A computer-aided diagnosis system for the assessment and characterization of low-to-high suspicion thyroid nodules on ultrasound

Salvatore Gitto, Giorgia Grassi, Chiara De Angelis, Cristian Giuseppe Monaco, Silvana Sdao, Francesco Sardanelli, Luca Maria Sconfienza, Giovanni Mauri

Research output: Contribution to journalArticle

Abstract

AIM OF THE STUDY: To compare the diagnostic performance of a commercially available computer-aided diagnosis (CAD) system for thyroid ultrasound (US) with that of a non-computer-aided radiologist in the characterization of low-to-high suspicion thyroid nodules.

METHODS: This retrospective study included a consecutive series of adult patients referred for US-guided fine-needle aspiration biopsy (FNAB) of a thyroid nodule. All patients were eligible for thyroid nodule FNAB according to the current international guidelines. An interventional radiologist experienced in thyroid imaging acquired the US images subsequently used for post-processing, performed FNAB and provided the US features of each nodule. A radiology resident and an endocrinology resident in consensus performed post-processing using the CAD system to assess the same nodule characteristics. The diagnostic performance and agreement of US features between the CAD system and the radiologist were compared.

RESULTS: Sixty-two patients (50 F; age 60 ± 12 years) were enrolled: 77.4% (48/62) of thyroid nodules were benign, 22.6% (14/62) were undetermined to malignant and required follow-up or surgery. Interobserver agreement between the CAD system and the radiologist was substantial for orientation (K = 0.69), fair for composition (K = 0.36), echogenicity (K = 0.36), K-TIRADS (K = 0.29), and slight for margins (K = 0.03). The radiologist demonstrated a significantly higher sensitivity than the CAD system (78.6% vs. 21.4%; P = 0.008), while there was no statistical difference in specificity (66.7% vs. 81.3%; P = 0.065).

CONCLUSION: This CAD system is less sensitive than an experienced radiologist and showed slight-to-substantial agreement with the radiologist for the characterization of thyroid nodules. Although it is an innovative tool with good potential, additional efforts are needed to improve its diagnostic performance.

Original languageEnglish
Pages (from-to)118-125
Number of pages8
JournalRadiol. Med.
Volume124
Issue number2
DOIs
Publication statusPublished - Feb 2019

Keywords

  • Diagnosis, Computer-Assisted
  • Diagnosis, Differential
  • Female
  • Humans
  • Image-Guided Biopsy
  • Male
  • Middle Aged
  • Retrospective Studies
  • Sensitivity and Specificity
  • Thyroid Neoplasms
  • Thyroid Nodule/diagnostic imaging
  • Ultrasonography/methods

Fingerprint Dive into the research topics of 'A computer-aided diagnosis system for the assessment and characterization of low-to-high suspicion thyroid nodules on ultrasound'. Together they form a unique fingerprint.

  • Cite this