A combined glucagonoma and VIPoma syndrome

First pathologic and clinical report

P. Cavallo-Perin, M. De Paoli, G. Guiso, A. Sapino, M. Papotti, R. Coda, G. Pagano

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We report a case of pancreatic tumour metastatic to the liver in a patient with insulin-treated diabetes, anaemia, cheilitis, necrolytic migratory erythema, hypokalemia and chronic watery diarrhea, a picture suggesting combined glucagonoma and VIPoma syndromes. Immunocytochemistry of a biopsied hepatic metastatic nodule revealed both glucagon and vasoactive intestinal peptide (VIP) positive cells. Increased plasma glucagon and VIP levels were detected (values of 900 pmol/l and 277 pmol/l respectively). This is the first reported case showing not only immunocytochemical, but also clinical evidence of the combined secretion of these hormones.

Original languageEnglish
Pages (from-to)2576-2579
Number of pages4
JournalCancer
Volume62
Issue number12
Publication statusPublished - 1988

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Vipoma
Glucagonoma
Vasoactive Intestinal Peptide
Glucagon
Necrolytic Migratory Erythema
Cheilitis
Hypokalemia
Liver
Anemia
Diarrhea
Immunohistochemistry
Hormones
Insulin
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Cavallo-Perin, P., De Paoli, M., Guiso, G., Sapino, A., Papotti, M., Coda, R., & Pagano, G. (1988). A combined glucagonoma and VIPoma syndrome: First pathologic and clinical report. Cancer, 62(12), 2576-2579.

A combined glucagonoma and VIPoma syndrome : First pathologic and clinical report. / Cavallo-Perin, P.; De Paoli, M.; Guiso, G.; Sapino, A.; Papotti, M.; Coda, R.; Pagano, G.

In: Cancer, Vol. 62, No. 12, 1988, p. 2576-2579.

Research output: Contribution to journalArticle

Cavallo-Perin, P, De Paoli, M, Guiso, G, Sapino, A, Papotti, M, Coda, R & Pagano, G 1988, 'A combined glucagonoma and VIPoma syndrome: First pathologic and clinical report', Cancer, vol. 62, no. 12, pp. 2576-2579.
Cavallo-Perin P, De Paoli M, Guiso G, Sapino A, Papotti M, Coda R et al. A combined glucagonoma and VIPoma syndrome: First pathologic and clinical report. Cancer. 1988;62(12):2576-2579.
Cavallo-Perin, P. ; De Paoli, M. ; Guiso, G. ; Sapino, A. ; Papotti, M. ; Coda, R. ; Pagano, G. / A combined glucagonoma and VIPoma syndrome : First pathologic and clinical report. In: Cancer. 1988 ; Vol. 62, No. 12. pp. 2576-2579.
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