A complex relation between depression and multiple sclerosis: a descriptive review

Francesco Corallo, Viviana Lo Buono, Roberto Genovese, Rosanna Palmeri, Marcella Di Cara, Carmela Rifici, Edoardo Sessa, Giangaetano D’Aleo, Francesco Galletti, Lilla Bonanno, Silvia Marino

Research output: Contribution to journalReview articlepeer-review


Background: Multiple sclerosis (MS) is a demyelinating neurodegenerative disease that affects central nervous system (CNS). MS patients are more likely to develop depressive symptoms than patients with other chronic diseases. Objective: In this review, we have analysed if there is a correlation between brain lesions (BL), structural damage (SD) and depressive symptoms (DS). Methods: We Searched on PubMed and Web of Science databases and screening references of included studied and some review article for additional citations. From initial 745 studies, only 9 met the inclusion criteria. All studies conducted research on 389 patients with MS associated with DS and 120 HC (healthy controls). Results: The selected researches highlighted the involvement of limbic system, the role of hippocampus and the impact of brain lesions on the emotional status of MS patients. Discussion: In the genesis of depression are implicated many mechanisms including genetic, biochemical, immunological and psychosocial factors, even if a prominent role in the onset of DS seem to be associated with structural and functional brain alterations.

Original languageEnglish
Pages (from-to)1551-1558
Number of pages8
JournalNeurological Sciences
Issue number8
Publication statusPublished - Aug 1 2019


  • Anatomical–functional abnormalities
  • Depressive symptoms
  • Hippocampus
  • Magnetic resonance
  • Multiple sclerosis
  • Organic lesions

ASJC Scopus subject areas

  • Dermatology
  • Clinical Neurology
  • Psychiatry and Mental health


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