A compact and disposable transdermal drug delivery system

M. Matteucci; M. Casella; M. Bedoni; E. Donetti; M. Fanetti; F. De Angelis; F. Gramatica; E. Di Fabrizio

doi:10.1016/j.mee.2007.12.067

A compact and disposable transdermal drug delivery system

M. Matteucci, M. Casella, M. Bedoni, E. Donetti, M. Fanetti, F. De Angelis, F. Gramatica, E. Di Fabrizio

Fondazione Don Carlo Gnocchi Onlus

Research output: Contribution to journal › Article › peer-review

Abstract

This work presents a portable transdermal drug delivery system that combines a magnetically actuated micro gear pump with a microneedle array. Micropart fabrication is performed through DXRL and LIGA techniques. The manufacturing process of both micropump and microneedle array are described together with wear issues. Results show that the assembled device can deliver rates that go from 0.1 to 1.2 ml/min at gear speed ranging from 1000 to 8500 rpm. First skin piercing experiments are also described.

Original language	English
Pages (from-to)	1066-1073
Number of pages	8
Journal	Microelectronic Engineering
Volume	85
Issue number	5-6
DOIs	https://doi.org/10.1016/j.mee.2007.12.067
Publication status	Published - May 2008

Keywords

Deep X-ray lithography
LIGA
Soft lithography
Transdermal drug delivery

ASJC Scopus subject areas

Hardware and Architecture
Electrical and Electronic Engineering
Electronic, Optical and Magnetic Materials
Surfaces, Coatings and Films
Atomic and Molecular Physics, and Optics

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10.1016/j.mee.2007.12.067

Cite this

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title = "A compact and disposable transdermal drug delivery system",

abstract = "This work presents a portable transdermal drug delivery system that combines a magnetically actuated micro gear pump with a microneedle array. Micropart fabrication is performed through DXRL and LIGA techniques. The manufacturing process of both micropump and microneedle array are described together with wear issues. Results show that the assembled device can deliver rates that go from 0.1 to 1.2 ml/min at gear speed ranging from 1000 to 8500 rpm. First skin piercing experiments are also described.",

keywords = "Deep X-ray lithography, LIGA, Soft lithography, Transdermal drug delivery",

author = "M. Matteucci and M. Casella and M. Bedoni and E. Donetti and M. Fanetti and {De Angelis}, F. and F. Gramatica and {Di Fabrizio}, E.",

year = "2008",

month = may,

doi = "10.1016/j.mee.2007.12.067",

language = "English",

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T1 - A compact and disposable transdermal drug delivery system

AU - Matteucci, M.

AU - Casella, M.

AU - Bedoni, M.

AU - Donetti, E.

AU - Fanetti, M.

AU - De Angelis, F.

AU - Gramatica, F.

AU - Di Fabrizio, E.

PY - 2008/5

Y1 - 2008/5

N2 - This work presents a portable transdermal drug delivery system that combines a magnetically actuated micro gear pump with a microneedle array. Micropart fabrication is performed through DXRL and LIGA techniques. The manufacturing process of both micropump and microneedle array are described together with wear issues. Results show that the assembled device can deliver rates that go from 0.1 to 1.2 ml/min at gear speed ranging from 1000 to 8500 rpm. First skin piercing experiments are also described.

AB - This work presents a portable transdermal drug delivery system that combines a magnetically actuated micro gear pump with a microneedle array. Micropart fabrication is performed through DXRL and LIGA techniques. The manufacturing process of both micropump and microneedle array are described together with wear issues. Results show that the assembled device can deliver rates that go from 0.1 to 1.2 ml/min at gear speed ranging from 1000 to 8500 rpm. First skin piercing experiments are also described.

KW - Deep X-ray lithography

KW - LIGA

KW - Soft lithography

KW - Transdermal drug delivery

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VL - 85

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EP - 1073

JO - Microelectronic Engineering

JF - Microelectronic Engineering

SN - 0167-9317

IS - 5-6

ER -

A compact and disposable transdermal drug delivery system

Abstract

Keywords

ASJC Scopus subject areas

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