A complex translocation (5;7) in a patient with acute nonlymphocytic leukemia evolved from a myelodysplastic syndrome

P. Bernasconi, P. M. Cavigliano, E. Genini, C. Castagnola, L. Malcovati, S. Calatroni, M. Caresana, M. Boni, E. P. Alessandrino, C. Astori, A. Corso, C. Bernasconi

Research output: Contribution to journalArticle

Abstract

Complete or partial monosomy for the long arms of chromosomes 5 or 7 or both is frequently observed in therapy-related myelodysplostic syndromes and acute nonlymphocytic leukemia. Sporadic cases have been reported in which partial monosomy is due to unbalanced translocations. The patient described herein carries one such rearrangement, 46,XY,t(1;2)(q32;p23),del(5)(q13),der(7)(5qter→ 5q22::7p15→7q21:),del(12)(p12), resulting in partial monosomy for the long arms of chromosomes 5 and 7 and in partial monosomy for the short arm of chromosome 7.

Original languageEnglish
Pages (from-to)182-186
Number of pages5
JournalCancer Genetics and Cytogenetics
Volume105
Issue number2
DOIs
Publication statusPublished - Sep 1998

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Chromosome Deletion
Myelodysplastic Syndromes
Acute Myeloid Leukemia
Chromosomes, Human, Pair 7
Chromosomes, Human, Pair 5
Therapeutics

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

A complex translocation (5;7) in a patient with acute nonlymphocytic leukemia evolved from a myelodysplastic syndrome. / Bernasconi, P.; Cavigliano, P. M.; Genini, E.; Castagnola, C.; Malcovati, L.; Calatroni, S.; Caresana, M.; Boni, M.; Alessandrino, E. P.; Astori, C.; Corso, A.; Bernasconi, C.

In: Cancer Genetics and Cytogenetics, Vol. 105, No. 2, 09.1998, p. 182-186.

Research output: Contribution to journalArticle

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AU - Castagnola, C.

AU - Malcovati, L.

AU - Calatroni, S.

AU - Caresana, M.

AU - Boni, M.

AU - Alessandrino, E. P.

AU - Astori, C.

AU - Corso, A.

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AB - Complete or partial monosomy for the long arms of chromosomes 5 or 7 or both is frequently observed in therapy-related myelodysplostic syndromes and acute nonlymphocytic leukemia. Sporadic cases have been reported in which partial monosomy is due to unbalanced translocations. The patient described herein carries one such rearrangement, 46,XY,t(1;2)(q32;p23),del(5)(q13),der(7)(5qter→ 5q22::7p15→7q21:),del(12)(p12), resulting in partial monosomy for the long arms of chromosomes 5 and 7 and in partial monosomy for the short arm of chromosome 7.

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