A contemporary analysis of radiotherapy effect in surgically treated retroperitoneal sarcoma

Sebastiano Nazzani, Marco Bandini, Michele Marchioni, Felix Preisser, Zhe Tian, Denis Soulières, Emanuele Montanari, Gloria Motta, Pietro Acquati, Alberto Briganti, Shahrokh F. Shariat, Firas Abdollah, Luca Carmignani, Pierre I. Karakiewicz

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background and purpose: Contemporary data regarding the benefit of radiotherapy in surgically treated retroperitoneal sarcoma are scarce. The aim of the study was to evaluate the effect of radiotherapy on cancer specific mortality in surgically treated patients according to tumor size, histological subtype and grade. Material and methods: Within Surveillance, Epidemiology, and End Results database (2004–2014), we identified 1226 patients with non-metastatic retroperitoneal sarcoma. Univariable and multivariable logistic regression models tested for predictors of radiotherapy delivery. Univariable and multivariable Cox regression models tested the effect of radiotherapy on cancer specific mortality in the overall population. Subgroup analyses explored the result of tumor grade and tumor size on radiotherapy effect. All analyses were repeated after adjustment according to inverse probability of treatment. Additionally, all analyses were subjected to 1000 bootstrap resamples for internal validation. Results: Radiotherapy was delivered in 372 patients (30.3%). In univariable and multivariable logistic regression models high grade (OR: 1.46, CI:1.12–1.90; p = 0.006), and leiomyosarcoma histologic subtype (OR: 2.14, CI: 1.55–2.95; p < 0.001) predicted radiotherapy delivery. In the overall population multivariable Cox regression models showed lower cancer specific mortality (HR: 0.73, CI: 0.55–0.96; p = 0.025) with radiotherapy. In subgroup analyses multivariable Cox regression models showed radiotherapy benefit predominantly in high grade, large tumor size retroperitoneal sarcomas (HR 0.51: C.I.: 0.30–0.86; p = 0.02). Conclusions: In this retrospective report, delivery of radiotherapy was associated with lower cancer specific mortality in high grade, large tumor size retroperitoneal sarcoma patients. Our findings are predominantly representative of liposarcomas and leiomyosarcomas that accounted for 90% of study population. Further study is needed to evaluate the role of radiotherapy in retroperitoneal sarcoma patients.

Original languageEnglish
Pages (from-to)318-325
Number of pages8
JournalRadiotherapy and Oncology
Volume127
Issue number2
DOIs
Publication statusPublished - May 1 2018

Fingerprint

Sarcoma
Radiotherapy
Neoplasms
Logistic Models
Proportional Hazards Models
Leiomyosarcoma
Mortality
Population
Liposarcoma
Epidemiology
Databases

Keywords

  • Radiotherapy
  • Retroperitoneum
  • Sarcoma

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Radiology Nuclear Medicine and imaging

Cite this

Nazzani, S., Bandini, M., Marchioni, M., Preisser, F., Tian, Z., Soulières, D., ... Karakiewicz, P. I. (2018). A contemporary analysis of radiotherapy effect in surgically treated retroperitoneal sarcoma. Radiotherapy and Oncology, 127(2), 318-325. https://doi.org/10.1016/j.radonc.2018.03.027

A contemporary analysis of radiotherapy effect in surgically treated retroperitoneal sarcoma. / Nazzani, Sebastiano; Bandini, Marco; Marchioni, Michele; Preisser, Felix; Tian, Zhe; Soulières, Denis; Montanari, Emanuele; Motta, Gloria; Acquati, Pietro; Briganti, Alberto; Shariat, Shahrokh F.; Abdollah, Firas; Carmignani, Luca; Karakiewicz, Pierre I.

In: Radiotherapy and Oncology, Vol. 127, No. 2, 01.05.2018, p. 318-325.

