A comparison between nailfold capillaroscopy patterns in adulthood in juvenile and adult-onset systemic sclerosis: A EUSTAR exploratory study

Francesca Ingegnoli, Patrizia Boracchi, Roberta Gualtierotti, Vanessa Smith, Maurizio Cutolo, Ivan Foeldvari, Paolo Airò, Juan Jose Alegre-Sancho, Yannick Allanore, Lidia P. Ananieva, Codrina Ancuta, Luis Eduardo Andrade, Martin Aringer, Radim Becvar, Mihai Bojinca, Irena Butrimiene, Francesco Paolo Cantatore, Roberto Caporali, Paola Caramaschi, Patricia E. CarreiraRodica Chirieac, Ada Corrado, Vanesa Cosentino, Giovanna Cuomo, Laszlo Czirjak, José Antonio Pereira Da Silva, Paloma García de la Peña Lefebvre, Filip De Keyser, Carolina de Souza Müller, Kirsten Damgaard, Nemanja Damjanov, Lev N. Denisov, Oliver Distler, Alan Doube, Alina Dumitrascu, Merete Engelhart, Marta Valero Exposito, Kilian Eyerich, Dominique Farge-Bancel, Valderílio Feijó Azevedo, Rosario Foti, Marc Frerix, Armando Gabrielli, Torhild Garen, Paola Gottschalk, Laura Groseanu, Serena Guiducci, Claudia Günther, Eric Hachulla, Rüdiger Hein, Stefan Heitmann, Jörg Henes, Roger Hesselstrand, John Highton, Florenzo Iannone, Ruxandra Maria Ionescu, Cristiane Kayser, Diana Karpec, Eduardo Kerzberg, Anna Kotulska, Magdalena Kopec-Medrek, Eugene Kucharz, Brigitte Krummel-Lorenz, Felix Lauffer, David Launay, Mengtao Li, Ira Litinsky, Esthela Loyo, Marco Matucci Cerinic, Pierluigi Meroni, Øyvind Midtvedt, Carmen Marina Mihai, Carlomaurizio Montecucco, Fabiana Montoya, Ewa Morgiel, Luc Mouthon, Ulf Müller-Ladner, Henrik Nielsen, Daniela Opris, Vera Ortiz-Santamaria, Kati Otsa, Margarita Pileckyte, Simonetta Pisarri, Monica Popescu, Maria Rosa Pozzi, Francesco Puppo, Sebastião Cezar Radominski, Valeria Riccieri, Edoardo Rosato, Blaz Rozman, Silvia Rodriguez Rubio, Rita Rugiene, Petra Saar, Maria João Salvador, Matthias Seidel, Renata Sokolik, Kamal Solanki, Bojana Stamenkovic, Aleksandra Stankovic, Simon Stebbings, Gitte Strauss, Alberto Sulli, Szilvia Szamosi, Jacek Szechinski, Magdalena Szmyrka-Kaczmarek, Gabriella Szücs, Cristina Mihaela Tanaseanu, Isabela Tiglea, Alan Tyndall, Nicola Ughi, Maria Uprus, Alessandra Vacca, Cecilia Varju, Algirdas Venalis, Paulius Venalis, Ulrich A. Walker, Malgorzata Widuchowska, Piotr Wiland, Dirk M. Wuttge, Silvana Zeni, Thierry Zenone

Research output: Contribution to journalArticle

Abstract

Objective: Qualitative capillaroscopy patterns in juvenile- and adult-onset systemic sclerosis (SSc) were studied in adulthood using data from the EULAR Scleroderma Trials and Research (EUSTAR) database. Methods: Data collected between June 2004 and April 2013 were examined with focus on capillaroscopy. In this retrospective exploratory study, series of patients with juvenile-onset SSc were matched with series of adult-onset SSc having the same gender and autoantibody profile. Results: 30 of 123 patients with juvenile-onset and 2108 of 7133 with adult-onset SSc had data on capillaroscopy. Juvenile-onset SSc showed scleroderma pattern more frequently than adult-onset SSc (93.3% and 88%). The OR was 2.44 and 95% CI 0.57-10.41. An active scleroderma pattern was present in 58% of juvenile- and 61% of adult-onset SSc. The OR was 0.91 and 95% CI 0.28-2.93. The late scleroderma pattern was present in 61% of juvenile- and 55.5% of adult-onset SSc. The OR was 1.06 and 95% CI 0.34-3.56. Conclusion: This is the first exploratory study on the comparison of capillaroscopy between juvenile- and adult-onset SSc in adulthood. Juvenile-onset SSc had an increase prevalence of scleroderma pattern, but a similar distribution of the three patterns was suggested. Further studies are needed to define this issue.

