A composite material model for improved bone formation.

Silvia Scaglione, Erica Lazzarini, Cristina Ilengo, Rodolfo Quarto

Research output: Contribution to journalArticlepeer-review

Abstract

The combination of synthetic polymers and calcium phosphates represent an improvement in the development of scaffolds for bone-tissue regeneration. Ideally, these composites provide both mechanically and architecturally enhanced performances; however, they often lack properties such as osteoconductivity and cell bioactivation. In this study we attempted to generate a composite bone substitute maximizing the available osteoconductive surface for cell adhesion and activity. Highly porous scaffolds were prepared through a particulate leaching method, combining poly-ε-caprolactone (PCL) and hydroxyapatite (HA) particles, previously coated with a sucrose layer, to minimize their embedding by the polymer solution. Composite performances were evaluated both in vitro and in vivo. In PCL-sucrose-coated HA samples, the HA particles were almost completely exposed and physically distinct from the polymer mesh, while uncoated control samples showed ceramic granules massively covered by the polymer. In vivo results revealed a significant extent of bone deposition around all sucrose-coated HA granules, while only parts of the control uncoated HA granules were surrounded by bone matrix. These findings highlight the possibility of generating enhanced osteoconductive materials, basing the scaffold design on physiological and cellular concepts.

Original languageEnglish
Pages (from-to)505-513
Number of pages9
JournalJournal of Tissue Engineering and Regenerative Medicine
Volume4
Issue number7
Publication statusPublished - Oct 2010

ASJC Scopus subject areas

  • Biomedical Engineering
  • Medicine (miscellaneous)
  • Biomaterials

Fingerprint Dive into the research topics of 'A composite material model for improved bone formation.'. Together they form a unique fingerprint.

Cite this