A comparative study between conventional and laparoscopic cholecystectomy: Evaluation of phagocytic and T-cell-mediated antibacterial activities

Maria Altamura, Angela Tafaro, Daniela Casale, Maria Pepe, Rosa Colella, Emilio Jirillo, Pietro Venezia

Research output: Contribution to journalArticle

Abstract

Over the past few years, many reports have pointed out that open, but not minimally invasive, cholecystectomy was associated with reduced immune functions. Also, after laparoscopic surgery, a reduced impairment of T cell functions and lower levels of proinflammatory cytokines, epinephrine, and norepinephrine were found in comparison with those detected in patients who underwent conventional cholecystectomy. We investigated polymorphonuclear cell- and monocyte-mediated phagocytosis and killing and T-cell-mediated antibacterial activity in 12 patients who underwent open cholecystectomy versus another group of 12 patients who underwent laparoscopic cholecystectomy. Our data show that polymorphonuclear and monocyte killing activities are preserved or are less affected in patients who undergo laparoscopy when compared with patients who undergo conventional operation. On the other hand, in both groups of patients, T-cell-mediated antibacterial activity was significantly reduced in the preoperative period, and, therefore, we could not draw conclusions on the effects of the surgical techniques used on the above immune parameter. The overall data suggest that laparoscopic cholecystectomy is a valid alternative to open surgery because of the moderate postoperative immune suppression and decreased risk of postsurgical infections.

Original languageEnglish
Pages (from-to)135-140
Number of pages6
JournalJournal of Clinical Gastroenterology
Volume34
Issue number2
DOIs
Publication statusPublished - 2002

Fingerprint

Laparoscopic Cholecystectomy
Phagocytes
T-Lymphocytes
Cholecystectomy
Laparoscopy
Monocytes
Preoperative Period
Phagocytosis
Epinephrine
Norepinephrine
Cytokines
Infection

Keywords

  • Laparoscopic cholecystectomy
  • Lymphocytes
  • Monocytes
  • Open cholecystectomy
  • Polymorphonuclear cells

ASJC Scopus subject areas

  • Gastroenterology

Cite this

A comparative study between conventional and laparoscopic cholecystectomy : Evaluation of phagocytic and T-cell-mediated antibacterial activities. / Altamura, Maria; Tafaro, Angela; Casale, Daniela; Pepe, Maria; Colella, Rosa; Jirillo, Emilio; Venezia, Pietro.

In: Journal of Clinical Gastroenterology, Vol. 34, No. 2, 2002, p. 135-140.

Research output: Contribution to journalArticle

Altamura, Maria ; Tafaro, Angela ; Casale, Daniela ; Pepe, Maria ; Colella, Rosa ; Jirillo, Emilio ; Venezia, Pietro. / A comparative study between conventional and laparoscopic cholecystectomy : Evaluation of phagocytic and T-cell-mediated antibacterial activities. In: Journal of Clinical Gastroenterology. 2002 ; Vol. 34, No. 2. pp. 135-140.
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