Original languageEnglish
Pages (from-to)19-24
Number of pages6
JournalMicrovascular Research
Volume102
DOIs
Publication statusPublished - Nov 1 2015

Fingerprint

Microscopic Angioscopy
Systemic Scleroderma
Research
Autoantibodies
Retrospective Studies

Keywords

  • Capillaroscopy
  • EUSTAR
  • Juvenile systemic sclerosis
  • Microcirculation
  • Nailfold capillaroscopy
  • Systemic sclerosis
  • Videocapillaroscopy

ASJC Scopus subject areas

  • Biochemistry
  • Cardiology and Cardiovascular Medicine
  • Cell Biology

Cite this

A comparison between nailfold capillaroscopy patterns in adulthood in juvenile and adult-onset systemic sclerosis : A EUSTAR exploratory study. / Ingegnoli, Francesca; Boracchi, Patrizia; Gualtierotti, Roberta; Smith, Vanessa; Cutolo, Maurizio; Foeldvari, Ivan; Airò, Paolo; Alegre-Sancho, Juan Jose; Allanore, Yannick; Ananieva, Lidia P.; Ancuta, Codrina; Andrade, Luis Eduardo; Aringer, Martin; Becvar, Radim; Bojinca, Mihai; Butrimiene, Irena; Cantatore, Francesco Paolo; Caporali, Roberto; Caramaschi, Paola; Carreira, Patricia E.; Chirieac, Rodica; Corrado, Ada; Cosentino, Vanesa; Cuomo, Giovanna; Czirjak, Laszlo; Da Silva, José Antonio Pereira; de la Peña Lefebvre, Paloma García; De Keyser, Filip; de Souza Müller, Carolina; Damgaard, Kirsten; Damjanov, Nemanja; Denisov, Lev N.; Distler, Oliver; Doube, Alan; Dumitrascu, Alina; Engelhart, Merete; Exposito, Marta Valero; Eyerich, Kilian; Farge-Bancel, Dominique; Azevedo, Valderílio Feijó; Foti, Rosario; Frerix, Marc; Gabrielli, Armando; Garen, Torhild; Gottschalk, Paola; Groseanu, Laura; Guiducci, Serena; Günther, Claudia; Hachulla, Eric; Hein, Rüdiger; Heitmann, Stefan; Henes, Jörg; Hesselstrand, Roger; Highton, John; Iannone, Florenzo; Ionescu, Ruxandra Maria; Kayser, Cristiane; Karpec, Diana; Kerzberg, Eduardo; Kotulska, Anna; Kopec-Medrek, Magdalena; Kucharz, Eugene; Krummel-Lorenz, Brigitte; Lauffer, Felix; Launay, David; Li, Mengtao; Litinsky, Ira; Loyo, Esthela; Cerinic, Marco Matucci; Meroni, Pierluigi; Midtvedt, Øyvind; Mihai, Carmen Marina; Montecucco, Carlomaurizio; Montoya, Fabiana; Morgiel, Ewa; Mouthon, Luc; Müller-Ladner, Ulf; Nielsen, Henrik; Opris, Daniela; Ortiz-Santamaria, Vera; Otsa, Kati; Pileckyte, Margarita; Pisarri, Simonetta; Popescu, Monica; Pozzi, Maria Rosa; Puppo, Francesco; Radominski, Sebastião Cezar; Riccieri, Valeria; Rosato, Edoardo; Rozman, Blaz; Rubio, Silvia Rodriguez; Rugiene, Rita; Saar, Petra; Salvador, Maria João; Seidel, Matthias; Sokolik, Renata; Solanki, Kamal; Stamenkovic, Bojana; Stankovic, Aleksandra; Stebbings, Simon; Strauss, Gitte; Sulli, Alberto; Szamosi, Szilvia; Szechinski, Jacek; Szmyrka-Kaczmarek, Magdalena; Szücs, Gabriella; Tanaseanu, Cristina Mihaela; Tiglea, Isabela; Tyndall, Alan; Ughi, Nicola; Uprus, Maria; Vacca, Alessandra; Varju, Cecilia; Venalis, Algirdas; Venalis, Paulius; Walker, Ulrich A.; Widuchowska, Malgorzata; Wiland, Piotr; M. Wuttge, Dirk; Zeni, Silvana; Zenone, Thierry.

