A complex translocation (5;7) in a patient with acute nonlymphocytic leukemia evolved from a myelodysplastic syndrome

P. Bernasconi, P. M. Cavigliano, E. Genini, C. Castagnola, L. Malcovati, S. Calatroni, M. Caresana, M. Boni, E. P. Alessandrino, C. Astori, A. Corso, C. Bernasconi

Research output: Contribution to journal › Article

Abstract

Complete or partial monosomy for the long arms of chromosomes 5 or 7 or both is frequently observed in therapy-related myelodysplostic syndromes and acute nonlymphocytic leukemia. Sporadic cases have been reported in which partial monosomy is due to unbalanced translocations. The patient described herein carries one such rearrangement, 46,XY,t(1;2)(q32;p23),del(5)(q13),der(7)(5qter→ 5q22::7p15→7q21:),del(12)(p12), resulting in partial monosomy for the long arms of chromosomes 5 and 7 and in partial monosomy for the short arm of chromosome 7.

Original languageEnglish
Pages (from-to)182-186
Number of pages5
JournalCancer Genetics and Cytogenetics
Volume105
Issue number2
DOIs
Publication statusPublished - Sep 1998

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Chromosome Deletion
Myelodysplastic Syndromes
Acute Myeloid Leukemia
Chromosomes, Human, Pair 7
Chromosomes, Human, Pair 5
Therapeutics

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

A complex translocation (5;7) in a patient with acute nonlymphocytic leukemia evolved from a myelodysplastic syndrome. / Bernasconi, P.; Cavigliano, P. M.; Genini, E.; Castagnola, C.; Malcovati, L.; Calatroni, S.; Caresana, M.; Boni, M.; Alessandrino, E. P.; Astori, C.; Corso, A.; Bernasconi, C.

In: Cancer Genetics and Cytogenetics, Vol. 105, No. 2, 09.1998, p. 182-186.

Research output: Contribution to journal › Article

Bernasconi, P, Cavigliano, PM, Genini, E, Castagnola, C, Malcovati, L, Calatroni, S, Caresana, M, Boni, M, Alessandrino, EP, Astori, C, Corso, A & Bernasconi, C 1998, 'A complex translocation (5;7) in a patient with acute nonlymphocytic leukemia evolved from a myelodysplastic syndrome', Cancer Genetics and Cytogenetics, vol. 105, no. 2, pp. 182-186. https://doi.org/10.1016/S0165-4608(97)00474-3
Bernasconi P, Cavigliano PM, Genini E, Castagnola C, Malcovati L, Calatroni S et al. A complex translocation (5;7) in a patient with acute nonlymphocytic leukemia evolved from a myelodysplastic syndrome. Cancer Genetics and Cytogenetics. 1998 Sep;105(2):182-186. https://doi.org/10.1016/S0165-4608(97)00474-3
Bernasconi, P. ; Cavigliano, P. M. ; Genini, E. ; Castagnola, C. ; Malcovati, L. ; Calatroni, S. ; Caresana, M. ; Boni, M. ; Alessandrino, E. P. ; Astori, C. ; Corso, A. ; Bernasconi, C. / A complex translocation (5;7) in a patient with acute nonlymphocytic leukemia evolved from a myelodysplastic syndrome. In: Cancer Genetics and Cytogenetics. 1998 ; Vol. 105, No. 2. pp. 182-186.
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AU - Malcovati, L.

AU - Calatroni, S.

AU - Caresana, M.

AU - Boni, M.

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AB - Complete or partial monosomy for the long arms of chromosomes 5 or 7 or both is frequently observed in therapy-related myelodysplostic syndromes and acute nonlymphocytic leukemia. Sporadic cases have been reported in which partial monosomy is due to unbalanced translocations. The patient described herein carries one such rearrangement, 46,XY,t(1;2)(q32;p23),del(5)(q13),der(7)(5qter→ 5q22::7p15→7q21:),del(12)(p12), resulting in partial monosomy for the long arms of chromosomes 5 and 7 and in partial monosomy for the short arm of chromosome 7.

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