A complex translocation (5;7) in a patient with acute nonlymphocytic leukemia evolved from a myelodysplastic syndrome

P. Bernasconi, P. M. Cavigliano, E. Genini, C. Castagnola, L. Malcovati, S. Calatroni, M. Caresana, M. Boni, E. P. Alessandrino, C. Astori, A. Corso, C. Bernasconi

Research output: Contribution to journalArticle

Abstract

Complete or partial monosomy for the long arms of chromosomes 5 or 7 or both is frequently observed in therapy-related myelodysplostic syndromes and acute nonlymphocytic leukemia. Sporadic cases have been reported in which partial monosomy is due to unbalanced translocations. The patient described herein carries one such rearrangement, 46,XY,t(1;2)(q32;p23),del(5)(q13),der(7)(5qter→ 5q22::7p15→7q21:),del(12)(p12), resulting in partial monosomy for the long arms of chromosomes 5 and 7 and in partial monosomy for the short arm of chromosome 7.

Original languageEnglish
Pages (from-to)182-186
Number of pages5
JournalCancer Genetics and Cytogenetics
Volume105
Issue number2
DOIs
Publication statusPublished - Sep 1998

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ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

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