In: Microvascular Research, Vol. 102, 01.11.2015, p. 19-24.

Research output: Contribution to journalArticle

Ingegnoli, F, Boracchi, P, Gualtierotti, R, Smith, V, Cutolo, M, Foeldvari, I, Airò, P, Alegre-Sancho, JJ, Allanore, Y, Ananieva, LP, Ancuta, C, Andrade, LE, Aringer, M, Becvar, R, Bojinca, M, Butrimiene, I, Cantatore, FP, Caporali, R, Caramaschi, P, Carreira, PE, Chirieac, R, Corrado, A, Cosentino, V, Cuomo, G, Czirjak, L, Da Silva, JAP, de la Peña Lefebvre, PG, De Keyser, F, de Souza Müller, C, Damgaard, K, Damjanov, N, Denisov, LN, Distler, O, Doube, A, Dumitrascu, A, Engelhart, M, Exposito, MV, Eyerich, K, Farge-Bancel, D, Azevedo, VF, Foti, R, Frerix, M, Gabrielli, A, Garen, T, Gottschalk, P, Groseanu, L, Guiducci, S, Günther, C, Hachulla, E, Hein, R, Heitmann, S, Henes, J, Hesselstrand, R, Highton, J, Iannone, F, Ionescu, RM, Kayser, C, Karpec, D, Kerzberg, E, Kotulska, A, Kopec-Medrek, M, Kucharz, E, Krummel-Lorenz, B, Lauffer, F, Launay, D, Li, M, Litinsky, I, Loyo, E, Cerinic, MM, Meroni, P, Midtvedt, Ø, Mihai, CM, Montecucco, C, Montoya, F, Morgiel, E, Mouthon, L, Müller-Ladner, U, Nielsen, H, Opris, D, Ortiz-Santamaria, V, Otsa, K, Pileckyte, M, Pisarri, S, Popescu, M, Pozzi, MR, Puppo, F, Radominski, SC, Riccieri, V, Rosato, E, Rozman, B, Rubio, SR, Rugiene, R, Saar, P, Salvador, MJ, Seidel, M, Sokolik, R, Solanki, K, Stamenkovic, B, Stankovic, A, Stebbings, S, Strauss, G, Sulli, A, Szamosi, S, Szechinski, J, Szmyrka-Kaczmarek, M, Szücs, G, Tanaseanu, CM, Tiglea, I, Tyndall, A, Ughi, N, Uprus, M, Vacca, A, Varju, C, Venalis, A, Venalis, P, Walker, UA, Widuchowska, M, Wiland, P, M. Wuttge, D, Zeni, S & Zenone, T 2015, 'A comparison between nailfold capillaroscopy patterns in adulthood in juvenile and adult-onset systemic sclerosis: A EUSTAR exploratory study', Microvascular Research, vol. 102, pp. 19-24. https://doi.org/10.1016/j.mvr.2015.07.007
Ingegnoli, Francesca ; Boracchi, Patrizia ; Gualtierotti, Roberta ; Smith, Vanessa ; Cutolo, Maurizio ; Foeldvari, Ivan ; Airò, Paolo ; Alegre-Sancho, Juan Jose ; Allanore, Yannick ; Ananieva, Lidia P. ; Ancuta, Codrina ; Andrade, Luis Eduardo ; Aringer, Martin ; Becvar, Radim ; Bojinca, Mihai ; Butrimiene, Irena ; Cantatore, Francesco Paolo ; Caporali, Roberto ; Caramaschi, Paola ; Carreira, Patricia E. ; Chirieac, Rodica ; Corrado, Ada ; Cosentino, Vanesa ; Cuomo, Giovanna ; Czirjak, Laszlo ; Da Silva, José Antonio Pereira ; de la Peña Lefebvre, Paloma García ; De Keyser, Filip ; de Souza Müller, Carolina ; Damgaard, Kirsten ; Damjanov, Nemanja ; Denisov, Lev N. ; Distler, Oliver ; Doube, Alan ; Dumitrascu, Alina ; Engelhart, Merete ; Exposito, Marta Valero ; Eyerich, Kilian ; Farge-Bancel, Dominique ; Azevedo, Valderílio Feijó ; Foti, Rosario ; Frerix, Marc ; Gabrielli, Armando ; Garen, Torhild ; Gottschalk, Paola ; Groseanu, Laura ; Guiducci, Serena ; Günther, Claudia ; Hachulla, Eric ; Hein, Rüdiger ; Heitmann, Stefan ; Henes, Jörg ; Hesselstrand, Roger ; Highton, John ; Iannone, Florenzo ; Ionescu, Ruxandra Maria ; Kayser, Cristiane ; Karpec, Diana ; Kerzberg, Eduardo ; Kotulska, Anna ; Kopec-Medrek, Magdalena ; Kucharz, Eugene ; Krummel-Lorenz, Brigitte ; Lauffer, Felix ; Launay, David ; Li, Mengtao ; Litinsky, Ira ; Loyo, Esthela ; Cerinic, Marco Matucci ; Meroni, Pierluigi ; Midtvedt, Øyvind ; Mihai, Carmen Marina ; Montecucco, Carlomaurizio ; Montoya, Fabiana ; Morgiel, Ewa ; Mouthon, Luc ; Müller-Ladner, Ulf ; Nielsen, Henrik ; Opris, Daniela ; Ortiz-Santamaria, Vera ; Otsa, Kati ; Pileckyte, Margarita ; Pisarri, Simonetta ; Popescu, Monica ; Pozzi, Maria Rosa ; Puppo, Francesco ; Radominski, Sebastião Cezar ; Riccieri, Valeria ; Rosato, Edoardo ; Rozman, Blaz ; Rubio, Silvia Rodriguez ; Rugiene, Rita ; Saar, Petra ; Salvador, Maria João ; Seidel, Matthias ; Sokolik, Renata ; Solanki, Kamal ; Stamenkovic, Bojana ; Stankovic, Aleksandra ; Stebbings, Simon ; Strauss, Gitte ; Sulli, Alberto ; Szamosi, Szilvia ; Szechinski, Jacek ; Szmyrka-Kaczmarek, Magdalena ; Szücs, Gabriella ; Tanaseanu, Cristina Mihaela ; Tiglea, Isabela ; Tyndall, Alan ; Ughi, Nicola ; Uprus, Maria ; Vacca, Alessandra ; Varju, Cecilia ; Venalis, Algirdas ; Venalis, Paulius ; Walker, Ulrich A. ; Widuchowska, Malgorzata ; Wiland, Piotr ; M. Wuttge, Dirk ; Zeni, Silvana ; Zenone, Thierry. / A comparison between nailfold capillaroscopy patterns in adulthood in juvenile and adult-onset systemic sclerosis : A EUSTAR exploratory study. In: Microvascular Research. 2015 ; Vol. 102. pp. 19-24.
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abstract = "Objective: Qualitative capillaroscopy patterns in juvenile- and adult-onset systemic sclerosis (SSc) were studied in adulthood using data from the EULAR Scleroderma Trials and Research (EUSTAR) database. Methods: Data collected between June 2004 and April 2013 were examined with focus on capillaroscopy. In this retrospective exploratory study, series of patients with juvenile-onset SSc were matched with series of adult-onset SSc having the same gender and autoantibody profile. Results: 30 of 123 patients with juvenile-onset and 2108 of 7133 with adult-onset SSc had data on capillaroscopy. Juvenile-onset SSc showed scleroderma pattern more frequently than adult-onset SSc (93.3{\%} and 88{\%}). The OR was 2.44 and 95{\%} CI 0.57-10.41. An active scleroderma pattern was present in 58{\%} of juvenile- and 61{\%} of adult-onset SSc. The OR was 0.91 and 95{\%} CI 0.28-2.93. The late scleroderma pattern was present in 61{\%} of juvenile- and 55.5{\%} of adult-onset SSc. The OR was 1.06 and 95{\%} CI 0.34-3.56. Conclusion: This is the first exploratory study on the comparison of capillaroscopy between juvenile- and adult-onset SSc in adulthood. Juvenile-onset SSc had an increase prevalence of scleroderma pattern, but a similar distribution of the three patterns was suggested. Further studies are needed to define this issue.",
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month = "11",
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language = "English",
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TY - JOUR

