A common genetic variant in FCGR3A-V158F and risk of Kaposi sarcoma herpesvirus infection and classic Kaposi sarcoma

Elizabeth E. Brown, M. Daniele Fallin, James J. Goedert, Renee Chen, Denise Whitby, Charles B. Foster, Carmela Lauria, Anthony J. Alberg, Angelo Messina, Mauizio Montella, Giovanni Rezza, Francesco Vitale, Stephen J. Chanock

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Associations of FCGR3A among men with HIV/acquired immunodeficiency syndrome suggest that host responses affect the pathogenesis of Kaposi sarcoma herpesvirus (KSHV) infection and risk of acquired immunodeficiency syndrome-associated Kaposi sarcoma. Using DNA from two HIV seronegative case-control populations in Italy, we examined whether the functional FCGR3A-V158F variant was associated with risk of KSHV infection or classic Kaposi sarcoma (CKS). In population I, we examined FCGR3A variants and risk of KSHV infection in 34 KSHV latent nuclear antigen (LANA)-seropositive and 120 LANA-seronegative adults from Sardinia (52% male; median age, 45 years; range, 31-60), whereas in population II, we examined risk of CKS from 133 CKS cases and 172 KSHV LANA-seropositive controls from Sicily, Rome, and Naples (70% males; median age, 74 years; range, 29-91). FCGK3A variants were determined by direct sequence analysis of a nested PCR of genomic DNA assay using allele-specific primers. KSHV LANA was determined by immunofluorescence assay. Overall, compared with the 158F allele, 158V was overrepresented among controls from both Mediterranean populations (frequency = 0.52 and 0.51, respectively). After controlling for age, 158V homozygous women were at increased risk of KSHV infection and CKS compared with 158F homozygous women [odds ratio (OR), 8.7; 95% confidence interval (95% CI), 0.8-98 and OR, 3.8; 95% CI, 1.0-14, respectively], whereas homozygous men were at decreased risk (OR, 0.4; 95% CI, 0.1-2.3 and OR, 0.4; 95% CI, 0.2-0.8, respectively). Significant gene-dose effects were observed among men and women at risk for CKS (Ptrend ≤ 0.05). Our findings suggest that gender differences could possibly modify the effect of FCGR3A on risk of KSHV infection and CKS. Additional studies are required to confirm these relationships and determine their etiologic significance.

Original languageEnglish
Pages (from-to)633-637
Number of pages5
JournalCancer Epidemiology Biomarkers and Prevention
Volume14
Issue number3
DOIs
Publication statusPublished - Mar 2005

Fingerprint

Herpesviridae Infections
Kaposi's Sarcoma
Odds Ratio
Herpesviridae
Confidence Intervals
Italy
Population
Acquired Immunodeficiency Syndrome
Alleles
HIV
Sicily
DNA

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

A common genetic variant in FCGR3A-V158F and risk of Kaposi sarcoma herpesvirus infection and classic Kaposi sarcoma. / Brown, Elizabeth E.; Fallin, M. Daniele; Goedert, James J.; Chen, Renee; Whitby, Denise; Foster, Charles B.; Lauria, Carmela; Alberg, Anthony J.; Messina, Angelo; Montella, Mauizio; Rezza, Giovanni; Vitale, Francesco; Chanock, Stephen J.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 14, No. 3, 03.2005, p. 633-637.

