A computational and experimental study inside microfluidic systems: The role of shear stress and flow recirculation in cell docking

Margherita Cioffi, Matteo Moretti, Amir Manbachi, Bong Geun Chung, Ali Khademhosseini, Gabriele Dubini

Research output: Contribution to journalArticle

Abstract

In this paper, microfluidic devices containing microwells that enabled cell docking were investigated. We theoretically assessed the effect of geometry on recirculation areas and wall shear stress patterns within microwells and studied the relationship between the computational predictions and experimental cell docking. We used microchannels with 150 μm diameter microwells that had either 20 or 80 μm thickness. Flow within 80 μm deep microwells was subject to extensive recirculation areas and low shear stresses (

Original languageEnglish
Pages (from-to)619-626
Number of pages8
JournalBiomedical Microdevices
Volume12
Issue number4
DOIs
Publication statusPublished - Aug 2010

Keywords

  • Cell docking
  • Computational fluid dynamic
  • Microfluidic device
  • Shear stress

ASJC Scopus subject areas

  • Biomedical Engineering
  • Molecular Biology

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