A consensus protocol for the management of medication-overuse headache: Evaluation in a multicentric, multinational study

C. Tassorelli, R. Jensen, M. Allena, R. De Icco, G. Sances, Z. Katsarava, M. Lainez, J. A. Leston, R. Fadic, S. Spadafora, M. Pagani, G. Nappi

Research output: Contribution to journalArticle

Abstract

Introduction: The management of medication-overuse headache (MOH) is often difficult and no specific guidelines are available as regards the most practical and effective approaches. In this study we defined and tested a consensus protocol for the management of MOH on a large population of patients distributed in different countries. Subjects and methods: The protocol was based on evidence from the literature and on consolidated expertise of the members of the consensus group. The study was conducted according to a multicentric interventional design with the enrolment of 376 MOH subjects in four centres from Europe and two centres in Latin America. The majority of patients were treated according to an outpatient detoxification programme. The post-detoxification follow-up lasted six months. Results: At the final evaluation, two-thirds of the subjects were no longer overusers and in 46.5% of subjects headache had reverted back to an episodic pattern of headache. When comparing the subjects who underwent out-patient detoxification vs those treated with in-patient detoxification, both regimens proved effective, although the drop-out rate was higher in the out-patient approach. Conclusions: The present findings support the effectiveness and usability of the proposed consensus protocol in different countries with different health care modalities.

Original languageEnglish
Pages (from-to)645-655
Number of pages11
JournalCephalalgia
Volume34
Issue number9
DOIs
Publication statusPublished - 2014

Fingerprint

Secondary Headache Disorders
Outpatients
Headache
Latin America
Guidelines
Delivery of Health Care
Population

Keywords

  • analgesics
  • chronic headache
  • consensus protocol
  • detoxification
  • Medication-overuse headache
  • migraine

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

A consensus protocol for the management of medication-overuse headache : Evaluation in a multicentric, multinational study. / Tassorelli, C.; Jensen, R.; Allena, M.; De Icco, R.; Sances, G.; Katsarava, Z.; Lainez, M.; Leston, J. A.; Fadic, R.; Spadafora, S.; Pagani, M.; Nappi, G.

In: Cephalalgia, Vol. 34, No. 9, 2014, p. 645-655.

Research output: Contribution to journalArticle

Tassorelli, C, Jensen, R, Allena, M, De Icco, R, Sances, G, Katsarava, Z, Lainez, M, Leston, JA, Fadic, R, Spadafora, S, Pagani, M & Nappi, G 2014, 'A consensus protocol for the management of medication-overuse headache: Evaluation in a multicentric, multinational study', Cephalalgia, vol. 34, no. 9, pp. 645-655. https://doi.org/10.1177/0333102414521508
Tassorelli, C. ; Jensen, R. ; Allena, M. ; De Icco, R. ; Sances, G. ; Katsarava, Z. ; Lainez, M. ; Leston, J. A. ; Fadic, R. ; Spadafora, S. ; Pagani, M. ; Nappi, G. / A consensus protocol for the management of medication-overuse headache : Evaluation in a multicentric, multinational study. In: Cephalalgia. 2014 ; Vol. 34, No. 9. pp. 645-655.
@article{bc035e1d07194cb6af4ef341106e23c4,
title = "A consensus protocol for the management of medication-overuse headache: Evaluation in a multicentric, multinational study",
abstract = "Introduction: The management of medication-overuse headache (MOH) is often difficult and no specific guidelines are available as regards the most practical and effective approaches. In this study we defined and tested a consensus protocol for the management of MOH on a large population of patients distributed in different countries. Subjects and methods: The protocol was based on evidence from the literature and on consolidated expertise of the members of the consensus group. The study was conducted according to a multicentric interventional design with the enrolment of 376 MOH subjects in four centres from Europe and two centres in Latin America. The majority of patients were treated according to an outpatient detoxification programme. The post-detoxification follow-up lasted six months. Results: At the final evaluation, two-thirds of the subjects were no longer overusers and in 46.5{\%} of subjects headache had reverted back to an episodic pattern of headache. When comparing the subjects who underwent out-patient detoxification vs those treated with in-patient detoxification, both regimens proved effective, although the drop-out rate was higher in the out-patient approach. Conclusions: The present findings support the effectiveness and usability of the proposed consensus protocol in different countries with different health care modalities.",
keywords = "analgesics, chronic headache, consensus protocol, detoxification, Medication-overuse headache, migraine",
author = "C. Tassorelli and R. Jensen and M. Allena and {De Icco}, R. and G. Sances and Z. Katsarava and M. Lainez and Leston, {J. A.} and R. Fadic and S. Spadafora and M. Pagani and G. Nappi",
year = "2014",
doi = "10.1177/0333102414521508",
language = "English",
volume = "34",
pages = "645--655",
journal = "Cephalalgia",
issn = "0333-1024",
publisher = "SAGE Publications Ltd",
number = "9",

