Abstract
We report a case of pancreatic tumour metastatic to the liver in a patient with insulin-treated diabetes, anaemia, cheilitis, necrolytic migratory erythema, hypokalemia and chronic watery diarrhea, a picture suggesting combined glucagonoma and VIPoma syndromes. Immunocytochemistry of a biopsied hepatic metastatic nodule revealed both glucagon and vasoactive intestinal peptide (VIP) positive cells. Increased plasma glucagon and VIP levels were detected (values of 900 pmol/l and 277 pmol/l respectively). This is the first reported case showing not only immunocytochemical, but also clinical evidence of the combined secretion of these hormones.
| Original language | English |
|---|---|
| Pages (from-to) | 2576-2579 |
| Number of pages | 4 |
| Journal | Cancer |
| Volume | 62 |
| Issue number | 12 |
| Publication status | Published - 1988 |
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ASJC Scopus subject areas
- Cancer Research
- Oncology
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A combined glucagonoma and VIPoma syndrome : First pathologic and clinical report. / Cavallo-Perin, P.; De Paoli, M.; Guiso, G.; Sapino, A.; Papotti, M.; Coda, R.; Pagano, G.
In: Cancer, Vol. 62, No. 12, 1988, p. 2576-2579.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A combined glucagonoma and VIPoma syndrome
T2 - First pathologic and clinical report
AU - Cavallo-Perin, P.
AU - De Paoli, M.
AU - Guiso, G.
AU - Sapino, A.
AU - Papotti, M.
AU - Coda, R.
AU - Pagano, G.
PY - 1988
Y1 - 1988
N2 - We report a case of pancreatic tumour metastatic to the liver in a patient with insulin-treated diabetes, anaemia, cheilitis, necrolytic migratory erythema, hypokalemia and chronic watery diarrhea, a picture suggesting combined glucagonoma and VIPoma syndromes. Immunocytochemistry of a biopsied hepatic metastatic nodule revealed both glucagon and vasoactive intestinal peptide (VIP) positive cells. Increased plasma glucagon and VIP levels were detected (values of 900 pmol/l and 277 pmol/l respectively). This is the first reported case showing not only immunocytochemical, but also clinical evidence of the combined secretion of these hormones.
AB - We report a case of pancreatic tumour metastatic to the liver in a patient with insulin-treated diabetes, anaemia, cheilitis, necrolytic migratory erythema, hypokalemia and chronic watery diarrhea, a picture suggesting combined glucagonoma and VIPoma syndromes. Immunocytochemistry of a biopsied hepatic metastatic nodule revealed both glucagon and vasoactive intestinal peptide (VIP) positive cells. Increased plasma glucagon and VIP levels were detected (values of 900 pmol/l and 277 pmol/l respectively). This is the first reported case showing not only immunocytochemical, but also clinical evidence of the combined secretion of these hormones.
UR - http://www.scopus.com/inward/record.url?scp=0024209395&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024209395&partnerID=8YFLogxK
M3 - Article
VL - 62
SP - 2576
EP - 2579
JO - Cancer
JF - Cancer
SN - 0008-543X
IS - 12
ER -