A comparison between nailfold capillaroscopy patterns in adulthood in juvenile and adult-onset systemic sclerosis: A EUSTAR exploratory study

Francesca Ingegnoli, Patrizia Boracchi, Roberta Gualtierotti, Vanessa Smith, Maurizio Cutolo, Ivan Foeldvari, Paolo Airò, Juan Jose Alegre-Sancho, Yannick Allanore, Lidia P. Ananieva, Codrina Ancuta, Luis Eduardo Andrade, Martin Aringer, Radim Becvar, Mihai Bojinca, Irena Butrimiene, Francesco Paolo Cantatore, Roberto Caporali, Paola Caramaschi, Patricia E. CarreiraRodica Chirieac, Ada Corrado, Vanesa Cosentino, Giovanna Cuomo, Laszlo Czirjak, José Antonio Pereira Da Silva, Paloma García de la Peña Lefebvre, Filip De Keyser, Carolina de Souza Müller, Kirsten Damgaard, Nemanja Damjanov, Lev N. Denisov, Oliver Distler, Alan Doube, Alina Dumitrascu, Merete Engelhart, Marta Valero Exposito, Kilian Eyerich, Dominique Farge-Bancel, Valderílio Feijó Azevedo, Rosario Foti, Marc Frerix, Armando Gabrielli, Torhild Garen, Paola Gottschalk, Laura Groseanu, Serena Guiducci, Claudia Günther, Eric Hachulla, Rüdiger Hein, Stefan Heitmann, Jörg Henes, Roger Hesselstrand, John Highton, Florenzo Iannone, Ruxandra Maria Ionescu, Cristiane Kayser, Diana Karpec, Eduardo Kerzberg, Anna Kotulska, Magdalena Kopec-Medrek, Eugene Kucharz, Brigitte Krummel-Lorenz, Felix Lauffer, David Launay, Mengtao Li, Ira Litinsky, Esthela Loyo, Marco Matucci Cerinic, Pierluigi Meroni, Øyvind Midtvedt, Carmen Marina Mihai, Carlomaurizio Montecucco, Fabiana Montoya, Ewa Morgiel, Luc Mouthon, Ulf Müller-Ladner, Henrik Nielsen, Daniela Opris, Vera Ortiz-Santamaria, Kati Otsa, Margarita Pileckyte, Simonetta Pisarri, Monica Popescu, Maria Rosa Pozzi, Francesco Puppo, Sebastião Cezar Radominski, Valeria Riccieri, Edoardo Rosato, Blaz Rozman, Silvia Rodriguez Rubio, Rita Rugiene, Petra Saar, Maria João Salvador, Matthias Seidel, Renata Sokolik, Kamal Solanki, Bojana Stamenkovic, Aleksandra Stankovic, Simon Stebbings, Gitte Strauss, Alberto Sulli, Szilvia Szamosi, Jacek Szechinski, Magdalena Szmyrka-Kaczmarek, Gabriella Szücs, Cristina Mihaela Tanaseanu, Isabela Tiglea, Alan Tyndall, Nicola Ughi, Maria Uprus, Alessandra Vacca, Cecilia Varju, Algirdas Venalis, Paulius Venalis, Ulrich A. Walker, Malgorzata Widuchowska, Piotr Wiland, Dirk M. Wuttge, Silvana Zeni, Thierry Zenone

Research output: Contribution to journalArticle

Abstract

Objective: Qualitative capillaroscopy patterns in juvenile- and adult-onset systemic sclerosis (SSc) were studied in adulthood using data from the EULAR Scleroderma Trials and Research (EUSTAR) database. Methods: Data collected between June 2004 and April 2013 were examined with focus on capillaroscopy. In this retrospective exploratory study, series of patients with juvenile-onset SSc were matched with series of adult-onset SSc having the same gender and autoantibody profile. Results: 30 of 123 patients with juvenile-onset and 2108 of 7133 with adult-onset SSc had data on capillaroscopy. Juvenile-onset SSc showed scleroderma pattern more frequently than adult-onset SSc (93.3% and 88%). The OR was 2.44 and 95% CI 0.57-10.41. An active scleroderma pattern was present in 58% of juvenile- and 61% of adult-onset SSc. The OR was 0.91 and 95% CI 0.28-2.93. The late scleroderma pattern was present in 61% of juvenile- and 55.5% of adult-onset SSc. The OR was 1.06 and 95% CI 0.34-3.56. Conclusion: This is the first exploratory study on the comparison of capillaroscopy between juvenile- and adult-onset SSc in adulthood. Juvenile-onset SSc had an increase prevalence of scleroderma pattern, but a similar distribution of the three patterns was suggested. Further studies are needed to define this issue.

Original languageEnglish
Pages (from-to)19-24
Number of pages6
JournalMicrovascular Research
Volume102
DOIs
Publication statusPublished - Nov 1 2015

Keywords

  • Capillaroscopy
  • EUSTAR
  • Juvenile systemic sclerosis
  • Microcirculation
  • Nailfold capillaroscopy
  • Systemic sclerosis
  • Videocapillaroscopy

ASJC Scopus subject areas

  • Biochemistry
  • Cardiology and Cardiovascular Medicine
  • Cell Biology

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    Ingegnoli, F., Boracchi, P., Gualtierotti, R., Smith, V., Cutolo, M., Foeldvari, I., Airò, P., Alegre-Sancho, J. J., Allanore, Y., Ananieva, L. P., Ancuta, C., Andrade, L. E., Aringer, M., Becvar, R., Bojinca, M., Butrimiene, I., Cantatore, F. P., Caporali, R., Caramaschi, P., ... Zenone, T. (2015). A comparison between nailfold capillaroscopy patterns in adulthood in juvenile and adult-onset systemic sclerosis: A EUSTAR exploratory study. Microvascular Research, 102, 19-24. https://doi.org/10.1016/j.mvr.2015.07.007