A Comparative Assessment of Quality of Life in Patients with Multiple Myeloma Undergoing Autologous Stem Cell Transplantation Through an Outpatient and Inpatient Model

Massimo Martino, Sabino Ciavarella, Simona De Summa, Letteria Russo, Nicola Meliambro, Lucrezia Imbalzano, Giuseppe Alberto Gallo, Tiziana Moscato, Giuseppe Messina, Anna Ferreri, Maria Cuzzola, Giuseppe Irrera, Virginia Naso, Michele Cimminiello, Giuseppe Console, Giacomo Loseto, Stefania Tommasi, Attilio Guarini

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Outpatient autologous stem cell transplantation (ASCT) has proven to be feasible in terms of physical morbidity and mortality outcomes, but little data exist on the impact of this procedure on quality of life (QoL). The purpose of this prospective, observational, longitudinal cohort study was to compare the effects of inpatient (n = 76) and outpatient (n = 64) modes of care on QoL in patients with multiple myeloma who underwent ASCT. Patients were treated according to their preference for the inpatient or outpatient model. QoL was assessed using the Functional Assessment of Cancer Therapy-Bone Marrow Transplantation (FACT-BMT) at baseline (7 days before ASCT; T1) and at days +7 (T2) and +30 (T3) after ASCT. Overall, inpatients achieved higher mean values at each time point (86.05 ± 15.54 at T1, 89.23 ± 19.19 at T2, and 87.96 ± 13.6 at T3) compared with outpatients (85.62 ± 14.51 at T1, 87.42 ± 23.41 at T2, and 83.98 ± 20.2 at T3), although the differences did not reach statistical significance. Inpatients showed higher mean scores than outpatients in physical well-being (7.67 ± 5.7, 15.44 ± 6.34, and 12.96 ± 6.03, respectively, versus 5.89 ± 4.33, 13.92 ± 7.05, and 8.84 ± 6.33, respectively; P < .05). Mean scores on social/family well-being were significantly higher in the outpatient group compared with the inpatient group (22.93 ± 13.29, 21.14 ± 5.31, and 21.64 ± 4.58, respectively, versus 20.59 ± 3.79, 19.52 ± 5.12, and 20.01 ± 3.97, respectively; P = .003). There were no significant between-group differences with respect to functional well-being and emotional status. Among adults at a single institution undergoing ASCT for MM, the use of outpatient care compared with standard transplantation care did not result in improved QoL during transplantation. Further research is needed for replication and to assess longer-term outcomes and implications.

Original languageEnglish
Pages (from-to)608-613
Number of pages6
JournalBiology of Blood and Marrow Transplantation
Volume24
Issue number3
DOIs
Publication statusPublished - Jan 30 2018

Fingerprint

Stem Cell Transplantation
Multiple Myeloma
Inpatients
Outpatients
Quality of Life
Transplantation
Bone Neoplasms
Ambulatory Care
Bone Marrow Transplantation
Longitudinal Studies
Cohort Studies
Morbidity
Mortality
Research

Keywords

  • ASCT
  • Inpatient
  • Multiple myeloma
  • Outpatient
  • Quality of life

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this

A Comparative Assessment of Quality of Life in Patients with Multiple Myeloma Undergoing Autologous Stem Cell Transplantation Through an Outpatient and Inpatient Model. / Martino, Massimo; Ciavarella, Sabino; De Summa, Simona; Russo, Letteria; Meliambro, Nicola; Imbalzano, Lucrezia; Gallo, Giuseppe Alberto; Moscato, Tiziana; Messina, Giuseppe; Ferreri, Anna; Cuzzola, Maria; Irrera, Giuseppe; Naso, Virginia; Cimminiello, Michele; Console, Giuseppe; Loseto, Giacomo; Tommasi, Stefania; Guarini, Attilio.

In: Biology of Blood and Marrow Transplantation, Vol. 24, No. 3, 30.01.2018, p. 608-613.

Research output: Contribution to journalArticle

Martino, M, Ciavarella, S, De Summa, S, Russo, L, Meliambro, N, Imbalzano, L, Gallo, GA, Moscato, T, Messina, G, Ferreri, A, Cuzzola, M, Irrera, G, Naso, V, Cimminiello, M, Console, G, Loseto, G, Tommasi, S & Guarini, A 2018, 'A Comparative Assessment of Quality of Life in Patients with Multiple Myeloma Undergoing Autologous Stem Cell Transplantation Through an Outpatient and Inpatient Model', Biology of Blood and Marrow Transplantation, vol. 24, no. 3, pp. 608-613. https://doi.org/10.1016/j.bbmt.2017.09.021
Martino, Massimo ; Ciavarella, Sabino ; De Summa, Simona ; Russo, Letteria ; Meliambro, Nicola ; Imbalzano, Lucrezia ; Gallo, Giuseppe Alberto ; Moscato, Tiziana ; Messina, Giuseppe ; Ferreri, Anna ; Cuzzola, Maria ; Irrera, Giuseppe ; Naso, Virginia ; Cimminiello, Michele ; Console, Giuseppe ; Loseto, Giacomo ; Tommasi, Stefania ; Guarini, Attilio. / A Comparative Assessment of Quality of Life in Patients with Multiple Myeloma Undergoing Autologous Stem Cell Transplantation Through an Outpatient and Inpatient Model. In: Biology of Blood and Marrow Transplantation. 2018 ; Vol. 24, No. 3. pp. 608-613.
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T1 - A Comparative Assessment of Quality of Life in Patients with Multiple Myeloma Undergoing Autologous Stem Cell Transplantation Through an Outpatient and Inpatient Model

