hypokalemia and chronic watery diarrhea, a picture suggesting combined glucagonoma and VIPoma syndromes. Immunocytochemistry of a biopsied hepatic metastatic nodule revealed both glucagon and vasoactive intestinal peptide (VIP) positive cells. Increased plasma glucagon and VIP levels were detected (values of 900 pmol/l and 277 pmol/l respectively). This is the first reported case showing not only immunocytochemical, but also clinical evidence of the combined secretion of these hormones.
| Original language | English |
|---|---|
| Pages (from-to) | 2576-2579 |
| Number of pages | 4 |
| Journal | Cancer |
| Volume | 62 |
| Issue number | 12 |
| Publication status | Published - 1988 |
ASJC Scopus subject areas
- Cancer Research
- Oncology