TY - JOUR
T1 - A Computational Fluid-Structure Interaction Study for Carotids with Different Atherosclerotic Plaques
AU - Bennati, Lorenzo
AU - Vergara, Christian
AU - Domanin, Maurizio
AU - Malloggi, Chiara
AU - Bissacco, Daniele
AU - Trimarchi, Santi
AU - Silani, Vincenzo
AU - Parati, Gianfranco
AU - Casana, Renato
N1 - Publisher Copyright:
© 2021 American Society of Civil Engineers (ASCE). All rights reserved.
PY - 2021/9/1
Y1 - 2021/9/1
N2 - Atherosclerosis is a systemic disease that leads to accumulation of deposits, known as atherosclerotic plaques, within the walls of the carotids. In particular, three types of plaque can be distinguished: soft, fibrous, and calcific. Most of the computational studies who investigated the interplay between the plaque and the blood flow on patient-specific geometries used nonstandard medical images to directly delineate and segment the plaque and its components. However, these techniques are not so widely available in the clinical practice. In this context, the aim of our work was twofold: (i) to propose a new geometric tool that allowed to reconstruct a plausible plaque in the carotids from standard images and (ii) to perform three-dimensional (3D) fluid-structure interaction (FSI) simulations where we compared some fluid-dynamic and structural quantities among 15 patients characterized by different typologies of plaque. Our results highlighted that both the morphology and the mechanical properties of different plaque components play a crucial role in determining the vulnerability of the plaque.
AB - Atherosclerosis is a systemic disease that leads to accumulation of deposits, known as atherosclerotic plaques, within the walls of the carotids. In particular, three types of plaque can be distinguished: soft, fibrous, and calcific. Most of the computational studies who investigated the interplay between the plaque and the blood flow on patient-specific geometries used nonstandard medical images to directly delineate and segment the plaque and its components. However, these techniques are not so widely available in the clinical practice. In this context, the aim of our work was twofold: (i) to propose a new geometric tool that allowed to reconstruct a plausible plaque in the carotids from standard images and (ii) to perform three-dimensional (3D) fluid-structure interaction (FSI) simulations where we compared some fluid-dynamic and structural quantities among 15 patients characterized by different typologies of plaque. Our results highlighted that both the morphology and the mechanical properties of different plaque components play a crucial role in determining the vulnerability of the plaque.
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U2 - 10.1115/1.4050910
DO - 10.1115/1.4050910
M3 - Article
C2 - 33876184
AN - SCOPUS:85105711729
VL - 143
JO - Journal of Biomechanical Engineering
JF - Journal of Biomechanical Engineering
SN - 0148-0731
IS - 9
M1 - 1107993
ER -