A computational and experimental study inside microfluidic systems

The role of shear stress and flow recirculation in cell docking

Margherita Cioffi, Matteo Moretti, Amir Manbachi, Bong Geun Chung, Ali Khademhosseini, Gabriele Dubini

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

In this paper, microfluidic devices containing microwells that enabled cell docking were investigated. We theoretically assessed the effect of geometry on recirculation areas and wall shear stress patterns within microwells and studied the relationship between the computational predictions and experimental cell docking. We used microchannels with 150 μm diameter microwells that had either 20 or 80 μm thickness. Flow within 80 μm deep microwells was subject to extensive recirculation areas and low shear stresses (

Original languageEnglish
Pages (from-to)619-626
Number of pages8
JournalBiomedical Microdevices
Volume12
Issue number4
DOIs
Publication statusPublished - Aug 2010

Fingerprint

Microfluidics
Lab-On-A-Chip Devices
Shear flow
Shear stress
Microchannels
Geometry

Keywords

  • Cell docking
  • Computational fluid dynamic
  • Microfluidic device
  • Shear stress

ASJC Scopus subject areas

  • Biomedical Engineering
  • Molecular Biology

Cite this

A computational and experimental study inside microfluidic systems : The role of shear stress and flow recirculation in cell docking. / Cioffi, Margherita; Moretti, Matteo; Manbachi, Amir; Chung, Bong Geun; Khademhosseini, Ali; Dubini, Gabriele.

In: Biomedical Microdevices, Vol. 12, No. 4, 08.2010, p. 619-626.

Research output: Contribution to journalArticle

Cioffi, Margherita ; Moretti, Matteo ; Manbachi, Amir ; Chung, Bong Geun ; Khademhosseini, Ali ; Dubini, Gabriele. / A computational and experimental study inside microfluidic systems : The role of shear stress and flow recirculation in cell docking. In: Biomedical Microdevices. 2010 ; Vol. 12, No. 4. pp. 619-626.
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