A comparison of different strategies used to invite subjects with a positive faecal occult blood test to a colonoscopy assessment. A randomised controlled trial in population-based screening programmes

Manuel Zorzi, Paolo Giorgi Rossi, Carla Cogo, Fabio Falcini, Daniela Giorgi, Grazia Grazzini, Loretta Mariotti, Vincenzo Matarese, Fabio Soppelsa, Carlo Senore, Antonio Ferro, Rosanna Mel, Anna Tison, Sabrina Di Camillo, Bastianello Germanà, Marco Bisello, Stefano Lazzaro, Luca Maria Antoniello, Sandra Bertazzo, Meris GennaroLucio Trevisani, Viviana Cifalà, Carolina Degl'Innocenti, Manola Migliori, Rosanna Ciacci, Americo Colamartini, Orietta Giuliani, Rosa Vattiato, Monica Palumbo, Alessandra Barca, Diego Baiocchi, Francesco Quadrino, Paola Bellardini, Alberto Picchi, Giovanni Finucci, Sergio Coccioli, Basilio Ubaldo Passamonti, Morena Malaspina, Beatrice Tintori, Valentina D'Angelo, Marco Silvani, Giorgia Fiorina, Arianna Capuano, Nereo Segnan

Research output: Contribution to journalArticle

Abstract

Objective: The purpose of this parallel randomised controlled trial was to compare compliance with different modalities used to invite patients with a positive immunochemical faecal occult blood test (FIT. +) for a total colonoscopy (TC). Method: FIT. + patients from nine Italian colorectal cancer screening programmes were randomised to be invited for a TC initially by mail or by phone and, for non-compliers, to be recalled by mail, for counselling with a general practitioner, or to meet with a specialist screening practitioner (nurse or healthcare assistant). Results: In all, 3777 patients were randomised to different invitation strategies. Compliance with an initial invitation by mail and by phone was similar (86.0% vs. 84.0%, relative risk - RR: 1.02; 95%CI 0.97-1.08). Among non-responders to the initial invitation, compliance with a recall by appointment with a specialist practitioner was 50.4%, significantly higher than with a mail recall (38.1%; RR:1.33; 95%CI 1.01-1.76) or with a face-to-face counselling with the GP (30.8%; RR:1.45;95%CI 1.14-1.87). Conclusion: Compliance with an initial invitation for a TC by mail and by phone was similar. A personal meeting with a specialist screening practitioner was associated with the highest compliance among non-compliers with initial invitations, while the involvement of GPs in this particular activity seemed less effective.

Original languageEnglish
Pages (from-to)70-76
Number of pages7
JournalPreventive Medicine
Volume65
DOIs
Publication statusPublished - 2014

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Occult Blood
Postal Service
Hematologic Tests
Colonoscopy
Randomized Controlled Trials
Population
Counseling
Allied Health Personnel
Nurse Practitioners
Early Detection of Cancer
General Practitioners
Compliance
Colorectal Neoplasms
Appointments and Schedules

Keywords

  • Colorectal cancer screening
  • Compliance with colonoscopy
  • Faecal occult blood test

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Epidemiology
  • Medicine(all)

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A comparison of different strategies used to invite subjects with a positive faecal occult blood test to a colonoscopy assessment. A randomised controlled trial in population-based screening programmes. / Zorzi, Manuel; Giorgi Rossi, Paolo; Cogo, Carla; Falcini, Fabio; Giorgi, Daniela; Grazzini, Grazia; Mariotti, Loretta; Matarese, Vincenzo; Soppelsa, Fabio; Senore, Carlo; Ferro, Antonio; Mel, Rosanna; Tison, Anna; Di Camillo, Sabrina; Germanà, Bastianello; Bisello, Marco; Lazzaro, Stefano; Antoniello, Luca Maria; Bertazzo, Sandra; Gennaro, Meris; Trevisani, Lucio; Cifalà, Viviana; Degl'Innocenti, Carolina; Migliori, Manola; Ciacci, Rosanna; Colamartini, Americo; Giuliani, Orietta; Vattiato, Rosa; Palumbo, Monica; Barca, Alessandra; Baiocchi, Diego; Quadrino, Francesco; Bellardini, Paola; Picchi, Alberto; Finucci, Giovanni; Coccioli, Sergio; Passamonti, Basilio Ubaldo; Malaspina, Morena; Tintori, Beatrice; D'Angelo, Valentina; Silvani, Marco; Fiorina, Giorgia; Capuano, Arianna; Segnan, Nereo.

In: Preventive Medicine, Vol. 65, 2014, p. 70-76.

