A comparison of patients with hepatitis B- or hepatitis C-based advanced-stage hepatocellular carcinoma

Brian I. Carr, Vito Guerra, Jennifer L. Steel, Sheng Nan Lu

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Hepatocellular carcinoma (HCC) is a leading cause of cancer death and has characteristic causes, epidemiology and clinical features. The leading causes include hepatitis B virus (HBV), hepatitis C virus (HCV), alcoholism, and aflatoxin B1 dietary exposure, as well as combinations of these factors. Few cancers offer the opportunity to study the clinical and cancer phenotype that results from different causes, quite like HCC. Advantage was taken of a large cohort of advanced, unresectable and untransplantable HCCs to compare the phenotypes resulting from HBV-based compared with HCV-based HCC. The main findings were that HBV-based HCC patients were statistically significantly younger, had a higher percent of males, had larger maximum tumor sizes, and had higher blood alpha-fetoprotein (AFP) and albumin levels and platelet counts than HCV-based HCC patients. These differences partly reflect an earlier age of HBV infection and a lesser degree of cirrhosis-associated liver damage, as a result of the different biological consequences of chronic HBV compared with chronic HCV infection.

Original languageEnglish
Pages (from-to)309-315
Number of pages7
JournalSeminars in Oncology
Volume42
Issue number2
DOIs
Publication statusPublished - Apr 1 2015

Fingerprint

Hepatitis C
Hepatitis B
Hepatitis B virus
Hepatocellular Carcinoma
Hepacivirus
Virus Diseases
Neoplasms
Phenotype
Aflatoxin B1
Chronic Hepatitis B
alpha-Fetoproteins
Chronic Hepatitis C
Platelet Count
Liver Cirrhosis
Alcoholism
Cause of Death
Epidemiology

ASJC Scopus subject areas

  • Oncology
  • Hematology
  • Medicine(all)

Cite this

A comparison of patients with hepatitis B- or hepatitis C-based advanced-stage hepatocellular carcinoma. / Carr, Brian I.; Guerra, Vito; Steel, Jennifer L.; Lu, Sheng Nan.

In: Seminars in Oncology, Vol. 42, No. 2, 01.04.2015, p. 309-315.

Research output: Contribution to journalArticle

Carr, Brian I. ; Guerra, Vito ; Steel, Jennifer L. ; Lu, Sheng Nan. / A comparison of patients with hepatitis B- or hepatitis C-based advanced-stage hepatocellular carcinoma. In: Seminars in Oncology. 2015 ; Vol. 42, No. 2. pp. 309-315.
@article{726f4d2e058648b590590a84e67da2f3,
title = "A comparison of patients with hepatitis B- or hepatitis C-based advanced-stage hepatocellular carcinoma",
abstract = "Hepatocellular carcinoma (HCC) is a leading cause of cancer death and has characteristic causes, epidemiology and clinical features. The leading causes include hepatitis B virus (HBV), hepatitis C virus (HCV), alcoholism, and aflatoxin B1 dietary exposure, as well as combinations of these factors. Few cancers offer the opportunity to study the clinical and cancer phenotype that results from different causes, quite like HCC. Advantage was taken of a large cohort of advanced, unresectable and untransplantable HCCs to compare the phenotypes resulting from HBV-based compared with HCV-based HCC. The main findings were that HBV-based HCC patients were statistically significantly younger, had a higher percent of males, had larger maximum tumor sizes, and had higher blood alpha-fetoprotein (AFP) and albumin levels and platelet counts than HCV-based HCC patients. These differences partly reflect an earlier age of HBV infection and a lesser degree of cirrhosis-associated liver damage, as a result of the different biological consequences of chronic HBV compared with chronic HCV infection.",
author = "Carr, {Brian I.} and Vito Guerra and Steel, {Jennifer L.} and Lu, {Sheng Nan}",
year = "2015",
month = "4",
day = "1",
doi = "10.1053/j.seminoncol.2014.12.019",
language = "English",
volume = "42",
pages = "309--315",
journal = "Seminars in Oncology",
issn = "0093-7754",
publisher = "W.B. Saunders Ltd",
number = "2",

}

TY - JOUR

T1 - A comparison of patients with hepatitis B- or hepatitis C-based advanced-stage hepatocellular carcinoma

AU - Carr, Brian I.

AU - Guerra, Vito

AU - Steel, Jennifer L.

AU - Lu, Sheng Nan

PY - 2015/4/1

Y1 - 2015/4/1

N2 - Hepatocellular carcinoma (HCC) is a leading cause of cancer death and has characteristic causes, epidemiology and clinical features. The leading causes include hepatitis B virus (HBV), hepatitis C virus (HCV), alcoholism, and aflatoxin B1 dietary exposure, as well as combinations of these factors. Few cancers offer the opportunity to study the clinical and cancer phenotype that results from different causes, quite like HCC. Advantage was taken of a large cohort of advanced, unresectable and untransplantable HCCs to compare the phenotypes resulting from HBV-based compared with HCV-based HCC. The main findings were that HBV-based HCC patients were statistically significantly younger, had a higher percent of males, had larger maximum tumor sizes, and had higher blood alpha-fetoprotein (AFP) and albumin levels and platelet counts than HCV-based HCC patients. These differences partly reflect an earlier age of HBV infection and a lesser degree of cirrhosis-associated liver damage, as a result of the different biological consequences of chronic HBV compared with chronic HCV infection.

AB - Hepatocellular carcinoma (HCC) is a leading cause of cancer death and has characteristic causes, epidemiology and clinical features. The leading causes include hepatitis B virus (HBV), hepatitis C virus (HCV), alcoholism, and aflatoxin B1 dietary exposure, as well as combinations of these factors. Few cancers offer the opportunity to study the clinical and cancer phenotype that results from different causes, quite like HCC. Advantage was taken of a large cohort of advanced, unresectable and untransplantable HCCs to compare the phenotypes resulting from HBV-based compared with HCV-based HCC. The main findings were that HBV-based HCC patients were statistically significantly younger, had a higher percent of males, had larger maximum tumor sizes, and had higher blood alpha-fetoprotein (AFP) and albumin levels and platelet counts than HCV-based HCC patients. These differences partly reflect an earlier age of HBV infection and a lesser degree of cirrhosis-associated liver damage, as a result of the different biological consequences of chronic HBV compared with chronic HCV infection.

UR - http://www.scopus.com/inward/record.url?scp=84926285208&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84926285208&partnerID=8YFLogxK

U2 - 10.1053/j.seminoncol.2014.12.019

DO - 10.1053/j.seminoncol.2014.12.019

M3 - Article

C2 - 25843735

AN - SCOPUS:84926285208

VL - 42

SP - 309

EP - 315

JO - Seminars in Oncology

JF - Seminars in Oncology

SN - 0093-7754

IS - 2

ER -