T1 - A comparison between nailfold capillaroscopy patterns in adulthood in juvenile and adult-onset systemic sclerosis

T2 - A EUSTAR exploratory study

AU - Ingegnoli, Francesca

AU - Boracchi, Patrizia

AU - Gualtierotti, Roberta

AU - Smith, Vanessa

AU - Cutolo, Maurizio

AU - Foeldvari, Ivan

AU - Airò, Paolo

AU - Alegre-Sancho, Juan Jose

AU - Allanore, Yannick

AU - Ananieva, Lidia P.

AU - Ancuta, Codrina

AU - Andrade, Luis Eduardo

AU - Aringer, Martin

AU - Becvar, Radim

AU - Bojinca, Mihai

AU - Butrimiene, Irena

AU - Cantatore, Francesco Paolo

AU - Caporali, Roberto

AU - Caramaschi, Paola

AU - Carreira, Patricia E.

AU - Chirieac, Rodica

AU - Corrado, Ada

AU - Cosentino, Vanesa

AU - Cuomo, Giovanna

AU - Czirjak, Laszlo

AU - Da Silva, José Antonio Pereira

AU - de la Peña Lefebvre, Paloma García

AU - De Keyser, Filip

AU - de Souza Müller, Carolina

AU - Damgaard, Kirsten

AU - Damjanov, Nemanja

AU - Denisov, Lev N.

