A comparison of the magnetization transfer ratios of MS lesions enhancing after the injection of a standard or a triple dose of gadolinium-DTPA

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Abstract

Brain magnetic resonance imaging (MRI) obtained after the injection of a triple dose (TD) ofgadolinium-DTPA (Gd) detects about 70% more enhancing lesions than MRI obtained after the injection of a standard dose (SD) in patients with multiple sclerosis (MS). No study has evaluated the intrinsic characteristics of lesions enhancing only after TD injection. Magnetization transfer imaging (MTl) provides in vivo information about the pathological characteristics of MS lesions. In this study we performed MTI studies to evaluate whether lesions which enhance only after TD have different intrinsic characteristics compared to those which enhance after SD injection. Four monthly MRI scans were obtained in ten patients with either relapsing-remitting or secondary progressive MS. At each time point, two enhanced Tl-we.ighted scans, separated by an interval of 24 hours, were obtained 5 to 7 minutes after the injection of a SD (0.1 mmol/kg) and a TD (0.3 mmol/kg) of Gd. Before the SD injection, a magnetization transfer imaging (MTI), a dual echo and aTl-weighted scans were also obtained At each time point, a single cbserver, unaware of the Gd dose used, identified enhancing lesions. The MT ratio (MTR) of each enhancing lesions was then measured. During the three month follow up, a total of 102 lesions enhanced after SD injection and 72 only after TD injection. The mean MTR was 31.4% (standard deviation=8.1%) for lesions enhancing after SD injection and 37.6% (standard deviation=5.7%) for lesions enhancing only after TD injection (D

Original languageEnglish
Pages (from-to)137
Number of pages1
JournalItalian Journal of Neurological Sciences
Volume18
Issue number4
Publication statusPublished - 1997

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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