A complex karyotype including a t(2;11) in a paediatric ependymoma: Case report and review of the literature

Simona Aschero, Stefano Vallero, Isabella Morra, Luciana Impera, Marco Forni, Alessandro Sandri, Maria E. Basso, Clelia T. Storlazzi, Flavio Giordano, Paola Fidani, Maria A. De Ioris, Luca Cordero Di Montezemolo

Research output: Contribution to journalArticlepeer-review

Abstract

Ependymomas are glial tumours representing approximately 5-10% of all intracranial tumours and are the third most common primary brain tumour in childhood. Only a few karyotypic studies on paediatric ependymomas have been published and no specific chromosomal aberration has been specifically related to this type of cancer. We performed cytogenetic analysis of an ependymoma in an 11-year-old boy. Our patient showed a complex karyotype, characterized by a near-tetraploidy and a sole structural unbalanced aberration: der(2)t(2;11)(q11.2;q13.1), which has not been described before. We here discuss such cytogenetic findings, comparing our data with those reported in the literature.

Original languageEnglish
Pages (from-to)141-146
Number of pages6
JournalJournal of Neuro-Oncology
Volume99
Issue number1
DOIs
Publication statusPublished - Aug 2010

Keywords

  • Anaplastic ependymoma
  • Childhood
  • Cytogenetics
  • Multicolour-FISH

ASJC Scopus subject areas

  • Clinical Neurology
  • Cancer Research
  • Oncology
  • Neurology
  • Medicine(all)

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