A community outbreak of haemolytic-uraemic syndrome in children occurring in a large area of Northern Italy over a period of several months

A. E. Tozzi, A. Niccolini, A. Caprioli, I. Luzzi, G. Montini, G. Zacchello, A. Gianviti, F. Principato, G. Rizzoni

Research output: Contribution to journalArticle

Abstract

From March to October 1993. 15 cases of haemolytic-uraemic syndrome (HUS) in children were detected in a large area of northern Italy, where only 8 cases had occurred in the previous 5 years. Analysis of stool and serum specimens obtained from 14 cases showed evidence of Verotoxin-producing Escherichia coli (VTEC) infection in 13. Serum antibodies to the E. coli O157 lipopolysaccharide (LPS) were found in 8 patients and to the O111 LPS in 2. An O86 VTEC was isolated from another patient. Fourteen children needed dialysis, and 1 died. No obvious epidemiologic link was observed among cases, most of whom lived in small townships. A case-control study did not show an association between HUS and food or exposure to cattle, but suggested an association with contact with chicken coops (OR = 6·5. 95% C.I. 1·2–34·9). However, VTEC were not isolated from stool samples obtained from the chicken coops involved. The risk factors for VTEC infection related to living in rural settlements, including the exposure to live poultry, should be considered in outbreak investigations.

Original languageEnglish
Pages (from-to)209-219
Number of pages11
JournalEpidemiology and Infection
Volume113
Issue number2
DOIs
Publication statusPublished - 1994

ASJC Scopus subject areas

  • Infectious Diseases
  • Epidemiology
  • Immunology
  • Public Health, Environmental and Occupational Health

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