A comparison between radiometric and fluorimetric methods for measuring SSAO activity

Alejandro Gella; Montse Solé; Irene Bolea; Mariacarla Ventriglia; Mariacristina Siotto; Nuria Durany; Rosanna Squitti; Mercedes Unzeta

doi:10.1007/s00702-013-0987-z

A comparison between radiometric and fluorimetric methods for measuring SSAO activity

Alejandro Gella, Montse Solé, Irene Bolea, Mariacarla Ventriglia, Mariacristina Siotto, Nuria Durany, Rosanna Squitti, Mercedes Unzeta

Fondazione Don Carlo Gnocchi Onlus

Research output: Contribution to journal › Article › peer-review

Abstract

Semicarbazide-sensitive amine oxidase (SSAO) metabolizes the oxidative deamination of primary aromatic and aliphatic amines. The final cytotoxic products of its catalysis contribute to diseases involving vascular degeneration. The increasing interest in measuring SSAO activity has led to the development of several different methods. Herein, we compare SSAO activity results obtained with radiometric and fluorimetric methods in 49 plasma samples. Although not interchangeable, a significant correlation was obtained between methods. Considering these limitations, the fluorimetric method might replace the radioisotopic one.

Original language	English
Pages (from-to)	1015-1018
Number of pages	4
Journal	Journal of Neural Transmission
Volume	120
Issue number	6
DOIs	https://doi.org/10.1007/s00702-013-0987-z
Publication status	Published - Jun 2013

Keywords

Biomarkers
Fluorimetric
Method comparison
Radiometric
Semicarbazide- sensitive amine oxidase

ASJC Scopus subject areas

Biological Psychiatry
Neurology
Clinical Neurology
Psychiatry and Mental health

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A comparison between radiometric and fluorimetric methods for measuring SSAO activity. / Gella, Alejandro; Solé, Montse; Bolea, Irene; Ventriglia, Mariacarla; Siotto, Mariacristina; Durany, Nuria; Squitti, Rosanna; Unzeta, Mercedes.

In: Journal of Neural Transmission, Vol. 120, No. 6, 06.2013, p. 1015-1018.

Research output: Contribution to journal › Article › peer-review

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AU - Durany, Nuria

AU - Squitti, Rosanna

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A comparison between radiometric and fluorimetric methods for measuring SSAO activity

Abstract

Keywords

ASJC Scopus subject areas

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