Research output: Contribution to journalArticle

Brown, EE, Fallin, MD, Goedert, JJ, Chen, R, Whitby, D, Foster, CB, Lauria, C, Alberg, AJ, Messina, A, Montella, M, Rezza, G, Vitale, F & Chanock, SJ 2005, 'A common genetic variant in FCGR3A-V158F and risk of Kaposi sarcoma herpesvirus infection and classic Kaposi sarcoma', Cancer Epidemiology Biomarkers and Prevention, vol. 14, no. 3, pp. 633-637. https://doi.org/10.1158/1055-9965.EPI-04-0598
Brown, Elizabeth E. ; Fallin, M. Daniele ; Goedert, James J. ; Chen, Renee ; Whitby, Denise ; Foster, Charles B. ; Lauria, Carmela ; Alberg, Anthony J. ; Messina, Angelo ; Montella, Mauizio ; Rezza, Giovanni ; Vitale, Francesco ; Chanock, Stephen J. / A common genetic variant in FCGR3A-V158F and risk of Kaposi sarcoma herpesvirus infection and classic Kaposi sarcoma. In: Cancer Epidemiology Biomarkers and Prevention. 2005 ; Vol. 14, No. 3. pp. 633-637.
@article{193cd0580fdd4645adf5ccd16ede0346,
title = "A common genetic variant in FCGR3A-V158F and risk of Kaposi sarcoma herpesvirus infection and classic Kaposi sarcoma",
abstract = "Associations of FCGR3A among men with HIV/acquired immunodeficiency syndrome suggest that host responses affect the pathogenesis of Kaposi sarcoma herpesvirus (KSHV) infection and risk of acquired immunodeficiency syndrome-associated Kaposi sarcoma. Using DNA from two HIV seronegative case-control populations in Italy, we examined whether the functional FCGR3A-V158F variant was associated with risk of KSHV infection or classic Kaposi sarcoma (CKS). In population I, we examined FCGR3A variants and risk of KSHV infection in 34 KSHV latent nuclear antigen (LANA)-seropositive and 120 LANA-seronegative adults from Sardinia (52{\%} male; median age, 45 years; range, 31-60), whereas in population II, we examined risk of CKS from 133 CKS cases and 172 KSHV LANA-seropositive controls from Sicily, Rome, and Naples (70{\%} males; median age, 74 years; range, 29-91). FCGK3A variants were determined by direct sequence analysis of a nested PCR of genomic DNA assay using allele-specific primers. KSHV LANA was determined by immunofluorescence assay. Overall, compared with the 158F allele, 158V was overrepresented among controls from both Mediterranean populations (frequency = 0.52 and 0.51, respectively). After controlling for age, 158V homozygous women were at increased risk of KSHV infection and CKS compared with 158F homozygous women [odds ratio (OR), 8.7; 95{\%} confidence interval (95{\%} CI), 0.8-98 and OR, 3.8; 95{\%} CI, 1.0-14, respectively], whereas homozygous men were at decreased risk (OR, 0.4; 95{\%} CI, 0.1-2.3 and OR, 0.4; 95{\%} CI, 0.2-0.8, respectively). Significant gene-dose effects were observed among men and women at risk for CKS (Ptrend ≤ 0.05). Our findings suggest that gender differences could possibly modify the effect of FCGR3A on risk of KSHV infection and CKS. Additional studies are required to confirm these relationships and determine their etiologic significance.",
author = "Brown, {Elizabeth E.} and Fallin, {M. Daniele} and Goedert, {James J.} and Renee Chen and Denise Whitby and Foster, {Charles B.} and Carmela Lauria and Alberg, {Anthony J.} and Angelo Messina and Mauizio Montella and Giovanni Rezza and Francesco Vitale and Chanock, {Stephen J.}",
year = "2005",
month = "3",
doi = "10.1158/1055-9965.EPI-04-0598",
language = "English",
volume = "14",
pages = "633--637",
journal = "Cancer Epidemiology Biomarkers and Prevention",
issn = "1055-9965",
publisher = "American Association for Cancer Research Inc.",
number = "3",

}

TY - JOUR

T1 - A common genetic variant in FCGR3A-V158F and risk of Kaposi sarcoma herpesvirus infection and classic Kaposi sarcoma

AU - Brown, Elizabeth E.

AU - Fallin, M. Daniele

AU - Goedert, James J.

AU - Chen, Renee

AU - Whitby, Denise

AU - Foster, Charles B.

AU - Lauria, Carmela

AU - Alberg, Anthony J.

AU - Messina, Angelo

AU - Montella, Mauizio

AU - Rezza, Giovanni

AU - Vitale, Francesco

AU - Chanock, Stephen J.

