Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 1814-1822 |
| Number of pages | 9 |
| Journal | Biology of Blood and Marrow Transplantation |
| Volume | 24 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - Sep 1 2018 |
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A Comparison of the Conditioning Regimens BEAM and FEAM for Autologous Hematopoietic Stem Cell Transplantation in Lymphoma: An Observational Study on 1038 Patients From Fondazione Italiana Linfomi. / Course, Fondazione Italiana Linfomi Postgraduate Master; Olivieri, Jacopo; Mosna, Federico; Pelosini, Matteo; Fama, Angelo; Rattotti, Sara; Giannoccaro, Margherita; Carli, Giuseppe; Tisi, Maria Chiara; Ferrero, Simone; Sgherza, Nicola; Mazzone, Anna Maria; Marino, Dario; Calimeri, Teresa; Loseto, Giacomo; Saraceni, Francesco; Tomei, Gabriella; Sica, Simona; Perali, Giulia; Codeluppi, Katia; Billio, Atto; Olivieri, Attilio; Orciuolo, Enrico; Matera, Rossella; Stefani, Piero Maria; Borghero, Carlo; Ghione, Paola; Cascavilla, Nicola; Lanza, Francesco; Chiusolo, Patrizia; Finotto, Silvia; Federici, Irene; Gherlinzoni, Filippo; Centurioni, Riccardo; Fanin, Renato; Zaja, Francesco.
In: Biology of Blood and Marrow Transplantation, Vol. 24, No. 9, 01.09.2018, p. 1814-1822.Research output: Contribution to journal › Article
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TY - JOUR
T1 - A Comparison of the Conditioning Regimens BEAM and FEAM for Autologous Hematopoietic Stem Cell Transplantation in Lymphoma: An Observational Study on 1038 Patients From Fondazione Italiana Linfomi
AU - Course, Fondazione Italiana Linfomi Postgraduate Master
AU - Olivieri, Jacopo
AU - Mosna, Federico
AU - Pelosini, Matteo
AU - Fama, Angelo
AU - Rattotti, Sara
AU - Giannoccaro, Margherita
AU - Carli, Giuseppe
AU - Tisi, Maria Chiara
AU - Ferrero, Simone
AU - Sgherza, Nicola
AU - Mazzone, Anna Maria
AU - Marino, Dario
AU - Calimeri, Teresa
AU - Loseto, Giacomo
AU - Saraceni, Francesco
AU - Tomei, Gabriella
AU - Sica, Simona
AU - Perali, Giulia
AU - Codeluppi, Katia
AU - Billio, Atto
AU - Olivieri, Attilio
AU - Orciuolo, Enrico
AU - Matera, Rossella
AU - Stefani, Piero Maria
AU - Borghero, Carlo
AU - Ghione, Paola
AU - Cascavilla, Nicola
AU - Lanza, Francesco
AU - Chiusolo, Patrizia
AU - Finotto, Silvia
AU - Federici, Irene
AU - Gherlinzoni, Filippo
AU - Centurioni, Riccardo
AU - Fanin, Renato
AU - Zaja, Francesco
N1 - Copyright © 2018 The American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.
PY - 2018/9/1
Y1 - 2018/9/1
N2 - BEAM (carmustine [bis-chloroethylnitrosourea (BCNU)]-etoposide-cytarabine-melphalan) chemotherapy is the standard conditioning regimen for autologous stem cell transplantation (ASCT) in lymphomas. Owing to BCNU shortages, many centers switched to fotemustine-substituted BEAM (FEAM), lacking proof of equivalence. We conducted a retrospective cohort study in 18 Italian centers to compare the safety and efficacy of BEAM and FEAM regimens for ASCT in lymphomas performed from 2008 to 2015. We enrolled 1038 patients (BEAM = 607, FEAM = 431), of which 27% had Hodgkin lymphoma (HL), 14% indolent non-Hodgkin lymphoma (NHL), and 59% aggressive NHL. Baseline characteristics including age, sex, stage, B-symptoms, extranodal involvement, previous treatments, response before ASCT, and overall conditioning intensity were well balanced between BEAM and FEAM; notable exceptions were median ASCT year (BEAM = 2011 versus FEAM = 2013, P
AB - BEAM (carmustine [bis-chloroethylnitrosourea (BCNU)]-etoposide-cytarabine-melphalan) chemotherapy is the standard conditioning regimen for autologous stem cell transplantation (ASCT) in lymphomas. Owing to BCNU shortages, many centers switched to fotemustine-substituted BEAM (FEAM), lacking proof of equivalence. We conducted a retrospective cohort study in 18 Italian centers to compare the safety and efficacy of BEAM and FEAM regimens for ASCT in lymphomas performed from 2008 to 2015. We enrolled 1038 patients (BEAM = 607, FEAM = 431), of which 27% had Hodgkin lymphoma (HL), 14% indolent non-Hodgkin lymphoma (NHL), and 59% aggressive NHL. Baseline characteristics including age, sex, stage, B-symptoms, extranodal involvement, previous treatments, response before ASCT, and overall conditioning intensity were well balanced between BEAM and FEAM; notable exceptions were median ASCT year (BEAM = 2011 versus FEAM = 2013, P
U2 - 10.1016/j.bbmt.2018.05.018
DO - 10.1016/j.bbmt.2018.05.018
M3 - Article
VL - 24
SP - 1814
EP - 1822
JO - Biology of Blood and Marrow Transplantation
JF - Biology of Blood and Marrow Transplantation
SN - 1083-8791
IS - 9
ER -