Research output: Contribution to journalArticle

Nazzani, S, Bandini, M, Marchioni, M, Preisser, F, Tian, Z, Soulières, D, Montanari, E, Motta, G, Acquati, P, Briganti, A, Shariat, SF, Abdollah, F, Carmignani, L & Karakiewicz, PI 2018, 'A contemporary analysis of radiotherapy effect in surgically treated retroperitoneal sarcoma', Radiotherapy and Oncology, vol. 127, no. 2, pp. 318-325. https://doi.org/10.1016/j.radonc.2018.03.027
Nazzani, Sebastiano ; Bandini, Marco ; Marchioni, Michele ; Preisser, Felix ; Tian, Zhe ; Soulières, Denis ; Montanari, Emanuele ; Motta, Gloria ; Acquati, Pietro ; Briganti, Alberto ; Shariat, Shahrokh F. ; Abdollah, Firas ; Carmignani, Luca ; Karakiewicz, Pierre I. / A contemporary analysis of radiotherapy effect in surgically treated retroperitoneal sarcoma. In: Radiotherapy and Oncology. 2018 ; Vol. 127, No. 2. pp. 318-325.
@article{2f7d86646e47457bbf27015a624ef47b,
title = "A contemporary analysis of radiotherapy effect in surgically treated retroperitoneal sarcoma",
abstract = "Background and purpose: Contemporary data regarding the benefit of radiotherapy in surgically treated retroperitoneal sarcoma are scarce. The aim of the study was to evaluate the effect of radiotherapy on cancer specific mortality in surgically treated patients according to tumor size, histological subtype and grade. Material and methods: Within Surveillance, Epidemiology, and End Results database (2004–2014), we identified 1226 patients with non-metastatic retroperitoneal sarcoma. Univariable and multivariable logistic regression models tested for predictors of radiotherapy delivery. Univariable and multivariable Cox regression models tested the effect of radiotherapy on cancer specific mortality in the overall population. Subgroup analyses explored the result of tumor grade and tumor size on radiotherapy effect. All analyses were repeated after adjustment according to inverse probability of treatment. Additionally, all analyses were subjected to 1000 bootstrap resamples for internal validation. Results: Radiotherapy was delivered in 372 patients (30.3{\%}). In univariable and multivariable logistic regression models high grade (OR: 1.46, CI:1.12–1.90; p = 0.006), and leiomyosarcoma histologic subtype (OR: 2.14, CI: 1.55–2.95; p < 0.001) predicted radiotherapy delivery. In the overall population multivariable Cox regression models showed lower cancer specific mortality (HR: 0.73, CI: 0.55–0.96; p = 0.025) with radiotherapy. In subgroup analyses multivariable Cox regression models showed radiotherapy benefit predominantly in high grade, large tumor size retroperitoneal sarcomas (HR 0.51: C.I.: 0.30–0.86; p = 0.02). Conclusions: In this retrospective report, delivery of radiotherapy was associated with lower cancer specific mortality in high grade, large tumor size retroperitoneal sarcoma patients. Our findings are predominantly representative of liposarcomas and leiomyosarcomas that accounted for 90{\%} of study population. Further study is needed to evaluate the role of radiotherapy in retroperitoneal sarcoma patients.",
keywords = "Radiotherapy, Retroperitoneum, Sarcoma",
author = "Sebastiano Nazzani and Marco Bandini and Michele Marchioni and Felix Preisser and Zhe Tian and Denis Souli{\`e}res and Emanuele Montanari and Gloria Motta and Pietro Acquati and Alberto Briganti and Shariat, {Shahrokh F.} and Firas Abdollah and Luca Carmignani and Karakiewicz, {Pierre I.}",
year = "2018",
month = "5",
day = "1",
doi = "10.1016/j.radonc.2018.03.027",
language = "English",
volume = "127",
pages = "318--325",
journal = "Radiotherapy and Oncology",
issn = "0167-8140",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - A contemporary analysis of radiotherapy effect in surgically treated retroperitoneal sarcoma

AU - Nazzani, Sebastiano

AU - Bandini, Marco

AU - Marchioni, Michele

AU - Preisser, Felix

AU - Tian, Zhe

AU - Soulières, Denis

AU - Montanari, Emanuele

AU - Motta, Gloria

AU - Acquati, Pietro

AU - Briganti, Alberto

AU - Shariat, Shahrokh F.

AU - Abdollah, Firas

AU - Carmignani, Luca

AU - Karakiewicz, Pierre I.

