A comprehensive appraisal of meta-analyses focusing on nonsurgical treatments aimed at decreasing perioperative mortality or major cardiac complications

Massimo Zambon, Giuseppe Biondi-Zoccai, Elena Bignami, Laura Ruggeri, Alberto Zangrillo, Giovanni Landoni

Research output: Contribution to journalArticle


Purpose Millions of patients worldwide who undergo surgical procedures face significant morbidity and mortality risks. Several systematic reviews have been performed on ancillary treatments aimed at improving surgical outcomes, but their features and scholarly impact are unclear. We describe characteristics of meta-analyses on ancillary treatments aimed at improving surgical outcomes and explore factors associated with scholarly citations. Methods Systematic reviews published up to 2008 were searched without language restrictions in MEDLINE/Pub- Med. Reviews focusing on nonsurgical treatments aimed at decreasing mortality or major cardiac complications were included. Associations between content, quality, and bibliometric details and scholarly citations in several indexes were systematically appraised. Results From 2,239 citations, 84 systematic reviews were identified. Patients most commonly underwent cardiovascular surgery (40.2 %), and were tested for cardiovascular drugs (25.8 %), with placebo acting as control (38.1 %). Internal validity appeared largely robust, as most (50.5 %) reviews were at low risk of bias. Normalized yearly citations for the included reviews ranged between 5.6 in Google Scholar and 4.3 in Web of Science. Multivariable analysis showed that citations were significantly and positively associated with number of authors, North American corresponding author, number of studies included, number of patients included, noncardiothoracic surgical scope, explicit funding, and lack of competing interests (all P <0.05). Conclusions Systematic reviews currently represent a key element in defining state of the art ancillary treatments of patients undergoing surgery. However, the citation success of available meta-analyses is not significantly associated with prognostically relevant findings or quality features.

Original languageEnglish
Pages (from-to)509-515
Number of pages7
JournalJournal of Anesthesia
Issue number4
Publication statusPublished - Aug 2012



  • Anesthesia
  • Meta-analysis
  • Mortality
  • Myocardial infarction
  • Overview
  • Surgery
  • Systematic review

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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