AU - Martino, Massimo

AU - Ciavarella, Sabino

AU - De Summa, Simona

AU - Russo, Letteria

AU - Meliambro, Nicola

AU - Imbalzano, Lucrezia

AU - Gallo, Giuseppe Alberto

AU - Moscato, Tiziana

AU - Messina, Giuseppe

AU - Ferreri, Anna

AU - Cuzzola, Maria

AU - Irrera, Giuseppe

AU - Naso, Virginia

AU - Cimminiello, Michele

AU - Console, Giuseppe

AU - Loseto, Giacomo

AU - Tommasi, Stefania

AU - Guarini, Attilio

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N2 - Outpatient autologous stem cell transplantation (ASCT) has proven to be feasible in terms of physical morbidity and mortality outcomes, but little data exist on the impact of this procedure on quality of life (QoL). The purpose of this prospective, observational, longitudinal cohort study was to compare the effects of inpatient (n = 76) and outpatient (n = 64) modes of care on QoL in patients with multiple myeloma who underwent ASCT. Patients were treated according to their preference for the inpatient or outpatient model. QoL was assessed using the Functional Assessment of Cancer Therapy-Bone Marrow Transplantation (FACT-BMT) at baseline (7 days before ASCT; T1) and at days +7 (T2) and +30 (T3) after ASCT. Overall, inpatients achieved higher mean values at each time point (86.05 ± 15.54 at T1, 89.23 ± 19.19 at T2, and 87.96 ± 13.6 at T3) compared with outpatients (85.62 ± 14.51 at T1, 87.42 ± 23.41 at T2, and 83.98 ± 20.2 at T3), although the differences did not reach statistical significance. Inpatients showed higher mean scores than outpatients in physical well-being (7.67 ± 5.7, 15.44 ± 6.34, and 12.96 ± 6.03, respectively, versus 5.89 ± 4.33, 13.92 ± 7.05, and 8.84 ± 6.33, respectively; P < .05). Mean scores on social/family well-being were significantly higher in the outpatient group compared with the inpatient group (22.93 ± 13.29, 21.14 ± 5.31, and 21.64 ± 4.58, respectively, versus 20.59 ± 3.79, 19.52 ± 5.12, and 20.01 ± 3.97, respectively; P = .003). There were no significant between-group differences with respect to functional well-being and emotional status. Among adults at a single institution undergoing ASCT for MM, the use of outpatient care compared with standard transplantation care did not result in improved QoL during transplantation. Further research is needed for replication and to assess longer-term outcomes and implications.

AB - Outpatient autologous stem cell transplantation (ASCT) has proven to be feasible in terms of physical morbidity and mortality outcomes, but little data exist on the impact of this procedure on quality of life (QoL). The purpose of this prospective, observational, longitudinal cohort study was to compare the effects of inpatient (n = 76) and outpatient (n = 64) modes of care on QoL in patients with multiple myeloma who underwent ASCT. Patients were treated according to their preference for the inpatient or outpatient model. QoL was assessed using the Functional Assessment of Cancer Therapy-Bone Marrow Transplantation (FACT-BMT) at baseline (7 days before ASCT; T1) and at days +7 (T2) and +30 (T3) after ASCT. Overall, inpatients achieved higher mean values at each time point (86.05 ± 15.54 at T1, 89.23 ± 19.19 at T2, and 87.96 ± 13.6 at T3) compared with outpatients (85.62 ± 14.51 at T1, 87.42 ± 23.41 at T2, and 83.98 ± 20.2 at T3), although the differences did not reach statistical significance. Inpatients showed higher mean scores than outpatients in physical well-being (7.67 ± 5.7, 15.44 ± 6.34, and 12.96 ± 6.03, respectively, versus 5.89 ± 4.33, 13.92 ± 7.05, and 8.84 ± 6.33, respectively; P < .05). Mean scores on social/family well-being were significantly higher in the outpatient group compared with the inpatient group (22.93 ± 13.29, 21.14 ± 5.31, and 21.64 ± 4.58, respectively, versus 20.59 ± 3.79, 19.52 ± 5.12, and 20.01 ± 3.97, respectively; P = .003). There were no significant between-group differences with respect to functional well-being and emotional status. Among adults at a single institution undergoing ASCT for MM, the use of outpatient care compared with standard transplantation care did not result in improved QoL during transplantation. Further research is needed for replication and to assess longer-term outcomes and implications.

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