A comparison of cyclosporine, sulfasalazine, and symptomatic therapy in the treatment of psoriatic arthritis

C. Salvarani; P. Macchioni; I. Olivieri; A. Marchesoni; M. Cutolo; G. Ferraccioli; F. Cantini; F. Salaffi; A. Padula; C. Lovino; L. Dovigo; G. Bordin; C. Davoli; G. Pasero; O. D C Alberighi

A comparison of cyclosporine, sulfasalazine, and symptomatic therapy in the treatment of psoriatic arthritis

C. Salvarani, P. Macchioni, I. Olivieri, A. Marchesoni, M. Cutolo, G. Ferraccioli, F. Cantini, F. Salaffi, A. Padula, C. Lovino, L. Dovigo, G. Bordin, C. Davoli, G. Pasero, O. D C Alberighi

Arcispedale Santa Maria Nuova

Research output: Contribution to journal › Article › peer-review

Abstract

Objective. To compare the efficacy and tolerability of cyclosporine (CSA) with that of symptomatic therapy (ST) alone and sulfasalazine (SSZ) in the treatment of psoriatic arthritis (PsA). Methods. Twelve rheumatology centers recruited 99 patients with active PsA in a 24 week, prospective, randomized, open, controlled study. The patients were treated with CSA (3 mg/kg/day) or SSZ (2000 mg/day) plus ST, or ST alone (nonsteroidal antiinflammatory drugs, analgesics, and/or prednisone≤5 mg/day). The primary endpoint was the 6 month change in pain. Analyses were on the basis of the intention-to-treat principle. Results. In comparison with both SSZ and ST, there was a statistically significant difference in favor of CSA in terms of the mean changes in the pain score (p

Original language	English
Pages (from-to)	2274-2282
Number of pages	9
Journal	Journal of Rheumatology
Volume	28
Issue number	10
Publication status	Published - 2001

Keywords

Low dose cyclosporine
Psoriatic arthritis
Sulfasalazine
Symptomatic therapy

ASJC Scopus subject areas

Rheumatology
Immunology

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Salvarani, C., Macchioni, P., Olivieri, I., Marchesoni, A., Cutolo, M., Ferraccioli, G., Cantini, F., Salaffi, F., Padula, A., Lovino, C., Dovigo, L., Bordin, G., Davoli, C., Pasero, G., & Alberighi, O. D. C. (2001). A comparison of cyclosporine, sulfasalazine, and symptomatic therapy in the treatment of psoriatic arthritis. Journal of Rheumatology, 28(10), 2274-2282.

A comparison of cyclosporine, sulfasalazine, and symptomatic therapy in the treatment of psoriatic arthritis. / Salvarani, C.; Macchioni, P.; Olivieri, I.; Marchesoni, A.; Cutolo, M.; Ferraccioli, G.; Cantini, F.; Salaffi, F.; Padula, A.; Lovino, C.; Dovigo, L.; Bordin, G.; Davoli, C.; Pasero, G.; Alberighi, O. D C.

In: Journal of Rheumatology, Vol. 28, No. 10, 2001, p. 2274-2282.

Research output: Contribution to journal › Article › peer-review

Salvarani, C. ; Macchioni, P. ; Olivieri, I. ; Marchesoni, A. ; Cutolo, M. ; Ferraccioli, G. ; Cantini, F. ; Salaffi, F. ; Padula, A. ; Lovino, C. ; Dovigo, L. ; Bordin, G. ; Davoli, C. ; Pasero, G. ; Alberighi, O. D C. / A comparison of cyclosporine, sulfasalazine, and symptomatic therapy in the treatment of psoriatic arthritis. In: Journal of Rheumatology. 2001 ; Vol. 28, No. 10. pp. 2274-2282.

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AU - Olivieri, I.

AU - Marchesoni, A.

AU - Cutolo, M.

AU - Ferraccioli, G.

AU - Cantini, F.

AU - Salaffi, F.

AU - Padula, A.

AU - Lovino, C.

AU - Dovigo, L.

AU - Bordin, G.

AU - Davoli, C.

AU - Pasero, G.

AU - Alberighi, O. D C

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AB - Objective. To compare the efficacy and tolerability of cyclosporine (CSA) with that of symptomatic therapy (ST) alone and sulfasalazine (SSZ) in the treatment of psoriatic arthritis (PsA). Methods. Twelve rheumatology centers recruited 99 patients with active PsA in a 24 week, prospective, randomized, open, controlled study. The patients were treated with CSA (3 mg/kg/day) or SSZ (2000 mg/day) plus ST, or ST alone (nonsteroidal antiinflammatory drugs, analgesics, and/or prednisone≤5 mg/day). The primary endpoint was the 6 month change in pain. Analyses were on the basis of the intention-to-treat principle. Results. In comparison with both SSZ and ST, there was a statistically significant difference in favor of CSA in terms of the mean changes in the pain score (p

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