PY - 2005/3

Y1 - 2005/3

N2 - Associations of FCGR3A among men with HIV/acquired immunodeficiency syndrome suggest that host responses affect the pathogenesis of Kaposi sarcoma herpesvirus (KSHV) infection and risk of acquired immunodeficiency syndrome-associated Kaposi sarcoma. Using DNA from two HIV seronegative case-control populations in Italy, we examined whether the functional FCGR3A-V158F variant was associated with risk of KSHV infection or classic Kaposi sarcoma (CKS). In population I, we examined FCGR3A variants and risk of KSHV infection in 34 KSHV latent nuclear antigen (LANA)-seropositive and 120 LANA-seronegative adults from Sardinia (52% male; median age, 45 years; range, 31-60), whereas in population II, we examined risk of CKS from 133 CKS cases and 172 KSHV LANA-seropositive controls from Sicily, Rome, and Naples (70% males; median age, 74 years; range, 29-91). FCGK3A variants were determined by direct sequence analysis of a nested PCR of genomic DNA assay using allele-specific primers. KSHV LANA was determined by immunofluorescence assay. Overall, compared with the 158F allele, 158V was overrepresented among controls from both Mediterranean populations (frequency = 0.52 and 0.51, respectively). After controlling for age, 158V homozygous women were at increased risk of KSHV infection and CKS compared with 158F homozygous women [odds ratio (OR), 8.7; 95% confidence interval (95% CI), 0.8-98 and OR, 3.8; 95% CI, 1.0-14, respectively], whereas homozygous men were at decreased risk (OR, 0.4; 95% CI, 0.1-2.3 and OR, 0.4; 95% CI, 0.2-0.8, respectively). Significant gene-dose effects were observed among men and women at risk for CKS (Ptrend ≤ 0.05). Our findings suggest that gender differences could possibly modify the effect of FCGR3A on risk of KSHV infection and CKS. Additional studies are required to confirm these relationships and determine their etiologic significance.

AB - Associations of FCGR3A among men with HIV/acquired immunodeficiency syndrome suggest that host responses affect the pathogenesis of Kaposi sarcoma herpesvirus (KSHV) infection and risk of acquired immunodeficiency syndrome-associated Kaposi sarcoma. Using DNA from two HIV seronegative case-control populations in Italy, we examined whether the functional FCGR3A-V158F variant was associated with risk of KSHV infection or classic Kaposi sarcoma (CKS). In population I, we examined FCGR3A variants and risk of KSHV infection in 34 KSHV latent nuclear antigen (LANA)-seropositive and 120 LANA-seronegative adults from Sardinia (52% male; median age, 45 years; range, 31-60), whereas in population II, we examined risk of CKS from 133 CKS cases and 172 KSHV LANA-seropositive controls from Sicily, Rome, and Naples (70% males; median age, 74 years; range, 29-91). FCGK3A variants were determined by direct sequence analysis of a nested PCR of genomic DNA assay using allele-specific primers. KSHV LANA was determined by immunofluorescence assay. Overall, compared with the 158F allele, 158V was overrepresented among controls from both Mediterranean populations (frequency = 0.52 and 0.51, respectively). After controlling for age, 158V homozygous women were at increased risk of KSHV infection and CKS compared with 158F homozygous women [odds ratio (OR), 8.7; 95% confidence interval (95% CI), 0.8-98 and OR, 3.8; 95% CI, 1.0-14, respectively], whereas homozygous men were at decreased risk (OR, 0.4; 95% CI, 0.1-2.3 and OR, 0.4; 95% CI, 0.2-0.8, respectively). Significant gene-dose effects were observed among men and women at risk for CKS (Ptrend ≤ 0.05). Our findings suggest that gender differences could possibly modify the effect of FCGR3A on risk of KSHV infection and CKS. Additional studies are required to confirm these relationships and determine their etiologic significance.

UR - http://www.scopus.com/inward/record.url?scp=20144388186&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=20144388186&partnerID=8YFLogxK

U2 - 10.1158/1055-9965.EPI-04-0598

DO - 10.1158/1055-9965.EPI-04-0598

M3 - Article

C2 - 15767342

AN - SCOPUS:20144388186

VL - 14

SP - 633

EP - 637

JO - Cancer Epidemiology Biomarkers and Prevention

JF - Cancer Epidemiology Biomarkers and Prevention

SN - 1055-9965

IS - 3

ER -