Research output: Contribution to journalArticle

Zorzi, M, Giorgi Rossi, P, Cogo, C, Falcini, F, Giorgi, D, Grazzini, G, Mariotti, L, Matarese, V, Soppelsa, F, Senore, C, Ferro, A, Mel, R, Tison, A, Di Camillo, S, Germanà, B, Bisello, M, Lazzaro, S, Antoniello, LM, Bertazzo, S, Gennaro, M, Trevisani, L, Cifalà, V, Degl'Innocenti, C, Migliori, M, Ciacci, R, Colamartini, A, Giuliani, O, Vattiato, R, Palumbo, M, Barca, A, Baiocchi, D, Quadrino, F, Bellardini, P, Picchi, A, Finucci, G, Coccioli, S, Passamonti, BU, Malaspina, M, Tintori, B, D'Angelo, V, Silvani, M, Fiorina, G, Capuano, A & Segnan, N 2014, 'A comparison of different strategies used to invite subjects with a positive faecal occult blood test to a colonoscopy assessment. A randomised controlled trial in population-based screening programmes', Preventive Medicine, vol. 65, pp. 70-76. https://doi.org/10.1016/j.ypmed.2014.04.022
Zorzi, Manuel ; Giorgi Rossi, Paolo ; Cogo, Carla ; Falcini, Fabio ; Giorgi, Daniela ; Grazzini, Grazia ; Mariotti, Loretta ; Matarese, Vincenzo ; Soppelsa, Fabio ; Senore, Carlo ; Ferro, Antonio ; Mel, Rosanna ; Tison, Anna ; Di Camillo, Sabrina ; Germanà, Bastianello ; Bisello, Marco ; Lazzaro, Stefano ; Antoniello, Luca Maria ; Bertazzo, Sandra ; Gennaro, Meris ; Trevisani, Lucio ; Cifalà, Viviana ; Degl'Innocenti, Carolina ; Migliori, Manola ; Ciacci, Rosanna ; Colamartini, Americo ; Giuliani, Orietta ; Vattiato, Rosa ; Palumbo, Monica ; Barca, Alessandra ; Baiocchi, Diego ; Quadrino, Francesco ; Bellardini, Paola ; Picchi, Alberto ; Finucci, Giovanni ; Coccioli, Sergio ; Passamonti, Basilio Ubaldo ; Malaspina, Morena ; Tintori, Beatrice ; D'Angelo, Valentina ; Silvani, Marco ; Fiorina, Giorgia ; Capuano, Arianna ; Segnan, Nereo. / A comparison of different strategies used to invite subjects with a positive faecal occult blood test to a colonoscopy assessment. A randomised controlled trial in population-based screening programmes. In: Preventive Medicine. 2014 ; Vol. 65. pp. 70-76.
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abstract = "Objective: The purpose of this parallel randomised controlled trial was to compare compliance with different modalities used to invite patients with a positive immunochemical faecal occult blood test (FIT. +) for a total colonoscopy (TC). Method: FIT. + patients from nine Italian colorectal cancer screening programmes were randomised to be invited for a TC initially by mail or by phone and, for non-compliers, to be recalled by mail, for counselling with a general practitioner, or to meet with a specialist screening practitioner (nurse or healthcare assistant). Results: In all, 3777 patients were randomised to different invitation strategies. Compliance with an initial invitation by mail and by phone was similar (86.0{\%} vs. 84.0{\%}, relative risk - RR: 1.02; 95{\%}CI 0.97-1.08). Among non-responders to the initial invitation, compliance with a recall by appointment with a specialist practitioner was 50.4{\%}, significantly higher than with a mail recall (38.1{\%}; RR:1.33; 95{\%}CI 1.01-1.76) or with a face-to-face counselling with the GP (30.8{\%}; RR:1.45;95{\%}CI 1.14-1.87). Conclusion: Compliance with an initial invitation for a TC by mail and by phone was similar. A personal meeting with a specialist screening practitioner was associated with the highest compliance among non-compliers with initial invitations, while the involvement of GPs in this particular activity seemed less effective.",
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author = "Manuel Zorzi and {Giorgi Rossi}, Paolo and Carla Cogo and Fabio Falcini and Daniela Giorgi and Grazia Grazzini and Loretta Mariotti and Vincenzo Matarese and Fabio Soppelsa and Carlo Senore and Antonio Ferro and Rosanna Mel and Anna Tison and {Di Camillo}, Sabrina and Bastianello German{\`a} and Marco Bisello and Stefano Lazzaro and Antoniello, {Luca Maria} and Sandra Bertazzo and Meris Gennaro and Lucio Trevisani and Viviana Cifal{\`a} and Carolina Degl'Innocenti and Manola Migliori and Rosanna Ciacci and Americo Colamartini and Orietta Giuliani and Rosa Vattiato and Monica Palumbo and Alessandra Barca and Diego Baiocchi and Francesco Quadrino and Paola Bellardini and Alberto Picchi and Giovanni Finucci and Sergio Coccioli and Passamonti, {Basilio Ubaldo} and Morena Malaspina and Beatrice Tintori and Valentina D'Angelo and Marco Silvani and Giorgia Fiorina and Arianna Capuano and Nereo Segnan",
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T1 - A comparison of different strategies used to invite subjects with a positive faecal occult blood test to a colonoscopy assessment. A randomised controlled trial in population-based screening programmes