}

TY - JOUR

T1 - A consensus protocol for the management of medication-overuse headache

T2 - Evaluation in a multicentric, multinational study

AU - Tassorelli, C.

AU - Jensen, R.

AU - Allena, M.

AU - De Icco, R.

AU - Sances, G.

AU - Katsarava, Z.

AU - Lainez, M.

AU - Leston, J. A.

AU - Fadic, R.

AU - Spadafora, S.

AU - Pagani, M.

AU - Nappi, G.

PY - 2014

Y1 - 2014

N2 - Introduction: The management of medication-overuse headache (MOH) is often difficult and no specific guidelines are available as regards the most practical and effective approaches. In this study we defined and tested a consensus protocol for the management of MOH on a large population of patients distributed in different countries. Subjects and methods: The protocol was based on evidence from the literature and on consolidated expertise of the members of the consensus group. The study was conducted according to a multicentric interventional design with the enrolment of 376 MOH subjects in four centres from Europe and two centres in Latin America. The majority of patients were treated according to an outpatient detoxification programme. The post-detoxification follow-up lasted six months. Results: At the final evaluation, two-thirds of the subjects were no longer overusers and in 46.5% of subjects headache had reverted back to an episodic pattern of headache. When comparing the subjects who underwent out-patient detoxification vs those treated with in-patient detoxification, both regimens proved effective, although the drop-out rate was higher in the out-patient approach. Conclusions: The present findings support the effectiveness and usability of the proposed consensus protocol in different countries with different health care modalities.

AB - Introduction: The management of medication-overuse headache (MOH) is often difficult and no specific guidelines are available as regards the most practical and effective approaches. In this study we defined and tested a consensus protocol for the management of MOH on a large population of patients distributed in different countries. Subjects and methods: The protocol was based on evidence from the literature and on consolidated expertise of the members of the consensus group. The study was conducted according to a multicentric interventional design with the enrolment of 376 MOH subjects in four centres from Europe and two centres in Latin America. The majority of patients were treated according to an outpatient detoxification programme. The post-detoxification follow-up lasted six months. Results: At the final evaluation, two-thirds of the subjects were no longer overusers and in 46.5% of subjects headache had reverted back to an episodic pattern of headache. When comparing the subjects who underwent out-patient detoxification vs those treated with in-patient detoxification, both regimens proved effective, although the drop-out rate was higher in the out-patient approach. Conclusions: The present findings support the effectiveness and usability of the proposed consensus protocol in different countries with different health care modalities.

KW - analgesics

KW - chronic headache

KW - consensus protocol

KW - detoxification

KW - Medication-overuse headache

KW - migraine

UR - http://www.scopus.com/inward/record.url?scp=84903272627&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84903272627&partnerID=8YFLogxK

U2 - 10.1177/0333102414521508

DO - 10.1177/0333102414521508

M3 - Article

AN - SCOPUS:84903272627

VL - 34

SP - 645

EP - 655

JO - Cephalalgia

JF - Cephalalgia

SN - 0333-1024

IS - 9

ER -