A combined intravesical therapy with hyaluronic acid and chondroitin for refractory painful bladder syndrome/interstitial cystitis

M. Cervigni, F. Natale, L. Nasta, A. Padoa, R. L. Voi, D. Porru

Research output: Contribution to journalArticlepeer-review

Abstract

The aims of this study were to evaluate the efficacy and tolerability of intravesical instillations of high-molecular-weight hyaluronic acid (HA) 1.6% and chondroitin sulfate (CS) 2.0% in patients with refractory painful bladder syndrome/interstitial cystitis (PBS/IC) and to observe their impact on Quality of Life. Twenty-three women were enrolled. They received bladder instillations with HA and CS weekly for 20 weeks and then monthly for 3 months. Mean follow-up after completion of therapy was 5 months. We observed a significant improvement in urinary symptoms on voiding diaries and Visual Analogue Scale for frequency (p=0.045), urgency (p=0.005), and pain (p=0.001). The O'Leary-Sant Interstitial Cystitis Symptom Index and Interstitial Cystitis Problem Index resulted in a significant improvement in both scores (p=0.004 and 0.01, respectively). The Pelvic Pain and Urgency/Frequency Symptom Scale only showed significant improvement in the symptom score (p=0.001). This promising experience seems to offer an additional therapeutic option in patients with refractory PBS/IC.

Original languageEnglish
Pages (from-to)943-947
Number of pages5
JournalInternational Urogynecology Journal and Pelvic Floor Dysfunction
Volume19
Issue number7
DOIs
Publication statusPublished - Jun 2008

Keywords

  • Bladder instillation
  • Chondroitin
  • Hyaluronic acid
  • Interstitial cystitis
  • Painful bladder syndrome

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Urology

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