A Comparison Among Different Automatically Segmented Slabs to Assess Neovascular AMD using Swept Source OCT Angiography

Mariacristina Parravano, Enrico Borrelli, Riccardo Sacconi, Eliana Costanzo, Alessandro Marchese, Daniela Manca, Monica Varano, Francesco Bandello, Giuseppe Querques

Research output: Contribution to journalArticlepeer-review


PURPOSE: We systematically compare the intermodality and interreader agreement in age-related macular degeneration(AMD)-associated neovascularization assessment for optical coherence tomography angiography (OCTA) images obtained using different slabs. METHODS: We collected data from 48 patients (50 eyes) with type 1 or 2 neovascularization (NV) and AMD. Subjects were imaged with a swept source (SS)-OCTA system. For each eye, three OCTA en face images generated from three different slabs were exported: (1) the outer retina to choriocapillaris (ORCC) image, (2) the choriocapillaris (CC) image, and (3) the retinal pigment epithelium (RPE)-RPE fit image. Each image was graded by two readers to assess interreader variability and a single image for each modality was used to assess the intermodality variability. RESULTS: In the assessment of type 1 NV, mean absolute interreader difference between measured NV areas was 0.19, 0.30, and 0.16 mm(2) for ORCC, CC, and RPE-RPE fit images, respectively. Similarly, the coefficient of repeatability (CR) and intraclass correlation coefficient (ICC) indicated that the RPE-RPE fit assessment was characterized by the highest interreader reproducibility. Type 1 NV size was 0.58 mm(2) (0.30-1.60 mm(2)) on ORCC images, 0.00 mm(2) (0.00-0.36 mm(2)) on CC images (P = 0.002 vs. ORCC), and 0.62 mm(2) (0.31-2.03 mm(2)) on RPE-RPE fit images (P <0.0001 vs. CC, P = 0.041 vs. ORCC). CONCLUSIONS: The RPE-RPE fit OCTA images have the highest interreader agreement and deliver larger measurements in type 1 lesions. TRANSLATIONAL RELEVANCE: OCTA imaging may be used in ongoing trials of potential novel treatments for NV.
Original languageEnglish
Pages (from-to)8
Number of pages1
JournalTranslational Vision Science and Technology
Issue number2
Publication statusPublished - Mar 27 2019


  • AMD
  • OCTA
  • neovascular
  • neovascularization


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