A combined glucagonoma and VIPoma syndrome: First pathologic and clinical report

P. Cavallo-Perin, M. De Paoli, G. Guiso, A. Sapino, M. Papotti, R. Coda, G. Pagano

Research output: Contribution to journalArticlepeer-review

Abstract

We report a case of pancreatic tumour metastatic to the liver in a patient with insulin-treated diabetes, anaemia, cheilitis, necrolytic migratory erythema, hypokalemia and chronic watery diarrhea, a picture suggesting combined glucagonoma and VIPoma syndromes. Immunocytochemistry of a biopsied hepatic metastatic nodule revealed both glucagon and vasoactive intestinal peptide (VIP) positive cells. Increased plasma glucagon and VIP levels were detected (values of 900 pmol/l and 277 pmol/l respectively). This is the first reported case showing not only immunocytochemical, but also clinical evidence of the combined secretion of these hormones.

Original languageEnglish
Pages (from-to)2576-2579
Number of pages4
JournalCancer
Volume62
Issue number12
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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