AU - Distler, Oliver

AU - Doube, Alan

AU - Dumitrascu, Alina

AU - Engelhart, Merete

AU - Exposito, Marta Valero

AU - Eyerich, Kilian

AU - Farge-Bancel, Dominique

AU - Azevedo, Valderílio Feijó

AU - Foti, Rosario

AU - Frerix, Marc

AU - Gabrielli, Armando

AU - Garen, Torhild

AU - Gottschalk, Paola

AU - Groseanu, Laura

AU - Guiducci, Serena

AU - Günther, Claudia

AU - Hachulla, Eric

AU - Hein, Rüdiger

AU - Heitmann, Stefan

AU - Henes, Jörg

AU - Hesselstrand, Roger

AU - Highton, John

AU - Iannone, Florenzo

AU - Ionescu, Ruxandra Maria

AU - Kayser, Cristiane

AU - Karpec, Diana

AU - Kerzberg, Eduardo

AU - Kotulska, Anna

AU - Kopec-Medrek, Magdalena

AU - Kucharz, Eugene

AU - Krummel-Lorenz, Brigitte

AU - Lauffer, Felix

AU - Launay, David

AU - Li, Mengtao

AU - Litinsky, Ira

AU - Loyo, Esthela

AU - Cerinic, Marco Matucci

AU - Meroni, Pierluigi

AU - Midtvedt, Øyvind

AU - Mihai, Carmen Marina

AU - Montecucco, Carlomaurizio

AU - Montoya, Fabiana

AU - Morgiel, Ewa

AU - Mouthon, Luc

AU - Müller-Ladner, Ulf

AU - Nielsen, Henrik

AU - Opris, Daniela

AU - Ortiz-Santamaria, Vera

AU - Otsa, Kati

AU - Pileckyte, Margarita

AU - Pisarri, Simonetta

AU - Popescu, Monica

AU - Pozzi, Maria Rosa

AU - Puppo, Francesco

AU - Radominski, Sebastião Cezar

AU - Riccieri, Valeria

AU - Rosato, Edoardo

AU - Rozman, Blaz

AU - Rubio, Silvia Rodriguez

AU - Rugiene, Rita

AU - Saar, Petra

AU - Salvador, Maria João

AU - Seidel, Matthias

AU - Sokolik, Renata

AU - Solanki, Kamal

AU - Stamenkovic, Bojana

AU - Stankovic, Aleksandra

AU - Stebbings, Simon

AU - Strauss, Gitte

AU - Sulli, Alberto

AU - Szamosi, Szilvia

AU - Szechinski, Jacek

AU - Szmyrka-Kaczmarek, Magdalena

AU - Szücs, Gabriella

AU - Tanaseanu, Cristina Mihaela

AU - Tiglea, Isabela

AU - Tyndall, Alan

AU - Ughi, Nicola

AU - Uprus, Maria

AU - Vacca, Alessandra

AU - Varju, Cecilia

AU - Venalis, Algirdas

AU - Venalis, Paulius

AU - Walker, Ulrich A.

AU - Widuchowska, Malgorzata

AU - Wiland, Piotr

AU - M. Wuttge, Dirk

AU - Zeni, Silvana

AU - Zenone, Thierry

PY - 2015/11/1

Y1 - 2015/11/1

N2 - Objective: Qualitative capillaroscopy patterns in juvenile- and adult-onset systemic sclerosis (SSc) were studied in adulthood using data from the EULAR Scleroderma Trials and Research (EUSTAR) database. Methods: Data collected between June 2004 and April 2013 were examined with focus on capillaroscopy. In this retrospective exploratory study, series of patients with juvenile-onset SSc were matched with series of adult-onset SSc having the same gender and autoantibody profile. Results: 30 of 123 patients with juvenile-onset and 2108 of 7133 with adult-onset SSc had data on capillaroscopy. Juvenile-onset SSc showed scleroderma pattern more frequently than adult-onset SSc (93.3% and 88%). The OR was 2.44 and 95% CI 0.57-10.41. An active scleroderma pattern was present in 58% of juvenile- and 61% of adult-onset SSc. The OR was 0.91 and 95% CI 0.28-2.93. The late scleroderma pattern was present in 61% of juvenile- and 55.5% of adult-onset SSc. The OR was 1.06 and 95% CI 0.34-3.56. Conclusion: This is the first exploratory study on the comparison of capillaroscopy between juvenile- and adult-onset SSc in adulthood. Juvenile-onset SSc had an increase prevalence of scleroderma pattern, but a similar distribution of the three patterns was suggested. Further studies are needed to define this issue.

AB - Objective: Qualitative capillaroscopy patterns in juvenile- and adult-onset systemic sclerosis (SSc) were studied in adulthood using data from the EULAR Scleroderma Trials and Research (EUSTAR) database. Methods: Data collected between June 2004 and April 2013 were examined with focus on capillaroscopy. In this retrospective exploratory study, series of patients with juvenile-onset SSc were matched with series of adult-onset SSc having the same gender and autoantibody profile. Results: 30 of 123 patients with juvenile-onset and 2108 of 7133 with adult-onset SSc had data on capillaroscopy. Juvenile-onset SSc showed scleroderma pattern more frequently than adult-onset SSc (93.3% and 88%). The OR was 2.44 and 95% CI 0.57-10.41. An active scleroderma pattern was present in 58% of juvenile- and 61% of adult-onset SSc. The OR was 0.91 and 95% CI 0.28-2.93. The late scleroderma pattern was present in 61% of juvenile- and 55.5% of adult-onset SSc. The OR was 1.06 and 95% CI 0.34-3.56. Conclusion: This is the first exploratory study on the comparison of capillaroscopy between juvenile- and adult-onset SSc in adulthood. Juvenile-onset SSc had an increase prevalence of scleroderma pattern, but a similar distribution of the three patterns was suggested. Further studies are needed to define this issue.

KW - Capillaroscopy

KW - EUSTAR

KW - Juvenile systemic sclerosis

KW - Microcirculation

KW - Nailfold capillaroscopy

KW - Systemic sclerosis

KW - Videocapillaroscopy

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JF - Microvascular Research

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