A Common Insertion Mutation in COL7A1 in Two Italian Families with Recessive Dystrophie Epidermolysis Bullosa

Angela M. Christiano, Marina D'Alessio, Mauro Paradisi, Corrado Angelo, Cinzia Mazzanti, Pietro Puddu, Jouni Uitto

Research output: Contribution to journalArticlepeer-review

Abstract

Recessive dystrophic epidermolysis bullosa is ultrastructurally characterized by the absence of anchoring fibrils, and genetic analyses have revealed that recessive dystrophic epidermolysis bullosa results from mutations in the type VII collagen gene (COL7A1). The mutations disclosed thus far are largely family specific, with no evidence for mutational hotspot(s). In this study, we report a recurrent premature termination codon mutation detected in two apparently unrelated Italian families in different regions of the country. This mutation, 497insA in exon 4 of COL7A1, was found in combination with two different premature termination codon mutations in these families. Haplotype analysis suggested a shared genetic background in the allele containing the mutation 497insA, suggesting that this genetic lesion may represent an ancestral mutation within the Italian gene pool.

Original languageEnglish
Pages (from-to)679-684
Number of pages6
JournalJournal of Investigative Dermatology
Volume106
Issue number4
Publication statusPublished - 1996

Keywords

  • Haplotype analysis
  • Premature termination codon mutations
  • Recessive dystrophic epidermolysis bullosa
  • Type VII collagen mutations

ASJC Scopus subject areas

  • Dermatology

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