A comparison of methods of loco-regional chemotherapy combined with systemic chemotherapy as neo-adjuvant treatment of osteosarcoma of the extremity

G. Bacci, S. Ferrari, A. Tienghi, F. Bertoni, M. Mercuri, A. Longhi, G. Fiorentini, C. Forni, P. Bacchini, S. Rimondini, U. De Giorgi, P. Picci

Research output: Contribution to journalArticlepeer-review

Abstract

Aim: Our experience of pre-operative intraarterial (i.a.) vs intravenous (i.v.) infusion of cisplatinum (CDP) in a multiagent neo-adjuvant chemotherapy for osteosarcoma of the extremity is reported. Methods: Two successive randomized studies were performed. In the first, pre-operatively, CDP i.a. vs CDP i.v. was applied in combination with high-dose methotrexate (HDMTX) and adriamycin (ADM) within a three-drug regimen. In the second, a combination of HDMTX, ADM and IFO, within a four-drug regimen was tested. Results: The rate of responses to chemotherapy (tumour necrosis ≥ 90%) was significantly higher (P

Original languageEnglish
Pages (from-to)98-104
Number of pages7
JournalEuropean Journal of Surgical Oncology
Volume27
Issue number1
DOIs
Publication statusPublished - 2001

Keywords

  • Cisplatin
  • Intra
  • Neo-adjuvant chemotherapy
  • Osteosarcoma

ASJC Scopus subject areas

  • Oncology
  • Surgery

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