PY - 2018/5/1

Y1 - 2018/5/1

N2 - Background and purpose: Contemporary data regarding the benefit of radiotherapy in surgically treated retroperitoneal sarcoma are scarce. The aim of the study was to evaluate the effect of radiotherapy on cancer specific mortality in surgically treated patients according to tumor size, histological subtype and grade. Material and methods: Within Surveillance, Epidemiology, and End Results database (2004–2014), we identified 1226 patients with non-metastatic retroperitoneal sarcoma. Univariable and multivariable logistic regression models tested for predictors of radiotherapy delivery. Univariable and multivariable Cox regression models tested the effect of radiotherapy on cancer specific mortality in the overall population. Subgroup analyses explored the result of tumor grade and tumor size on radiotherapy effect. All analyses were repeated after adjustment according to inverse probability of treatment. Additionally, all analyses were subjected to 1000 bootstrap resamples for internal validation. Results: Radiotherapy was delivered in 372 patients (30.3%). In univariable and multivariable logistic regression models high grade (OR: 1.46, CI:1.12–1.90; p = 0.006), and leiomyosarcoma histologic subtype (OR: 2.14, CI: 1.55–2.95; p < 0.001) predicted radiotherapy delivery. In the overall population multivariable Cox regression models showed lower cancer specific mortality (HR: 0.73, CI: 0.55–0.96; p = 0.025) with radiotherapy. In subgroup analyses multivariable Cox regression models showed radiotherapy benefit predominantly in high grade, large tumor size retroperitoneal sarcomas (HR 0.51: C.I.: 0.30–0.86; p = 0.02). Conclusions: In this retrospective report, delivery of radiotherapy was associated with lower cancer specific mortality in high grade, large tumor size retroperitoneal sarcoma patients. Our findings are predominantly representative of liposarcomas and leiomyosarcomas that accounted for 90% of study population. Further study is needed to evaluate the role of radiotherapy in retroperitoneal sarcoma patients.

AB - Background and purpose: Contemporary data regarding the benefit of radiotherapy in surgically treated retroperitoneal sarcoma are scarce. The aim of the study was to evaluate the effect of radiotherapy on cancer specific mortality in surgically treated patients according to tumor size, histological subtype and grade. Material and methods: Within Surveillance, Epidemiology, and End Results database (2004–2014), we identified 1226 patients with non-metastatic retroperitoneal sarcoma. Univariable and multivariable logistic regression models tested for predictors of radiotherapy delivery. Univariable and multivariable Cox regression models tested the effect of radiotherapy on cancer specific mortality in the overall population. Subgroup analyses explored the result of tumor grade and tumor size on radiotherapy effect. All analyses were repeated after adjustment according to inverse probability of treatment. Additionally, all analyses were subjected to 1000 bootstrap resamples for internal validation. Results: Radiotherapy was delivered in 372 patients (30.3%). In univariable and multivariable logistic regression models high grade (OR: 1.46, CI:1.12–1.90; p = 0.006), and leiomyosarcoma histologic subtype (OR: 2.14, CI: 1.55–2.95; p < 0.001) predicted radiotherapy delivery. In the overall population multivariable Cox regression models showed lower cancer specific mortality (HR: 0.73, CI: 0.55–0.96; p = 0.025) with radiotherapy. In subgroup analyses multivariable Cox regression models showed radiotherapy benefit predominantly in high grade, large tumor size retroperitoneal sarcomas (HR 0.51: C.I.: 0.30–0.86; p = 0.02). Conclusions: In this retrospective report, delivery of radiotherapy was associated with lower cancer specific mortality in high grade, large tumor size retroperitoneal sarcoma patients. Our findings are predominantly representative of liposarcomas and leiomyosarcomas that accounted for 90% of study population. Further study is needed to evaluate the role of radiotherapy in retroperitoneal sarcoma patients.

KW - Radiotherapy

KW - Retroperitoneum

KW - Sarcoma

UR - http://www.scopus.com/inward/record.url?scp=85047647545&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85047647545&partnerID=8YFLogxK

U2 - 10.1016/j.radonc.2018.03.027

DO - 10.1016/j.radonc.2018.03.027

M3 - Article

AN - SCOPUS:85047647545

VL - 127

SP - 318

EP - 325

JO - Radiotherapy and Oncology

JF - Radiotherapy and Oncology

SN - 0167-8140

IS - 2

ER -