TY - JOUR
T1 - A complex karyotype including a t(2;11) in a paediatric ependymoma
T2 - Case report and review of the literature
AU - Aschero, Simona
AU - Vallero, Stefano
AU - Morra, Isabella
AU - Impera, Luciana
AU - Forni, Marco
AU - Sandri, Alessandro
AU - Basso, Maria E.
AU - Storlazzi, Clelia T.
AU - Giordano, Flavio
AU - Fidani, Paola
AU - De Ioris, Maria A.
AU - Di Montezemolo, Luca Cordero
PY - 2010/8
Y1 - 2010/8
N2 - Ependymomas are glial tumours representing approximately 5-10% of all intracranial tumours and are the third most common primary brain tumour in childhood. Only a few karyotypic studies on paediatric ependymomas have been published and no specific chromosomal aberration has been specifically related to this type of cancer. We performed cytogenetic analysis of an ependymoma in an 11-year-old boy. Our patient showed a complex karyotype, characterized by a near-tetraploidy and a sole structural unbalanced aberration: der(2)t(2;11)(q11.2;q13.1), which has not been described before. We here discuss such cytogenetic findings, comparing our data with those reported in the literature.
AB - Ependymomas are glial tumours representing approximately 5-10% of all intracranial tumours and are the third most common primary brain tumour in childhood. Only a few karyotypic studies on paediatric ependymomas have been published and no specific chromosomal aberration has been specifically related to this type of cancer. We performed cytogenetic analysis of an ependymoma in an 11-year-old boy. Our patient showed a complex karyotype, characterized by a near-tetraploidy and a sole structural unbalanced aberration: der(2)t(2;11)(q11.2;q13.1), which has not been described before. We here discuss such cytogenetic findings, comparing our data with those reported in the literature.
KW - Anaplastic ependymoma
KW - Childhood
KW - Cytogenetics
KW - Multicolour-FISH
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U2 - 10.1007/s11060-009-0108-x
DO - 10.1007/s11060-009-0108-x
M3 - Article
C2 - 20066474
AN - SCOPUS:77954424117
VL - 99
SP - 141
EP - 146
JO - Journal of Neuro-Oncology
JF - Journal of Neuro-Oncology
SN - 0167-594X
IS - 1
ER -