A complex karyotype including a t(2;11) in a paediatric ependymoma: Case report and review of the literature

Simona Aschero; Stefano Vallero; Isabella Morra; Luciana Impera; Marco Forni; Alessandro Sandri; Maria E. Basso; Clelia T. Storlazzi; Flavio Giordano; Paola Fidani; Maria A. De Ioris; Luca Cordero Di Montezemolo

doi:10.1007/s11060-009-0108-x

A complex karyotype including a t(2;11) in a paediatric ependymoma: Case report and review of the literature

Simona Aschero, Stefano Vallero, Isabella Morra, Luciana Impera, Marco Forni, Alessandro Sandri, Maria E. Basso, Clelia T. Storlazzi, Flavio Giordano, Paola Fidani, Maria A. De Ioris, Luca Cordero Di Montezemolo

Ospedale Pediatrico Bambino Gesu

Research output: Contribution to journal › Article › peer-review

Abstract

Ependymomas are glial tumours representing approximately 5-10% of all intracranial tumours and are the third most common primary brain tumour in childhood. Only a few karyotypic studies on paediatric ependymomas have been published and no specific chromosomal aberration has been specifically related to this type of cancer. We performed cytogenetic analysis of an ependymoma in an 11-year-old boy. Our patient showed a complex karyotype, characterized by a near-tetraploidy and a sole structural unbalanced aberration: der(2)t(2;11)(q11.2;q13.1), which has not been described before. We here discuss such cytogenetic findings, comparing our data with those reported in the literature.

Original language	English
Pages (from-to)	141-146
Number of pages	6
Journal	Journal of Neuro-Oncology
Volume	99
Issue number	1
DOIs	https://doi.org/10.1007/s11060-009-0108-x
Publication status	Published - Aug 2010

Keywords

Anaplastic ependymoma
Childhood
Cytogenetics
Multicolour-FISH

ASJC Scopus subject areas

Clinical Neurology
Cancer Research
Oncology
Neurology
Medicine(all)

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Aschero, S., Vallero, S., Morra, I., Impera, L., Forni, M., Sandri, A., Basso, M. E., Storlazzi, C. T., Giordano, F., Fidani, P., De Ioris, M. A., & Di Montezemolo, L. C. (2010). A complex karyotype including a t(2;11) in a paediatric ependymoma: Case report and review of the literature. Journal of Neuro-Oncology, 99(1), 141-146. https://doi.org/10.1007/s11060-009-0108-x

A complex karyotype including a t(2;11) in a paediatric ependymoma : Case report and review of the literature. / Aschero, Simona; Vallero, Stefano; Morra, Isabella; Impera, Luciana; Forni, Marco; Sandri, Alessandro; Basso, Maria E.; Storlazzi, Clelia T.; Giordano, Flavio; Fidani, Paola; De Ioris, Maria A.; Di Montezemolo, Luca Cordero.

In: Journal of Neuro-Oncology, Vol. 99, No. 1, 08.2010, p. 141-146.

Research output: Contribution to journal › Article › peer-review

Aschero, Simona ; Vallero, Stefano ; Morra, Isabella ; Impera, Luciana ; Forni, Marco ; Sandri, Alessandro ; Basso, Maria E. ; Storlazzi, Clelia T. ; Giordano, Flavio ; Fidani, Paola ; De Ioris, Maria A. ; Di Montezemolo, Luca Cordero. / A complex karyotype including a t(2;11) in a paediatric ependymoma : Case report and review of the literature. In: Journal of Neuro-Oncology. 2010 ; Vol. 99, No. 1. pp. 141-146.

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