A Comparison of the Conditioning Regimens BEAM and FEAM for Autologous Hematopoietic Stem Cell Transplantation in Lymphoma: An Observational Study on 1038 Patients From Fondazione Italiana Linfomi

Fondazione Italiana Linfomi Postgraduate Master Course, Jacopo Olivieri, Federico Mosna, Matteo Pelosini, Angelo Fama, Sara Rattotti, Margherita Giannoccaro, Giuseppe Carli, Maria Chiara Tisi, Simone Ferrero, Nicola Sgherza, Anna Maria Mazzone, Dario Marino, Teresa Calimeri, Giacomo Loseto, Francesco Saraceni, Gabriella Tomei, Simona Sica, Giulia Perali, Katia CodeluppiAtto Billio, Attilio Olivieri, Enrico Orciuolo, Rossella Matera, Piero Maria Stefani, Carlo Borghero, Paola Ghione, Nicola Cascavilla, Francesco Lanza, Patrizia Chiusolo, Silvia Finotto, Irene Federici, Filippo Gherlinzoni, Riccardo Centurioni, Renato Fanin, Francesco Zaja

Research output: Contribution to journalArticle

Abstract

BEAM (carmustine [bis-chloroethylnitrosourea (BCNU)]-etoposide-cytarabine-melphalan) chemotherapy is the standard conditioning regimen for autologous stem cell transplantation (ASCT) in lymphomas. Owing to BCNU shortages, many centers switched to fotemustine-substituted BEAM (FEAM), lacking proof of equivalence. We conducted a retrospective cohort study in 18 Italian centers to compare the safety and efficacy of BEAM and FEAM regimens for ASCT in lymphomas performed from 2008 to 2015. We enrolled 1038 patients (BEAM = 607, FEAM = 431), of which 27% had Hodgkin lymphoma (HL), 14% indolent non-Hodgkin lymphoma (NHL), and 59% aggressive NHL. Baseline characteristics including age, sex, stage, B-symptoms, extranodal involvement, previous treatments, response before ASCT, and overall conditioning intensity were well balanced between BEAM and FEAM; notable exceptions were median ASCT year (BEAM = 2011 versus FEAM = 2013, P 
Original languageEnglish
Pages (from-to)1814-1822
Number of pages9
JournalBiology of Blood and Marrow Transplantation
Volume24
Issue number9
DOIs
Publication statusPublished - Sep 1 2018

    Fingerprint

Cite this