AU - Zorzi, Manuel

AU - Giorgi Rossi, Paolo

AU - Cogo, Carla

AU - Falcini, Fabio

AU - Giorgi, Daniela

AU - Grazzini, Grazia

AU - Mariotti, Loretta

AU - Matarese, Vincenzo

AU - Soppelsa, Fabio

AU - Senore, Carlo

AU - Ferro, Antonio

AU - Mel, Rosanna

AU - Tison, Anna

AU - Di Camillo, Sabrina

AU - Germanà, Bastianello

AU - Bisello, Marco

AU - Lazzaro, Stefano

AU - Antoniello, Luca Maria

AU - Bertazzo, Sandra

AU - Gennaro, Meris

AU - Trevisani, Lucio

AU - Cifalà, Viviana

AU - Degl'Innocenti, Carolina

AU - Migliori, Manola

AU - Ciacci, Rosanna

AU - Colamartini, Americo

AU - Giuliani, Orietta

AU - Vattiato, Rosa

AU - Palumbo, Monica

AU - Barca, Alessandra

AU - Baiocchi, Diego

AU - Quadrino, Francesco

AU - Bellardini, Paola

AU - Picchi, Alberto

AU - Finucci, Giovanni

AU - Coccioli, Sergio

AU - Passamonti, Basilio Ubaldo

AU - Malaspina, Morena

AU - Tintori, Beatrice

AU - D'Angelo, Valentina

AU - Silvani, Marco

AU - Fiorina, Giorgia

AU - Capuano, Arianna

AU - Segnan, Nereo

PY - 2014

Y1 - 2014

N2 - Objective: The purpose of this parallel randomised controlled trial was to compare compliance with different modalities used to invite patients with a positive immunochemical faecal occult blood test (FIT. +) for a total colonoscopy (TC). Method: FIT. + patients from nine Italian colorectal cancer screening programmes were randomised to be invited for a TC initially by mail or by phone and, for non-compliers, to be recalled by mail, for counselling with a general practitioner, or to meet with a specialist screening practitioner (nurse or healthcare assistant). Results: In all, 3777 patients were randomised to different invitation strategies. Compliance with an initial invitation by mail and by phone was similar (86.0% vs. 84.0%, relative risk - RR: 1.02; 95%CI 0.97-1.08). Among non-responders to the initial invitation, compliance with a recall by appointment with a specialist practitioner was 50.4%, significantly higher than with a mail recall (38.1%; RR:1.33; 95%CI 1.01-1.76) or with a face-to-face counselling with the GP (30.8%; RR:1.45;95%CI 1.14-1.87). Conclusion: Compliance with an initial invitation for a TC by mail and by phone was similar. A personal meeting with a specialist screening practitioner was associated with the highest compliance among non-compliers with initial invitations, while the involvement of GPs in this particular activity seemed less effective.

AB - Objective: The purpose of this parallel randomised controlled trial was to compare compliance with different modalities used to invite patients with a positive immunochemical faecal occult blood test (FIT. +) for a total colonoscopy (TC). Method: FIT. + patients from nine Italian colorectal cancer screening programmes were randomised to be invited for a TC initially by mail or by phone and, for non-compliers, to be recalled by mail, for counselling with a general practitioner, or to meet with a specialist screening practitioner (nurse or healthcare assistant). Results: In all, 3777 patients were randomised to different invitation strategies. Compliance with an initial invitation by mail and by phone was similar (86.0% vs. 84.0%, relative risk - RR: 1.02; 95%CI 0.97-1.08). Among non-responders to the initial invitation, compliance with a recall by appointment with a specialist practitioner was 50.4%, significantly higher than with a mail recall (38.1%; RR:1.33; 95%CI 1.01-1.76) or with a face-to-face counselling with the GP (30.8%; RR:1.45;95%CI 1.14-1.87). Conclusion: Compliance with an initial invitation for a TC by mail and by phone was similar. A personal meeting with a specialist screening practitioner was associated with the highest compliance among non-compliers with initial invitations, while the involvement of GPs in this particular activity seemed less effective.

KW - Colorectal cancer screening

KW - Compliance with colonoscopy

KW - Faecal occult blood test

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