A comparison between c lonidine and ketamine effects as caudal additives to 0.2% ropivac aine in children

Negri De Pasquale, Visconti Giro, Giorgio Ivani, Borrelli Felice, Paolo De Vivo

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INTRODUCTION. The technique of caudal anesthesia with a local anesthetic to provide intraoperative analgesia which persists into the postoperative period to prevent the establishment of pain hypersensitivity, is one of the commonest analgesic techniques used in pédiatrie anesthesia. It has been previously demonstrated that addition of low-dose ketamine hydrochloride , an NMDA receptor antagonist, to bupivacaine for caudal block in children significantly prolongs the duration of postop analgesia and reduces the requirement for analgesics to a greater extent if compared to adrenaline or clonidine (1). Ropivacaine 0.2% provides a superior analgesia in terms of duration and quality if compared to 0.25% bupivacaine in children (2.3): the concomitant administration of clonidine gives a superior analgesia too (4). Aim of our study was to prospectively study and compare the quality and duration of postop analgesia obtained from caudal block with an equal volume of 0.2 % ropivacaine alone and 0.2 % ropivacaine with clonidine or ketamine in pédiatrie patients undergoing minor urologie surgery. METHODS. After IRB approval and written parental informed consent, we enrolled in our prospective, randomized, double blind study 45 inpatients. ASA I, aged 1-5 years, weight 11- 45 kg , undergoing hernia repair or orchidopexy (mean duration 38 ±10 min). Children received no premedication. General anesthesia was induced with halothane and maintained with isoflurane in O2/air mixture throughout surgery ; all patients maintained spontaneous breathing. Caudal block was then performed in a left lateral position with a Tuohy 19G needle (Sevit

Original languageEnglish
Pages (from-to)38
Number of pages1
JournalRegional Anesthesia and Pain Medicine
Issue number2 SUPPL.
Publication statusPublished - 2000

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


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