A comparative study of the cutaneous side effects between BRAF monotherapy and BRAF/MEK inhibitor combination therapy in patients with advanced melanoma: A single-centre experience

Irene Russo, Ludovica Zorzetto, Anna Chiara Frigo, Vanna Chiarion Sileni, Mauro Alaibac

Research output: Contribution to journalArticle

Abstract

Background: Patients with advanced melanoma have a poor prognosis. Since the discovery of BRAF mutations in cutaneous melanoma, new pharmacological agents have been developed to inhibit this target. Although the survival of patients with advanced melanoma has improved with BRAF inhibitors, the emergence of drug resistance and the high incidence of cutaneous side effects represent important limitations. Objectives: The aim of our study was to compare the incidence of cutaneous side effects between BRAF inhibitor monotherapy and BRAF and MEK inhibitor combination therapy in our cohort of patients. Materials & methods: This studywas a longitudinal prospective observational study. The study population comprised 83 patients with advanced cutaneous melanoma presenting with BRAF V600 mutation. The inclusion criteria included: age above 18 years, metastatic cutaneous melanoma or melanoma with high risk of metastasis, the presence of BRAF V600 mutation, and treatment withBRAFinhibitors or a combination ofBRAF and MEK inhibitors. Results: The majority of patients developed skin toxicity during treatment. The most common cutaneous side effects were localized hyperkeratosis and verrucous keratosis. Other cutaneous side effects observed were photosensitivity, squamous cell carcinoma, and keratoacanthoma. Conclusion: Our results indicate that cutaneous side effects are generally observed during BRAF inhibitor monotherapy and are significantly different from those observed in patients treated with combination therapy.

Original languageEnglish
Pages (from-to)482-486
Number of pages5
JournalEuropean Journal of Dermatology
Volume27
Issue number5
DOIs
Publication statusPublished - Sep 1 2017

Keywords

  • BRAF inhibitor
  • Cutaneous side effect
  • MEK inhibitor
  • Melanoma

ASJC Scopus subject areas

  • Dermatology

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