A comparative in-vitro evaluation of resistance selection after exposure to teicoplanin, vancomycin, linezolid and quinupristin-dalfopristin in Staphylococcus aureus and Enterococcus spp

Lorenzo Drago, L. Nicola, E. De Vecchi

Research output: Contribution to journalArticle

Abstract

The ability of breakpoint and serum concentrations of teicoplanin, vancomycin, linezolid and quinupristin-dalfopristin to select resistance was compared for isolates of methicillin-susceptible Staphylococcus aureus (MSSA), methicillin-resistant S. aureus (MRSA), Enterococcus faecalis and Enterococcus faecium. Mutation frequencies were always -10, except for two isolates grown in the presence of teicoplanin at the trough serum concentration. After multistep selection, linezolid selected for resistance in staphylococci and enterococci, and serial exposure to certain concentrations of linezolid was more likely to select for stable resistance in MRSA, MSSA and enterococci than was exposure to glycopeptides and quinupristin-dalfopristin.

Original languageEnglish
Pages (from-to)608-611
Number of pages4
JournalClinical Microbiology and Infection
Volume14
Issue number6
DOIs
Publication statusPublished - Jun 2008

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Keywords

  • Enterococci
  • Glycopeptides
  • Linezolid
  • Quinupristin-dalfopristin
  • Resistance selection
  • Staphylococcus aureus

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

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