A comparison of linear and orthogonal regression analysis for local INR determination in ECAA coagulometer studies

L. Poller, A. M H P Van Den Besselaar, J. Jespersen, A. Tripodi, D. Houghton

Research output: Contribution to journalArticlepeer-review

Abstract

International sensitivity index calibrations based on the W.H.O. recommended method depend on orthogonal regression analysis. As this is not readily available in statistical packages, comparison has been made with simple linear regression analysis in a study of coagulometer effects on the International Normalized Ratio (INR) at 155 European centres. Sets of seven lyophilized normal and 20 lyophilized artificially depleted abnormal plasmas were provided with five coumarin test plasmas and two European Concerted Action on Anticoagulation reference thromboplastins (low International Sensitivity Index (ISI) human and high ISI rabbit). Local ISI based on the artificially depleted lyophilized plasmas using conventional orthogonal regression gave good correction for local coagulometer effects on the human reagent and minimal correction with the rabbit reagent INR. Results were considerably worse after attempts at correction using calibration based on linear regression analysis with both reagents. The results indicate that calibration of coagulometer prothrombin time systems using simple linear regression is not appropriate.

Original languageEnglish
Pages (from-to)910-917
Number of pages8
JournalBritish Journal of Haematology
Volume102
Issue number4
DOIs
Publication statusPublished - 1998

Keywords

  • Coagulometers
  • INR
  • Linear
  • Orthogonal
  • Regression

ASJC Scopus subject areas

  • Hematology

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